Changes in the Maternal Serum Inflammatory Parameters of Pregnant Women with Epilepsy
Objective:This study investigated the third-trimester maternal serum inflammatory status of pregnant women with epilepsy (PWWE).Methods:One hundred-two PWWE and 102 healthy pregnant women were included in the study. Data were retrospectively collected from hospital records between May 2020 and 2023....
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2023-09-01
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| Series: | Archives of Epilepsy |
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http://archepilepsy.org/archives/archive-detail/article-preview/changes-in-the-maternal-serum-nflammatory-paramete/62168
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| author | Bergen Laleli Koç Duygu Tuğrul Ersak Özgecan Üçyıldız Güray Koç Onur Özkavak Özgür Kara Dilek Şahin |
| author_facet | Bergen Laleli Koç Duygu Tuğrul Ersak Özgecan Üçyıldız Güray Koç Onur Özkavak Özgür Kara Dilek Şahin |
| author_sort | Bergen Laleli Koç |
| collection | DOAJ |
| description | Objective:This study investigated the third-trimester maternal serum inflammatory status of pregnant women with epilepsy (PWWE).Methods:One hundred-two PWWE and 102 healthy pregnant women were included in the study. Data were retrospectively collected from hospital records between May 2020 and 2023. The results of monocyte, neutrophil, lymphocyte, platelet counts, neutrophil-to-lymphocyte ratio (NLR), and serum C-reactive protein (CRP) levels were recorded. The systemic immune inflammation index (SII) and systemic inflammation response index (SIRI) were calculated. The presence of seizures and receiving antiseizure medications during pregnancy were recorded.Results:Gestational age at delivery and birth weights of neonates were significantly lower in the epilepsy group than in the control group (p<0.001). The median NLR was 4.79 (2.36-10.50) in the polytherapy group and 2.87 (2.40-4.05) in the drug-free group, and this value was found to be statistically higher in the polytherapy group (p=0.025). No statistical significance was observed for NLR, CRP, SII, and SIRI values between the epilepsy group and the control group (p>0.05).Conclusion:This study revealed that maternal serum inflammatory parameters did not differ between PWWE and healthy pregnant women. Having epileptic seizures or being seizure-free during pregnancy did not alter the maternal serum inflammatory status. Prospective large population studies conducted in the postictal acute and interictal phases are needed to reveal the effect of seizures on the inflammatory process in PWWE. |
| first_indexed | 2024-03-11T21:50:59Z |
| format | Article |
| id | doaj.art-ecadc175dc1647288b69f3842b64c741 |
| institution | Directory Open Access Journal |
| issn | 2792-0550 |
| language | English |
| last_indexed | 2024-03-11T21:50:59Z |
| publishDate | 2023-09-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Archives of Epilepsy |
| spelling | doaj.art-ecadc175dc1647288b69f3842b64c7412023-09-26T09:01:53ZengGalenos YayineviArchives of Epilepsy2792-05502023-09-01293798210.4274/ArchEpilepsy.2023.2310013049054Changes in the Maternal Serum Inflammatory Parameters of Pregnant Women with EpilepsyBergen Laleli Koç0Duygu Tuğrul Ersak1Özgecan Üçyıldız2Güray Koç3Onur Özkavak4Özgür Kara5Dilek Şahin6 Ankara Bilkent City Hospital, Clinic of Obstetrics and Gynecology, Division of Perinatology, Ankara, Turkey Ankara Bilkent City Hospital, Clinic of Obstetrics and Gynecology, Division of Perinatology, Ankara, Turkey Ankara Bilkent City Hospital, Clinic of Obstetrics and Gynecology, Division of Perinatology, Ankara, Turkey University of Health Sciences Turkey, Ankara Bilkent City Hospital, Clinic of Neurology, Ankara, Turkey Ankara Bilkent City Hospital, Clinic of Obstetrics and Gynecology, Division of Perinatology, Ankara, Turkey Ankara Bilkent City Hospital, Clinic of Obstetrics and Gynecology, Division of Perinatology, Ankara, Turkey University of Health Sciences Turkey, Ankara Bilkent City Hospital, Clinic of Obstetrics and Gynecology, Division of Perinatology, Ankara, Turkey Objective:This study investigated the third-trimester maternal serum inflammatory status of pregnant women with epilepsy (PWWE).Methods:One hundred-two PWWE and 102 healthy pregnant women were included in the study. Data were retrospectively collected from hospital records between May 2020 and 2023. The results of monocyte, neutrophil, lymphocyte, platelet counts, neutrophil-to-lymphocyte ratio (NLR), and serum C-reactive protein (CRP) levels were recorded. The systemic immune inflammation index (SII) and systemic inflammation response index (SIRI) were calculated. The presence of seizures and receiving antiseizure medications during pregnancy were recorded.Results:Gestational age at delivery and birth weights of neonates were significantly lower in the epilepsy group than in the control group (p<0.001). The median NLR was 4.79 (2.36-10.50) in the polytherapy group and 2.87 (2.40-4.05) in the drug-free group, and this value was found to be statistically higher in the polytherapy group (p=0.025). No statistical significance was observed for NLR, CRP, SII, and SIRI values between the epilepsy group and the control group (p>0.05).Conclusion:This study revealed that maternal serum inflammatory parameters did not differ between PWWE and healthy pregnant women. Having epileptic seizures or being seizure-free during pregnancy did not alter the maternal serum inflammatory status. Prospective large population studies conducted in the postictal acute and interictal phases are needed to reveal the effect of seizures on the inflammatory process in PWWE. http://archepilepsy.org/archives/archive-detail/article-preview/changes-in-the-maternal-serum-nflammatory-paramete/62168 epilepsyinflammationpregnancy |
| spellingShingle | Bergen Laleli Koç Duygu Tuğrul Ersak Özgecan Üçyıldız Güray Koç Onur Özkavak Özgür Kara Dilek Şahin Changes in the Maternal Serum Inflammatory Parameters of Pregnant Women with Epilepsy Archives of Epilepsy epilepsy inflammation pregnancy |
| title | Changes in the Maternal Serum Inflammatory Parameters of Pregnant Women with Epilepsy |
| title_full | Changes in the Maternal Serum Inflammatory Parameters of Pregnant Women with Epilepsy |
| title_fullStr | Changes in the Maternal Serum Inflammatory Parameters of Pregnant Women with Epilepsy |
| title_full_unstemmed | Changes in the Maternal Serum Inflammatory Parameters of Pregnant Women with Epilepsy |
| title_short | Changes in the Maternal Serum Inflammatory Parameters of Pregnant Women with Epilepsy |
| title_sort | changes in the maternal serum inflammatory parameters of pregnant women with epilepsy |
| topic | epilepsy inflammation pregnancy |
| url |
http://archepilepsy.org/archives/archive-detail/article-preview/changes-in-the-maternal-serum-nflammatory-paramete/62168
|
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