MicroRNA regulation and tissue-specific protein interaction network.
BACKGROUND: 'Fine-tuning' of protein abundance makes microRNAs (miRNAs) pervasively implicated in human biology. Although targeting many mRNAs endows the power of single miRNA to regulate complex biological processes, its functional roles in a particular tissue will be inevitably restricte...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3181334?pdf=render |
| _version_ | 1819276527222652928 |
|---|---|
| author | Wenliang Zhu Lei Yang Zhimin Du |
| author_facet | Wenliang Zhu Lei Yang Zhimin Du |
| author_sort | Wenliang Zhu |
| collection | DOAJ |
| description | BACKGROUND: 'Fine-tuning' of protein abundance makes microRNAs (miRNAs) pervasively implicated in human biology. Although targeting many mRNAs endows the power of single miRNA to regulate complex biological processes, its functional roles in a particular tissue will be inevitably restricted because only a subset of its target genes is expressed. METHODS: Here, we analyze the characteristics of miRNA regulation upon target genes according to tissue-specific gene expression by constructing tissue-specific protein interaction networks for ten main types of tissues in the human body. RESULTS: Commonly expressed proteins are under more intensive but lower-cost miRNAs control than proteins with the tissue-specific expression. MiRNAs that target more commonly expressed genes usually regulate more tissue-specific genes. This is consistent with the previous finding that tissue-specific proteins tend to be functionally connected with commonly expressed proteins. But to a particular miRNA such a balance is not invariable among different tissues implying diverse tissue regulation modes executed by miRNAs. CONCLUSION: These results suggest miRNAs that interact with more commonly expressed genes can be expected to play important tissue-specific roles. |
| first_indexed | 2024-12-23T23:41:38Z |
| format | Article |
| id | doaj.art-ecabd565ba374b7d8293ab8f042ed033 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T23:41:38Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ecabd565ba374b7d8293ab8f042ed0332022-12-21T17:25:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0169e2539410.1371/journal.pone.0025394MicroRNA regulation and tissue-specific protein interaction network.Wenliang ZhuLei YangZhimin DuBACKGROUND: 'Fine-tuning' of protein abundance makes microRNAs (miRNAs) pervasively implicated in human biology. Although targeting many mRNAs endows the power of single miRNA to regulate complex biological processes, its functional roles in a particular tissue will be inevitably restricted because only a subset of its target genes is expressed. METHODS: Here, we analyze the characteristics of miRNA regulation upon target genes according to tissue-specific gene expression by constructing tissue-specific protein interaction networks for ten main types of tissues in the human body. RESULTS: Commonly expressed proteins are under more intensive but lower-cost miRNAs control than proteins with the tissue-specific expression. MiRNAs that target more commonly expressed genes usually regulate more tissue-specific genes. This is consistent with the previous finding that tissue-specific proteins tend to be functionally connected with commonly expressed proteins. But to a particular miRNA such a balance is not invariable among different tissues implying diverse tissue regulation modes executed by miRNAs. CONCLUSION: These results suggest miRNAs that interact with more commonly expressed genes can be expected to play important tissue-specific roles.http://europepmc.org/articles/PMC3181334?pdf=render |
| spellingShingle | Wenliang Zhu Lei Yang Zhimin Du MicroRNA regulation and tissue-specific protein interaction network. PLoS ONE |
| title | MicroRNA regulation and tissue-specific protein interaction network. |
| title_full | MicroRNA regulation and tissue-specific protein interaction network. |
| title_fullStr | MicroRNA regulation and tissue-specific protein interaction network. |
| title_full_unstemmed | MicroRNA regulation and tissue-specific protein interaction network. |
| title_short | MicroRNA regulation and tissue-specific protein interaction network. |
| title_sort | microrna regulation and tissue specific protein interaction network |
| url | http://europepmc.org/articles/PMC3181334?pdf=render |
| work_keys_str_mv | AT wenliangzhu micrornaregulationandtissuespecificproteininteractionnetwork AT leiyang micrornaregulationandtissuespecificproteininteractionnetwork AT zhimindu micrornaregulationandtissuespecificproteininteractionnetwork |