Blueberry Consumption and Changes in Obesity and Diabetes Mellitus Outcomes: A Systematic Review
Low-grade inflammation and oxidative stress are key mechanisms involved in obesity and related disorders. Polyphenols from blueberry (BB) and bilberries (BiB) might protect against oxidative damage and inflammation. To summarize the effects of BiB or BB consumption in parameters related to obesity a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/1/19 |
| _version_ | 1797438831881879552 |
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| author | Mayara Souza de Oliveira Felipe Mateus Pellenz Bianca Marmontel de Souza Daisy Crispim |
| author_facet | Mayara Souza de Oliveira Felipe Mateus Pellenz Bianca Marmontel de Souza Daisy Crispim |
| author_sort | Mayara Souza de Oliveira |
| collection | DOAJ |
| description | Low-grade inflammation and oxidative stress are key mechanisms involved in obesity and related disorders. Polyphenols from blueberry (BB) and bilberries (BiB) might protect against oxidative damage and inflammation. To summarize the effects of BiB or BB consumption in parameters related to obesity and its comorbidities, a search of the literature was performed in PubMed, Embase, and Cochrane Library repositories to identify all studies that evaluated associations of whole BB or BiB with obesity and associated disorders. Thirty-one studies were eligible for inclusion in this review: eight clinical trials and 23 animal studies. In humans, BB consumption only consistently decreased oxidative stress and improved endothelial function. In rodents, BB or BiB consumption caused positive effects on glucose tolerance, nuclear factor-kappa B (Nf-κb) activity, oxidative stress, and triglyceride (TG) content in the liver and hepatic steatosis. The high content of anthocyanins present in BB and BiB seems to attenuate oxidative stress. The decrease in oxidative stress may have a positive impact on glucose tolerance and endothelial function. Moreover, in rodents, these berries seem to protect against hepatic steatosis, through the decreased accumulation of hepatic TGs. BB and BiB might also attenuate inflammation by decreasing Nf-κb activity and immune cell recruitment into the adipose tissue. |
| first_indexed | 2024-03-09T11:43:59Z |
| format | Article |
| id | doaj.art-ecb02e0bb48544d19c3bc3703f0bf8fa |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T11:43:59Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-ecb02e0bb48544d19c3bc3703f0bf8fa2023-11-30T23:27:43ZengMDPI AGMetabolites2218-19892022-12-011311910.3390/metabo13010019Blueberry Consumption and Changes in Obesity and Diabetes Mellitus Outcomes: A Systematic ReviewMayara Souza de Oliveira0Felipe Mateus Pellenz1Bianca Marmontel de Souza2Daisy Crispim3Endocrinology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, BrazilEndocrinology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, BrazilGraduate Program in Medical Sciences: Endocrinology, Faculty of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre 90010-150, RS, BrazilEndocrinology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, BrazilLow-grade inflammation and oxidative stress are key mechanisms involved in obesity and related disorders. Polyphenols from blueberry (BB) and bilberries (BiB) might protect against oxidative damage and inflammation. To summarize the effects of BiB or BB consumption in parameters related to obesity and its comorbidities, a search of the literature was performed in PubMed, Embase, and Cochrane Library repositories to identify all studies that evaluated associations of whole BB or BiB with obesity and associated disorders. Thirty-one studies were eligible for inclusion in this review: eight clinical trials and 23 animal studies. In humans, BB consumption only consistently decreased oxidative stress and improved endothelial function. In rodents, BB or BiB consumption caused positive effects on glucose tolerance, nuclear factor-kappa B (Nf-κb) activity, oxidative stress, and triglyceride (TG) content in the liver and hepatic steatosis. The high content of anthocyanins present in BB and BiB seems to attenuate oxidative stress. The decrease in oxidative stress may have a positive impact on glucose tolerance and endothelial function. Moreover, in rodents, these berries seem to protect against hepatic steatosis, through the decreased accumulation of hepatic TGs. BB and BiB might also attenuate inflammation by decreasing Nf-κb activity and immune cell recruitment into the adipose tissue.https://www.mdpi.com/2218-1989/13/1/19<i>Vaccinium</i> spp.blueberrybilberryobesitymetabolic syndromediet-induced obesity |
| spellingShingle | Mayara Souza de Oliveira Felipe Mateus Pellenz Bianca Marmontel de Souza Daisy Crispim Blueberry Consumption and Changes in Obesity and Diabetes Mellitus Outcomes: A Systematic Review Metabolites <i>Vaccinium</i> spp. blueberry bilberry obesity metabolic syndrome diet-induced obesity |
| title | Blueberry Consumption and Changes in Obesity and Diabetes Mellitus Outcomes: A Systematic Review |
| title_full | Blueberry Consumption and Changes in Obesity and Diabetes Mellitus Outcomes: A Systematic Review |
| title_fullStr | Blueberry Consumption and Changes in Obesity and Diabetes Mellitus Outcomes: A Systematic Review |
| title_full_unstemmed | Blueberry Consumption and Changes in Obesity and Diabetes Mellitus Outcomes: A Systematic Review |
| title_short | Blueberry Consumption and Changes in Obesity and Diabetes Mellitus Outcomes: A Systematic Review |
| title_sort | blueberry consumption and changes in obesity and diabetes mellitus outcomes a systematic review |
| topic | <i>Vaccinium</i> spp. blueberry bilberry obesity metabolic syndrome diet-induced obesity |
| url | https://www.mdpi.com/2218-1989/13/1/19 |
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