Role of Surgery in Metastatic Melanoma and Review of Melanoma Molecular Characteristics

Role of Surgery in Metastatic Melanoma and Review of Melanoma Molecular Characteristics

We aimed to review the molecular characteristics of metastatic melanoma and the role of surgery in metastasectomy for metastatic melanoma. We performed a systematic literature search on PubMed to identify relevant studies focusing on several mutations, including NRAS, BRAF, NF1, MITF, PTEN, TP53, CD...

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Bibliographic Details
Main Authors: Kulkaew Sukniam, Harsheen K. Manaise, Kyle Popp, Reed Popp, Emmanuel Gabriel
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Cells
Subjects:
melanoma
mutation
surgery
metastatic melanoma
Online Access:https://www.mdpi.com/2073-4409/13/6/465
Description
Summary:We aimed to review the molecular characteristics of metastatic melanoma and the role of surgery in metastasectomy for metastatic melanoma. We performed a systematic literature search on PubMed to identify relevant studies focusing on several mutations, including NRAS, BRAF, NF1, MITF, PTEN, TP53, CDKN2A, TERT, TMB, EGFR, and c-KIT. This was performed in the context of metastatic melanoma and the role of metastasectomy in the metastatic melanoma population. A comprehensive review of these molecular characteristics is presented with a focus on their prognosis and role in surgical metastasectomy.
ISSN:2073-4409

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