UV-B Filter Octylmethoxycinnamate Is a Modulator of the Serotonin and Histamine Receptors in Human Umbilical Arteries
Every day, people use personal care products containing UV filters. Although their use initially showed a protective role, toxicity is a concern for human health as several UV filters are endocrine-disrupting chemicals (EDCs). Exposure to EDCs may induce cardiovascular diseases and can affect the he...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/5/1054 |
| _version_ | 1797501410916433920 |
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| author | Margarida Lorigo Carla Quintaneiro Luiza Breitenfeld Elisa Cairrao |
| author_facet | Margarida Lorigo Carla Quintaneiro Luiza Breitenfeld Elisa Cairrao |
| author_sort | Margarida Lorigo |
| collection | DOAJ |
| description | Every day, people use personal care products containing UV filters. Although their use initially showed a protective role, toxicity is a concern for human health as several UV filters are endocrine-disrupting chemicals (EDCs). Exposure to EDCs may induce cardiovascular diseases and can affect the health of sensitive people, such as pregnant women. Currently, the world’s most widely used UV-B filter is octylmethoxycinnamate (OMC), an EDC. However, the disruptive effects on pregnant women are little known. The present work proposed to understand how long-term exposure to OMC affects vascular homeostasis. Endothelium-denuded human umbilical artery (HUA) rings were incubated in an organ bath system. Long-term effects of exposure to OMC (0.001–50 μmol/L) were evaluated on the contractile responses of HUA to the application of the contractile agents, serotonin (5-HT) and histamine (Hist). To investigate in more detail the vascular mode of action of OMC, through which it impairs the vascular homeostasis of HUA, the activity and expression of different 5-HT and Hist-receptors involved in contractility processes were studied. Our findings pointed out an increase in the reactivity of HUA to 5-HT and Hist due to OMC exposure. These alterations in reactivity may be precursors of preeclampsia development and/or gestational hypertension. |
| first_indexed | 2024-03-10T03:18:00Z |
| format | Article |
| id | doaj.art-ecaeeafbf7a94317860da23410e9d7f8 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T03:18:00Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-ecaeeafbf7a94317860da23410e9d7f82023-11-23T10:10:22ZengMDPI AGBiomedicines2227-90592022-05-01105105410.3390/biomedicines10051054UV-B Filter Octylmethoxycinnamate Is a Modulator of the Serotonin and Histamine Receptors in Human Umbilical ArteriesMargarida Lorigo0Carla Quintaneiro1Luiza Breitenfeld2Elisa Cairrao3CICS-UBI, Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, PortugalDepartment of Biology & CESAM (Centre for Environmental and Marine Studies), University of Aveiro, 3810-193 Aveiro, PortugalCICS-UBI, Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, PortugalCICS-UBI, Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, PortugalEvery day, people use personal care products containing UV filters. Although their use initially showed a protective role, toxicity is a concern for human health as several UV filters are endocrine-disrupting chemicals (EDCs). Exposure to EDCs may induce cardiovascular diseases and can affect the health of sensitive people, such as pregnant women. Currently, the world’s most widely used UV-B filter is octylmethoxycinnamate (OMC), an EDC. However, the disruptive effects on pregnant women are little known. The present work proposed to understand how long-term exposure to OMC affects vascular homeostasis. Endothelium-denuded human umbilical artery (HUA) rings were incubated in an organ bath system. Long-term effects of exposure to OMC (0.001–50 μmol/L) were evaluated on the contractile responses of HUA to the application of the contractile agents, serotonin (5-HT) and histamine (Hist). To investigate in more detail the vascular mode of action of OMC, through which it impairs the vascular homeostasis of HUA, the activity and expression of different 5-HT and Hist-receptors involved in contractility processes were studied. Our findings pointed out an increase in the reactivity of HUA to 5-HT and Hist due to OMC exposure. These alterations in reactivity may be precursors of preeclampsia development and/or gestational hypertension.https://www.mdpi.com/2227-9059/10/5/1054personal care productendocrine-disrupting chemicalpregnant womenpreeclampsiagestational hypertension |
| spellingShingle | Margarida Lorigo Carla Quintaneiro Luiza Breitenfeld Elisa Cairrao UV-B Filter Octylmethoxycinnamate Is a Modulator of the Serotonin and Histamine Receptors in Human Umbilical Arteries Biomedicines personal care product endocrine-disrupting chemical pregnant women preeclampsia gestational hypertension |
| title | UV-B Filter Octylmethoxycinnamate Is a Modulator of the Serotonin and Histamine Receptors in Human Umbilical Arteries |
| title_full | UV-B Filter Octylmethoxycinnamate Is a Modulator of the Serotonin and Histamine Receptors in Human Umbilical Arteries |
| title_fullStr | UV-B Filter Octylmethoxycinnamate Is a Modulator of the Serotonin and Histamine Receptors in Human Umbilical Arteries |
| title_full_unstemmed | UV-B Filter Octylmethoxycinnamate Is a Modulator of the Serotonin and Histamine Receptors in Human Umbilical Arteries |
| title_short | UV-B Filter Octylmethoxycinnamate Is a Modulator of the Serotonin and Histamine Receptors in Human Umbilical Arteries |
| title_sort | uv b filter octylmethoxycinnamate is a modulator of the serotonin and histamine receptors in human umbilical arteries |
| topic | personal care product endocrine-disrupting chemical pregnant women preeclampsia gestational hypertension |
| url | https://www.mdpi.com/2227-9059/10/5/1054 |
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