The potential role of miRNA in regulating macrophage polarization
Macrophage polarization is a dynamic process determining the outcome of various physiological and pathological situations through inducing pro-inflammatory responses or resolving inflammation via exerting anti-inflammatory effects. The miRNAs are epigenetic regulators of different biologic pathways...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-11-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023088230 |
| _version_ | 1797429881224560640 |
|---|---|
| author | Shaho Khayati Sajad Dehnavi Mahvash Sadeghi Jalil Tavakol Afshari Seyed-Alireza Esmaeili Mojgan Mohammadi |
| author_facet | Shaho Khayati Sajad Dehnavi Mahvash Sadeghi Jalil Tavakol Afshari Seyed-Alireza Esmaeili Mojgan Mohammadi |
| author_sort | Shaho Khayati |
| collection | DOAJ |
| description | Macrophage polarization is a dynamic process determining the outcome of various physiological and pathological situations through inducing pro-inflammatory responses or resolving inflammation via exerting anti-inflammatory effects. The miRNAs are epigenetic regulators of different biologic pathways that target transcription factors and signaling molecules to promote macrophage phenotype transition and regulate immune responses. Modulating the macrophage activation, differentiation, and polarization by miRNAs is crucial for immune responses in response to microenvironmental signals and under various physiological and pathological conditions. In term of clinical significance, regulating macrophage polarization via miRNAs could be utilized for inflammation control. Also, understanding the role of miRNAs in macrophage polarization can provide insights into diagnostic strategies associated with dysregulated miRNAs and for developing macrophage-centered therapeutic methods. In this case, targeting miRNAs to further regulate of macrophage polarization may become an efficient strategy for treating immune-associated disorders. The current review investigated and categorized various miRNAs directly or indirectly involved in macrophage polarization by targeting different transcription factors and signaling pathways. In addition, prospects for regulating macrophage polarization via miRNA as a therapeutic choice that could be implicated in various pathological conditions, including cancer or inflammation-mediated injuries, were discussed. |
| first_indexed | 2024-03-09T09:19:19Z |
| format | Article |
| id | doaj.art-ecac990639c24ea196f06bbffa2e9034 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-09T09:19:19Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-ecac990639c24ea196f06bbffa2e90342023-12-02T07:03:25ZengElsevierHeliyon2405-84402023-11-01911e21615The potential role of miRNA in regulating macrophage polarizationShaho Khayati0Sajad Dehnavi1Mahvash Sadeghi2Jalil Tavakol Afshari3Seyed-Alireza Esmaeili4Mojgan Mohammadi5Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranImmunology Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranImmunology Research Center, Mashhad University of Medical Sciences, Mashhad, IranImmunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Immunology Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranImmunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Corresponding author.Macrophage polarization is a dynamic process determining the outcome of various physiological and pathological situations through inducing pro-inflammatory responses or resolving inflammation via exerting anti-inflammatory effects. The miRNAs are epigenetic regulators of different biologic pathways that target transcription factors and signaling molecules to promote macrophage phenotype transition and regulate immune responses. Modulating the macrophage activation, differentiation, and polarization by miRNAs is crucial for immune responses in response to microenvironmental signals and under various physiological and pathological conditions. In term of clinical significance, regulating macrophage polarization via miRNAs could be utilized for inflammation control. Also, understanding the role of miRNAs in macrophage polarization can provide insights into diagnostic strategies associated with dysregulated miRNAs and for developing macrophage-centered therapeutic methods. In this case, targeting miRNAs to further regulate of macrophage polarization may become an efficient strategy for treating immune-associated disorders. The current review investigated and categorized various miRNAs directly or indirectly involved in macrophage polarization by targeting different transcription factors and signaling pathways. In addition, prospects for regulating macrophage polarization via miRNA as a therapeutic choice that could be implicated in various pathological conditions, including cancer or inflammation-mediated injuries, were discussed.http://www.sciencedirect.com/science/article/pii/S2405844023088230Macrophage polarizationmiRNAM1 classical phenotypeM2 alternative phenotypeInflammationTranscription factor |
| spellingShingle | Shaho Khayati Sajad Dehnavi Mahvash Sadeghi Jalil Tavakol Afshari Seyed-Alireza Esmaeili Mojgan Mohammadi The potential role of miRNA in regulating macrophage polarization Heliyon Macrophage polarization miRNA M1 classical phenotype M2 alternative phenotype Inflammation Transcription factor |
| title | The potential role of miRNA in regulating macrophage polarization |
| title_full | The potential role of miRNA in regulating macrophage polarization |
| title_fullStr | The potential role of miRNA in regulating macrophage polarization |
| title_full_unstemmed | The potential role of miRNA in regulating macrophage polarization |
| title_short | The potential role of miRNA in regulating macrophage polarization |
| title_sort | potential role of mirna in regulating macrophage polarization |
| topic | Macrophage polarization miRNA M1 classical phenotype M2 alternative phenotype Inflammation Transcription factor |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023088230 |
| work_keys_str_mv | AT shahokhayati thepotentialroleofmirnainregulatingmacrophagepolarization AT sajaddehnavi thepotentialroleofmirnainregulatingmacrophagepolarization AT mahvashsadeghi thepotentialroleofmirnainregulatingmacrophagepolarization AT jaliltavakolafshari thepotentialroleofmirnainregulatingmacrophagepolarization AT seyedalirezaesmaeili thepotentialroleofmirnainregulatingmacrophagepolarization AT mojganmohammadi thepotentialroleofmirnainregulatingmacrophagepolarization AT shahokhayati potentialroleofmirnainregulatingmacrophagepolarization AT sajaddehnavi potentialroleofmirnainregulatingmacrophagepolarization AT mahvashsadeghi potentialroleofmirnainregulatingmacrophagepolarization AT jaliltavakolafshari potentialroleofmirnainregulatingmacrophagepolarization AT seyedalirezaesmaeili potentialroleofmirnainregulatingmacrophagepolarization AT mojganmohammadi potentialroleofmirnainregulatingmacrophagepolarization |