Effects of the Autophagy-Inhibiting Agent Chloroquine on Acute Myeloid Leukemia Cells; Characterization of Patient Heterogeneity
Autophagy is a highly conserved cellular degradation process that prevents cell damage and promotes cell survival, and clinical efforts have exploited autophagy inhibition as a therapeutic strategy in cancer. Chloroquine is a well-known antimalarial agent that inhibits late-stage autophagy. We evalu...
Main Authors: | Ida Sofie Grønningsæter, Håkon Reikvam, Elise Aasebø, Sushma Bartaula-Brevik, Maria Hernandez-Valladares, Frode Selheim, Frode S. Berven, Tor Henrik Tvedt, Øystein Bruserud, Kimberley Joanne Hatfield |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-08-01
|
Series: | Journal of Personalized Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2075-4426/11/8/779 |
Similar Items
-
Targeting Cellular Metabolism in Acute Myeloid Leukemia and the Role of Patient Heterogeneity
by: Ida Sofie Grønningsæter, et al.
Published: (2020-05-01) -
The Capacity of Long-Term in Vitro Proliferation of Acute Myeloid Leukemia Cells Supported Only by Exogenous Cytokines Is Associated with a Patient Subset with Adverse Outcome
by: Annette K. Brenner, et al.
Published: (2019-01-01) -
Patient Heterogeneity in Acute Myeloid Leukemia: Leukemic Cell Communication by Release of Soluble Mediators and Its Effects on Mesenchymal Stem Cells
by: Elise Aasebø, et al.
Published: (2021-10-01) -
Proteomic Studies of Primary Acute Myeloid Leukemia Cells Derived from Patients Before and during Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid and Valproic Acid
by: Maria Hernandez-Valladares, et al.
Published: (2021-04-01) -
Vacuolar ATPase Is a Possible Therapeutic Target in Acute Myeloid Leukemia: Focus on Patient Heterogeneity and Treatment Toxicity
by: Sushma Bartaula-Brevik, et al.
Published: (2023-08-01)