Acinetobacter baumannii among Patients Receiving Glucocorticoid Aerosol Therapy during Invasive Mechanical Ventilation, China
Acinetobacter baumannii is a nosocomial pathogen associated with severe illness and death. Glucocorticoid aerosol is a common inhalation therapy in patients receiving invasive mechanical ventilation. We conducted a prospective cohort study to analyze the association between glucocorticoid aerosol t...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
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Centers for Disease Control and Prevention
2022-12-01
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Series: | Emerging Infectious Diseases |
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Online Access: | https://wwwnc.cdc.gov/eid/article/28/12/22-0347_article |
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author | Wenchao Zhang Mei Yin Wei Li Nana Xu Haining Lu Weidong Qin Hui Han Chen Li Dawei Wu Hao Wang |
author_facet | Wenchao Zhang Mei Yin Wei Li Nana Xu Haining Lu Weidong Qin Hui Han Chen Li Dawei Wu Hao Wang |
author_sort | Wenchao Zhang |
collection | DOAJ |
description |
Acinetobacter baumannii is a nosocomial pathogen associated with severe illness and death. Glucocorticoid aerosol is a common inhalation therapy in patients receiving invasive mechanical ventilation. We conducted a prospective cohort study to analyze the association between glucocorticoid aerosol therapy and A. baumannii isolation from ventilator patients in China. Of 497 enrolled patients, 262 (52.7%) received glucocorticoid aerosol, and A. baumannii was isolated from 159 (32.0%). Glucocorticoid aerosol therapy was an independent risk factor for A. baumannii isolation (hazard ratio 1.5, 95% CI 1.02–2.28; p = 0.038). Patients receiving glucocorticoid aerosol had a higher cumulative hazard for A. baumannii isolation and analysis showed that glucocorticoid aerosol therapy increased A. baumannii isolation in most subpopulations. Glucocorticoid aerosol was not a direct risk factor for 30-day mortality, but A. baumannii isolation was independently associated with 30-day mortality in ventilator patients. Physicians should consider potential A. baumannii infection when prescribing glucocorticoid aerosol therapy.
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first_indexed | 2024-04-11T06:34:21Z |
format | Article |
id | doaj.art-eca7fdc7c1834338819ac0bdf2a46df3 |
institution | Directory Open Access Journal |
issn | 1080-6040 1080-6059 |
language | English |
last_indexed | 2024-04-11T06:34:21Z |
publishDate | 2022-12-01 |
publisher | Centers for Disease Control and Prevention |
record_format | Article |
series | Emerging Infectious Diseases |
spelling | doaj.art-eca7fdc7c1834338819ac0bdf2a46df32022-12-22T04:39:52ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592022-12-0128122404240410.3201/eid2812.220347Acinetobacter baumannii among Patients Receiving Glucocorticoid Aerosol Therapy during Invasive Mechanical Ventilation, ChinaWenchao ZhangMei YinWei LiNana XuHaining LuWeidong QinHui HanChen LiDawei WuHao Wang Acinetobacter baumannii is a nosocomial pathogen associated with severe illness and death. Glucocorticoid aerosol is a common inhalation therapy in patients receiving invasive mechanical ventilation. We conducted a prospective cohort study to analyze the association between glucocorticoid aerosol therapy and A. baumannii isolation from ventilator patients in China. Of 497 enrolled patients, 262 (52.7%) received glucocorticoid aerosol, and A. baumannii was isolated from 159 (32.0%). Glucocorticoid aerosol therapy was an independent risk factor for A. baumannii isolation (hazard ratio 1.5, 95% CI 1.02–2.28; p = 0.038). Patients receiving glucocorticoid aerosol had a higher cumulative hazard for A. baumannii isolation and analysis showed that glucocorticoid aerosol therapy increased A. baumannii isolation in most subpopulations. Glucocorticoid aerosol was not a direct risk factor for 30-day mortality, but A. baumannii isolation was independently associated with 30-day mortality in ventilator patients. Physicians should consider potential A. baumannii infection when prescribing glucocorticoid aerosol therapy. https://wwwnc.cdc.gov/eid/article/28/12/22-0347_articleAcinetobacter baumanniibacteriaantimicrobial resistanceaerosol inhalationglucocorticoidinvasive mechanical ventilation |
spellingShingle | Wenchao Zhang Mei Yin Wei Li Nana Xu Haining Lu Weidong Qin Hui Han Chen Li Dawei Wu Hao Wang Acinetobacter baumannii among Patients Receiving Glucocorticoid Aerosol Therapy during Invasive Mechanical Ventilation, China Emerging Infectious Diseases Acinetobacter baumannii bacteria antimicrobial resistance aerosol inhalation glucocorticoid invasive mechanical ventilation |
title | Acinetobacter baumannii among Patients Receiving Glucocorticoid Aerosol Therapy during Invasive Mechanical Ventilation, China |
title_full | Acinetobacter baumannii among Patients Receiving Glucocorticoid Aerosol Therapy during Invasive Mechanical Ventilation, China |
title_fullStr | Acinetobacter baumannii among Patients Receiving Glucocorticoid Aerosol Therapy during Invasive Mechanical Ventilation, China |
title_full_unstemmed | Acinetobacter baumannii among Patients Receiving Glucocorticoid Aerosol Therapy during Invasive Mechanical Ventilation, China |
title_short | Acinetobacter baumannii among Patients Receiving Glucocorticoid Aerosol Therapy during Invasive Mechanical Ventilation, China |
title_sort | acinetobacter baumannii among patients receiving glucocorticoid aerosol therapy during invasive mechanical ventilation china |
topic | Acinetobacter baumannii bacteria antimicrobial resistance aerosol inhalation glucocorticoid invasive mechanical ventilation |
url | https://wwwnc.cdc.gov/eid/article/28/12/22-0347_article |
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