Successful treatment of linezolid-induced severe lactic acidosis with continuous venovenous hemodiafiltration: A case report
Linezolid is an oxazolidinone antibiotic. Linezolid-associated lactic acidosis has been reported in 6.8% of linezolid-treated patients. Lactic acidosis is associated with poor clinical outcomes, with high blood lactate levels resulting in organ dysfunction and mortality. This case report describes t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-02-01
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| Series: | Saudi Pharmaceutical Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S131901642100270X |
| _version_ | 1798024169485500416 |
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| author | Naiju Zhang Fan Zhang Zhong Chen Rui Huang Juan Xia Jinchun Liu |
| author_facet | Naiju Zhang Fan Zhang Zhong Chen Rui Huang Juan Xia Jinchun Liu |
| author_sort | Naiju Zhang |
| collection | DOAJ |
| description | Linezolid is an oxazolidinone antibiotic. Linezolid-associated lactic acidosis has been reported in 6.8% of linezolid-treated patients. Lactic acidosis is associated with poor clinical outcomes, with high blood lactate levels resulting in organ dysfunction and mortality. This case report describes the development of lactic acidosis in a 64-year-old Chinese woman who had received 33 days of treatment with antituberculosis drugs and 28 days of treatment with oral linezolid for tuberculous meningitis. Severe lactic acidosis was reversed by withdrawing antituberculosis drugs and using continuous venovenous hemodiafiltration (CVVH). When the patient's condition was stable, she was transferred to the infectious disease department, and antituberculosis drugs, with the exception of linezolid, were reintroduced. This did not result in recurrence of lactic acidosis. The causal relationship between lactic acidosis and linezolid was categorized as ‘probable’ on the Adverse Drug Reaction Probability Scale. This case demonstrates that CVVH has potential as an alternative to discontinuation of linezolid alone for rapid reversal of linezolid-associated severe lactic acidosis. |
| first_indexed | 2024-04-11T17:59:14Z |
| format | Article |
| id | doaj.art-ecb0cf90a360423f8e02cefc52188485 |
| institution | Directory Open Access Journal |
| issn | 1319-0164 |
| language | English |
| last_indexed | 2024-04-11T17:59:14Z |
| publishDate | 2022-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Pharmaceutical Journal |
| spelling | doaj.art-ecb0cf90a360423f8e02cefc521884852022-12-22T04:10:35ZengElsevierSaudi Pharmaceutical Journal1319-01642022-02-01302108111Successful treatment of linezolid-induced severe lactic acidosis with continuous venovenous hemodiafiltration: A case reportNaiju Zhang0Fan Zhang1Zhong Chen2Rui Huang3Juan Xia4Jinchun Liu5Department of Pharmacy, Department of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Key Laboratory of Immunology in Chronic Diseases, The first Affiliated Hospital of Bengbu Medical College, Anhui, Bengbu, ChinaDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Jiangsu, Nanjing 210008, PR ChinaDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Jiangsu, Nanjing 210008, PR ChinaDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Jiangsu, Nanjing 210008, PR ChinaDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Jiangsu, Nanjing 210008, PR China; Corresponding authors at: Department of Pharmacy, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, NO.321 Zhongshan Road, Jiangsu, Nanjing 210008, PR China.Department of Pharmacy, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Medical Center for Clinical Pharmacy, Jiangsu, Nanjing 210008, PR China; Corresponding authors at: Department of Pharmacy, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, NO.321 Zhongshan Road, Jiangsu, Nanjing 210008, PR China.Linezolid is an oxazolidinone antibiotic. Linezolid-associated lactic acidosis has been reported in 6.8% of linezolid-treated patients. Lactic acidosis is associated with poor clinical outcomes, with high blood lactate levels resulting in organ dysfunction and mortality. This case report describes the development of lactic acidosis in a 64-year-old Chinese woman who had received 33 days of treatment with antituberculosis drugs and 28 days of treatment with oral linezolid for tuberculous meningitis. Severe lactic acidosis was reversed by withdrawing antituberculosis drugs and using continuous venovenous hemodiafiltration (CVVH). When the patient's condition was stable, she was transferred to the infectious disease department, and antituberculosis drugs, with the exception of linezolid, were reintroduced. This did not result in recurrence of lactic acidosis. The causal relationship between lactic acidosis and linezolid was categorized as ‘probable’ on the Adverse Drug Reaction Probability Scale. This case demonstrates that CVVH has potential as an alternative to discontinuation of linezolid alone for rapid reversal of linezolid-associated severe lactic acidosis.http://www.sciencedirect.com/science/article/pii/S131901642100270XLinezolidLactic acidosisCVVHCase report |
| spellingShingle | Naiju Zhang Fan Zhang Zhong Chen Rui Huang Juan Xia Jinchun Liu Successful treatment of linezolid-induced severe lactic acidosis with continuous venovenous hemodiafiltration: A case report Saudi Pharmaceutical Journal Linezolid Lactic acidosis CVVH Case report |
| title | Successful treatment of linezolid-induced severe lactic acidosis with continuous venovenous hemodiafiltration: A case report |
| title_full | Successful treatment of linezolid-induced severe lactic acidosis with continuous venovenous hemodiafiltration: A case report |
| title_fullStr | Successful treatment of linezolid-induced severe lactic acidosis with continuous venovenous hemodiafiltration: A case report |
| title_full_unstemmed | Successful treatment of linezolid-induced severe lactic acidosis with continuous venovenous hemodiafiltration: A case report |
| title_short | Successful treatment of linezolid-induced severe lactic acidosis with continuous venovenous hemodiafiltration: A case report |
| title_sort | successful treatment of linezolid induced severe lactic acidosis with continuous venovenous hemodiafiltration a case report |
| topic | Linezolid Lactic acidosis CVVH Case report |
| url | http://www.sciencedirect.com/science/article/pii/S131901642100270X |
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