Topical ketotifen treatment for allergic conjunctivitis: a systematic review and Meta-analysis
AIM: To assess the efficacy of ketotifen in treating allergic conjunctivitis. METHODS: A systematic search of systematic reviews and Meta-analyses was conducted on the PubMed and Web Science of Science until October 2021 to address this knowledge gap. Mean difference with 95%CI and P values were use...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2023-02-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/en_publish/2023/2/20230217.pdf |
| _version_ | 1811173573299011584 |
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| author | Xin-Yan Dou Wei Zhang |
| author_facet | Xin-Yan Dou Wei Zhang |
| author_sort | Xin-Yan Dou |
| collection | DOAJ |
| description | AIM: To assess the efficacy of ketotifen in treating allergic conjunctivitis. METHODS: A systematic search of systematic reviews and Meta-analyses was conducted on the PubMed and Web Science of Science until October 2021 to address this knowledge gap. Mean difference with 95%CI and P values were used to assess the efficacy of ketotifen. The heterogeneity (I2) was used to evaluate the impact of heterogeneity. RESULTS: Eight randomized controlled trials (RCTs) involving 1589 patients were included in this Meta-analysis. The results revealed that after treating with ketotifen, itching (MD=-0.91, 95%CI: -1.63 to -0.20, I2=94%, P=0.01), tearing (MD=-0.40, 95%CI: -0.61 to -0.18, I2=75%, P=0.0003) and total signs and symptoms (MD=-0.85, 95%CI: -1.12 to -0.58, I2=0, P<0.00001) showed better benefit effect compared to the placebo group. CONCLUSION: Topical ketotifen is an effective treatment for patients with allergic conjunctivitis. |
| first_indexed | 2024-04-10T17:49:12Z |
| format | Article |
| id | doaj.art-ecb195da821e4c4bbaf35081b1b1b772 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-04-10T17:49:12Z |
| publishDate | 2023-02-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-ecb195da821e4c4bbaf35081b1b1b7722023-02-03T03:11:48ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982023-02-0116228629210.18240/ijo.2023.02.1720230217Topical ketotifen treatment for allergic conjunctivitis: a systematic review and Meta-analysisXin-Yan Dou0Wei Zhang1Xin-Yan Dou. Department of Ophthalmology, Shanghai Wusong Central Hospital, Baoshan District, No.216 Mudanjiang Road, Baoshan District, Shanghai 200940, China. douxinyan0116@126.comDepartment of Ophthalmology, Shanghai Wusong Central Hospital, Shanghai 200940, ChinaAIM: To assess the efficacy of ketotifen in treating allergic conjunctivitis. METHODS: A systematic search of systematic reviews and Meta-analyses was conducted on the PubMed and Web Science of Science until October 2021 to address this knowledge gap. Mean difference with 95%CI and P values were used to assess the efficacy of ketotifen. The heterogeneity (I2) was used to evaluate the impact of heterogeneity. RESULTS: Eight randomized controlled trials (RCTs) involving 1589 patients were included in this Meta-analysis. The results revealed that after treating with ketotifen, itching (MD=-0.91, 95%CI: -1.63 to -0.20, I2=94%, P=0.01), tearing (MD=-0.40, 95%CI: -0.61 to -0.18, I2=75%, P=0.0003) and total signs and symptoms (MD=-0.85, 95%CI: -1.12 to -0.58, I2=0, P<0.00001) showed better benefit effect compared to the placebo group. CONCLUSION: Topical ketotifen is an effective treatment for patients with allergic conjunctivitis.http://ies.ijo.cn/en_publish/2023/2/20230217.pdfallergic conjunctivitisketotifenmeta-analysisolopatadine |
| spellingShingle | Xin-Yan Dou Wei Zhang Topical ketotifen treatment for allergic conjunctivitis: a systematic review and Meta-analysis International Journal of Ophthalmology allergic conjunctivitis ketotifen meta-analysis olopatadine |
| title | Topical ketotifen treatment for allergic conjunctivitis: a systematic review and Meta-analysis |
| title_full | Topical ketotifen treatment for allergic conjunctivitis: a systematic review and Meta-analysis |
| title_fullStr | Topical ketotifen treatment for allergic conjunctivitis: a systematic review and Meta-analysis |
| title_full_unstemmed | Topical ketotifen treatment for allergic conjunctivitis: a systematic review and Meta-analysis |
| title_short | Topical ketotifen treatment for allergic conjunctivitis: a systematic review and Meta-analysis |
| title_sort | topical ketotifen treatment for allergic conjunctivitis a systematic review and meta analysis |
| topic | allergic conjunctivitis ketotifen meta-analysis olopatadine |
| url | http://ies.ijo.cn/en_publish/2023/2/20230217.pdf |
| work_keys_str_mv | AT xinyandou topicalketotifentreatmentforallergicconjunctivitisasystematicreviewandmetaanalysis AT weizhang topicalketotifentreatmentforallergicconjunctivitisasystematicreviewandmetaanalysis |