Clinical characteristics of healthcare workers with SARS-CoV-2 infection after vaccination with BNT162b2 vaccine
Abstract Background The pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), had a significant impact worldwide. Vaccines against COVID-19 appear as a tool able to curb out mortality and reduce the circulation of the virus. Litt...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-022-07083-1 |
| _version_ | 1818941862743900160 |
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| author | Andrea Lombardi Giulia Renisi Dario Consonni Massimo Oggioni Patrizia Bono Sara Uceda Renteria Alessandra Piatti Angela Cecilia Pesatori Silvana Castaldi Antonio Muscatello Luciano Riboldi Ferruccio Ceriotti Andrea Gori Alessandra Bandera |
| author_facet | Andrea Lombardi Giulia Renisi Dario Consonni Massimo Oggioni Patrizia Bono Sara Uceda Renteria Alessandra Piatti Angela Cecilia Pesatori Silvana Castaldi Antonio Muscatello Luciano Riboldi Ferruccio Ceriotti Andrea Gori Alessandra Bandera |
| author_sort | Andrea Lombardi |
| collection | DOAJ |
| description | Abstract Background The pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), had a significant impact worldwide. Vaccines against COVID-19 appear as a tool able to curb out mortality and reduce the circulation of the virus. Little is known so far about the clinical characteristics of individuals who developed SARS-CoV-2 infection after having received the vaccination, as well as the temporal relationship between vaccine administration and symptoms onset. Methods Retrospective cohort study among the 3219 healthcare workers (HCWs) of the Fondazione IRCCS Ospedale Maggiore Policlinico of Milano who received a full immunization with the BNT162b2 vaccine and who developed SARS-CoV-2 infection (documented through positive RT-PCR on nasopharyngeal swab) in March–April 2021. Results Overall, we have identified 15 HCWs with SARS-CoV-2 infection after vaccination, 7 (46.7%) of them were male and the mean age was 38.4 years (SD 14). In 4 of them, the presence of SARS-CoV-2 anti-nucleocapsid (anti-N) antibodies was assessed before vaccination and resulted positive in 1 case. In all HCWs the presence of SARS-CoV-2 anti-spike (anti-S1) antibodies was assessed, on average 42.2 days after the completion of vaccination, with a mean value of 2055 U/mL (SD 1927.3). SARS-CoV-2 infection was ascertained on average 56.2 days after vaccination. The mean cycle threshold (Ct) of SARS-CoV-2 PCR was 26.4, the lineage was characterized in 9 HCWs. None of the HCWs reported a primary or secondary immunodeficiency. Regarding symptoms, they were reported only by 7 (46.7%) HCWs and appeared on average 55 days after the second dose of vaccination. Of those who reported symptoms, one (14.3%) had fever, 7 (100%) rhinitis/conjunctivitis, 4 (57.1%) taste and smell alterations, none had respiratory symptoms, 4 headache/arthralgia (57.1%) and 1 gastrointestinal symptom (14.3%). All symptoms disappeared in a few days and no other unclassified symptoms were reported. Conclusions Infections occurring after vaccination with the BNT162b2 vaccine are mostly asymptomatic and are not associated with the serum titre of anti-S1 antibodies. We did not find a predominance of specific viral variants, with several lineages represented. |
| first_indexed | 2024-12-20T07:02:17Z |
| format | Article |
| id | doaj.art-ecb3cb42eff0498c9e38f57bbe085579 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-20T07:02:17Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-ecb3cb42eff0498c9e38f57bbe0855792022-12-21T19:49:11ZengBMCBMC Infectious Diseases1471-23342022-01-012211510.1186/s12879-022-07083-1Clinical characteristics of healthcare workers with SARS-CoV-2 infection after vaccination with BNT162b2 vaccineAndrea Lombardi0Giulia Renisi1Dario Consonni2Massimo Oggioni3Patrizia Bono4Sara Uceda Renteria5Alessandra Piatti6Angela Cecilia Pesatori7Silvana Castaldi8Antonio Muscatello9Luciano Riboldi10Ferruccio Ceriotti11Andrea Gori12Alessandra Bandera13Infectious Diseases Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoInfectious Diseases Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoEpidemiology Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoClinical Laboratory, Foundation IRCCS Ca’ Granda Ospedale MaggioreClinical Laboratory, Foundation IRCCS Ca’ Granda Ospedale