Salivary Leptin Levels in Children with Early Childhood Caries – An Interventional Study
Background: Early childhood caries (ECC) is a pathologic condition of multifactorial nature. The diagnosis of the same has been limited to clinical and radiographic aids with very little significance to assess its inflammatory component. objectives: The present study aims to evaluate the role of le...
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| Format: | Article |
| Language: | English |
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Cumhuriyet University
2022-12-01
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| Series: | Cumhuriyet Dental Journal |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/2361835 |
| _version_ | 1797760114416943104 |
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| author | Pratima R Mokashi Srikala Bhandary |
| author_facet | Pratima R Mokashi Srikala Bhandary |
| author_sort | Pratima R Mokashi |
| collection | DOAJ |
| description | Background: Early childhood caries (ECC) is a pathologic condition of multifactorial nature. The diagnosis of the same has been limited to clinical and radiographic aids with very little significance to assess its inflammatory component. objectives: The present study aims to evaluate the role of leptin, an adipocytokine as a non-invasive inflammatory biomarker in ECC.
Materials and Method: A total of 60 children between the age of (3-5) years were selected for the study. The study subjects were divided into three groups of 20 each including Group 1 as control, Group 2 with mild to moderate ECC and Group 3 with severe ECC. Saliva samples were taken from all subjects and collected again after 2 months following rehabilitative intervention. Levels of salivary leptin were determined using Enzyme-Linked Immunosorbent Assay (ELISA).
Results: Levels of salivary leptin were significantly associated with severity of dental caries. The intragroup comparisons of pre and post treatment levels of salivary leptin showed significant reductions in both mild to moderate ECC and severe ECC groups following caries control. Inter group evaluation between mild to moderate ECC and severe ECC post treatment showed statistically significant decline of leptin levels in comparison to baseline values.
Conclusion: There was a statistically significant decline in salivary leptin levels between the mild moderate and severe ECC group, after 2 months following caries control. Thus, leptin holds a potential to be recognized as a reliable future prognostic and diagnostic inflammatory marker in early childhood caries. |
| first_indexed | 2024-03-12T18:55:00Z |
| format | Article |
| id | doaj.art-ecac1746080746f58c80b7e3165bc82e |
| institution | Directory Open Access Journal |
| issn | 1302-5805 2146-2852 |
| language | English |
| last_indexed | 2024-03-12T18:55:00Z |
| publishDate | 2022-12-01 |
| publisher | Cumhuriyet University |
| record_format | Article |
| series | Cumhuriyet Dental Journal |
| spelling | doaj.art-ecac1746080746f58c80b7e3165bc82e2023-08-02T06:59:12ZengCumhuriyet UniversityCumhuriyet Dental Journal1302-58052146-28522022-12-0125430230810.7126/cumudj.11004492057Salivary Leptin Levels in Children with Early Childhood Caries – An Interventional StudyPratima R Mokashi0Srikala Bhandary1AB Shetty Memorial Institute of Dental Sciences (ABSMIDS),AB Shetty Memorial Institute of Dental SciencesBackground: Early childhood caries (ECC) is a pathologic condition of multifactorial nature. The diagnosis of the same has been limited to clinical and radiographic aids with very little significance to assess its inflammatory component. objectives: The present study aims to evaluate the role of leptin, an adipocytokine as a non-invasive inflammatory biomarker in ECC. Materials and Method: A total of 60 children between the age of (3-5) years were selected for the study. The study subjects were divided into three groups of 20 each including Group 1 as control, Group 2 with mild to moderate ECC and Group 3 with severe ECC. Saliva samples were taken from all subjects and collected again after 2 months following rehabilitative intervention. Levels of salivary leptin were determined using Enzyme-Linked Immunosorbent Assay (ELISA). Results: Levels of salivary leptin were significantly associated with severity of dental caries. The intragroup comparisons of pre and post treatment levels of salivary leptin showed significant reductions in both mild to moderate ECC and severe ECC groups following caries control. Inter group evaluation between mild to moderate ECC and severe ECC post treatment showed statistically significant decline of leptin levels in comparison to baseline values. Conclusion: There was a statistically significant decline in salivary leptin levels between the mild moderate and severe ECC group, after 2 months following caries control. Thus, leptin holds a potential to be recognized as a reliable future prognostic and diagnostic inflammatory marker in early childhood caries.https://dergipark.org.tr/tr/download/article-file/2361835salivary leptinelisabiomarker |
| spellingShingle | Pratima R Mokashi Srikala Bhandary Salivary Leptin Levels in Children with Early Childhood Caries – An Interventional Study Cumhuriyet Dental Journal salivary leptin elisa biomarker |
| title | Salivary Leptin Levels in Children with Early Childhood Caries – An Interventional Study |
| title_full | Salivary Leptin Levels in Children with Early Childhood Caries – An Interventional Study |
| title_fullStr | Salivary Leptin Levels in Children with Early Childhood Caries – An Interventional Study |
| title_full_unstemmed | Salivary Leptin Levels in Children with Early Childhood Caries – An Interventional Study |
| title_short | Salivary Leptin Levels in Children with Early Childhood Caries – An Interventional Study |
| title_sort | salivary leptin levels in children with early childhood caries an interventional study |
| topic | salivary leptin elisa biomarker |
| url | https://dergipark.org.tr/tr/download/article-file/2361835 |
| work_keys_str_mv | AT pratimarmokashi salivaryleptinlevelsinchildrenwithearlychildhoodcariesaninterventionalstudy AT srikalabhandary salivaryleptinlevelsinchildrenwithearlychildhoodcariesaninterventionalstudy |