Corilagin Represses Epithelial to Mesenchymal Transition Process Through Modulating Wnt/β-Catenin Signaling Cascade
Corilagin (CLG), a major component of several medicinal plants, can exhibit diverse pharmacological properties including those of anti-cancer, anti-inflammatory, and hepatoprotective qualities. However, there are no prior studies on its potential impact on the epithelial-to-mesenchymal transition (E...
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| Format: | Article |
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MDPI AG
2020-10-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/10/1406 |
| _version_ | 1797551805179101184 |
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| author | Sun Tae Hwang Min Hee Yang Alan Prem Kumar Gautam Sethi Kwang Seok Ahn |
| author_facet | Sun Tae Hwang Min Hee Yang Alan Prem Kumar Gautam Sethi Kwang Seok Ahn |
| author_sort | Sun Tae Hwang |
| collection | DOAJ |
| description | Corilagin (CLG), a major component of several medicinal plants, can exhibit diverse pharmacological properties including those of anti-cancer, anti-inflammatory, and hepatoprotective qualities. However, there are no prior studies on its potential impact on the epithelial-to-mesenchymal transition (EMT) process. EMT can lead to dissemination of tumor cells into other organs and promote cancer progression. Hence, we aimed to investigate the effect of CLG on EMT and its mechanism(s) of action in tumor cells. We noted that CLG reduced the expression of various epithelial markers and up-regulated the expression of Occludin and E-cadherin in both basal and TGFβ-stimulated tumor cells. CLG treatment also abrogated cellular invasion and migration in colon and prostate carcinoma cells. In addition, CLG effectively attenuated the Wnt/β-catenin signaling cascade in TGFβ-stimulated cells. Overall, our study suggests that CLG may function as and effective modulator of EMT and metastasis in neoplastic cells. |
| first_indexed | 2024-03-10T15:50:16Z |
| format | Article |
| id | doaj.art-ecab185416504011bdc9a827277806b8 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T15:50:16Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-ecab185416504011bdc9a827277806b82023-11-20T16:07:15ZengMDPI AGBiomolecules2218-273X2020-10-011010140610.3390/biom10101406Corilagin Represses Epithelial to Mesenchymal Transition Process Through Modulating Wnt/β-Catenin Signaling CascadeSun Tae Hwang0Min Hee Yang1Alan Prem Kumar2Gautam Sethi3Kwang Seok Ahn4Department of Science in Korean Medicine, Kyung Hee University, Seoul 02447, KoreaDepartment of Science in Korean Medicine, Kyung Hee University, Seoul 02447, KoreaDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeDepartment of Science in Korean Medicine, Kyung Hee University, Seoul 02447, KoreaCorilagin (CLG), a major component of several medicinal plants, can exhibit diverse pharmacological properties including those of anti-cancer, anti-inflammatory, and hepatoprotective qualities. However, there are no prior studies on its potential impact on the epithelial-to-mesenchymal transition (EMT) process. EMT can lead to dissemination of tumor cells into other organs and promote cancer progression. Hence, we aimed to investigate the effect of CLG on EMT and its mechanism(s) of action in tumor cells. We noted that CLG reduced the expression of various epithelial markers and up-regulated the expression of Occludin and E-cadherin in both basal and TGFβ-stimulated tumor cells. CLG treatment also abrogated cellular invasion and migration in colon and prostate carcinoma cells. In addition, CLG effectively attenuated the Wnt/β-catenin signaling cascade in TGFβ-stimulated cells. Overall, our study suggests that CLG may function as and effective modulator of EMT and metastasis in neoplastic cells.https://www.mdpi.com/2218-273X/10/10/1406corilaginepithelial-to-mesenchymal transitionWnt/β-catenininvasionmigration |
| spellingShingle | Sun Tae Hwang Min Hee Yang Alan Prem Kumar Gautam Sethi Kwang Seok Ahn Corilagin Represses Epithelial to Mesenchymal Transition Process Through Modulating Wnt/β-Catenin Signaling Cascade Biomolecules corilagin epithelial-to-mesenchymal transition Wnt/β-catenin invasion migration |
| title | Corilagin Represses Epithelial to Mesenchymal Transition Process Through Modulating Wnt/β-Catenin Signaling Cascade |
| title_full | Corilagin Represses Epithelial to Mesenchymal Transition Process Through Modulating Wnt/β-Catenin Signaling Cascade |
| title_fullStr | Corilagin Represses Epithelial to Mesenchymal Transition Process Through Modulating Wnt/β-Catenin Signaling Cascade |
| title_full_unstemmed | Corilagin Represses Epithelial to Mesenchymal Transition Process Through Modulating Wnt/β-Catenin Signaling Cascade |
| title_short | Corilagin Represses Epithelial to Mesenchymal Transition Process Through Modulating Wnt/β-Catenin Signaling Cascade |
| title_sort | corilagin represses epithelial to mesenchymal transition process through modulating wnt β catenin signaling cascade |
| topic | corilagin epithelial-to-mesenchymal transition Wnt/β-catenin invasion migration |
| url | https://www.mdpi.com/2218-273X/10/10/1406 |
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