MaggioreClinical Laboratory, Foundation IRCCS Ca’ Granda Ospedale MaggioreMedical Direction, Foundation IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoEpidemiology Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoDepartment Biomedical Sciences for Health, University of MilanInfectious Diseases Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoOccupational Health Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoClinical Laboratory, Foundation IRCCS Ca’ Granda Ospedale MaggioreInfectious Diseases Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoInfectious Diseases Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoAbstract Background The pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), had a significant impact worldwide. Vaccines against COVID-19 appear as a tool able to curb out mortality and reduce the circulation of the virus. Little is known so far about the clinical characteristics of individuals who developed SARS-CoV-2 infection after having received the vaccination, as well as the temporal relationship between vaccine administration and symptoms onset. Methods Retrospective cohort study among the 3219 healthcare workers (HCWs) of the Fondazione IRCCS Ospedale Maggiore Policlinico of Milano who received a full immunization with the BNT162b2 vaccine and who developed SARS-CoV-2 infection (documented through positive RT-PCR on nasopharyngeal swab) in March–April 2021. Results Overall, we have identified 15 HCWs with SARS-CoV-2 infection after vaccination, 7 (46.7%) of them were male and the mean age was 38.4 years (SD 14). In 4 of them, the presence of SARS-CoV-2 anti-nucleocapsid (anti-N) antibodies was assessed before vaccination and resulted positive in 1 case. In all HCWs the presence of SARS-CoV-2 anti-spike (anti-S1) antibodies was assessed, on average 42.2 days after the completion of vaccination, with a mean value of 2055 U/mL (SD 1927.3). SARS-CoV-2 infection was ascertained on average 56.2 days after vaccination. The mean cycle threshold (Ct) of SARS-CoV-2 PCR was 26.4, the lineage was characterized in 9 HCWs. None of the HCWs reported a primary or secondary immunodeficiency. Regarding symptoms, they were reported only by 7 (46.7%) HCWs and appeared on average 55 days after the second dose of vaccination. Of those who reported symptoms, one (14.3%) had fever, 7 (100%) rhinitis/conjunctivitis, 4 (57.1%) taste and smell alterations, none had respiratory symptoms, 4 headache/arthralgia (57.1%) and 1 gastrointestinal symptom (14.3%). All symptoms disappeared in a few days and no other unclassified symptoms were reported. Conclusions Infections occurring after vaccination with the BNT162b2 vaccine are mostly asymptomatic and are not associated with the serum titre of anti-S1 antibodies. We did not find a predominance of specific viral variants, with several lineages represented.https://doi.org/10.1186/s12879-022-07083-1SARS-CoV-2COVID-19VaccinationSymptomsBNT162b2 |
| spellingShingle | Andrea Lombardi Giulia Renisi Dario Consonni Massimo Oggioni Patrizia Bono Sara Uceda Renteria Alessandra Piatti Angela Cecilia Pesatori Silvana Castaldi Antonio Muscatello Luciano Riboldi Ferruccio Ceriotti Andrea Gori Alessandra Bandera Clinical characteristics of healthcare workers with SARS-CoV-2 infection after vaccination with BNT162b2 vaccine BMC Infectious Diseases SARS-CoV-2 COVID-19 Vaccination Symptoms BNT162b2 |
| title | Clinical characteristics of healthcare workers with SARS-CoV-2 infection after vaccination with BNT162b2 vaccine |
| title_full | Clinical characteristics of healthcare workers with SARS-CoV-2 infection after vaccination with BNT162b2 vaccine |
| title_fullStr | Clinical characteristics of healthcare workers with SARS-CoV-2 infection after vaccination with BNT162b2 vaccine |
| title_full_unstemmed | Clinical characteristics of healthcare workers with SARS-CoV-2 infection after vaccination with BNT162b2 vaccine |
| title_short | Clinical characteristics of healthcare workers with SARS-CoV-2 infection after vaccination with BNT162b2 vaccine |
| title_sort | clinical characteristics of healthcare workers with sars cov 2 infection after vaccination with bnt162b2 vaccine |
| topic | SARS-CoV-2 COVID-19 Vaccination Symptoms BNT162b2 |
| url | https://doi.org/10.1186/s12879-022-07083-1 |
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