The immune modulatory effects of mitochondrial transplantation on cecal slurry model in rat

The immune modulatory effects of mitochondrial transplantation on cecal slurry model in rat

Abstract Background Sepsis has a high mortality rate, but no specific drug has been proven effective, prompting the development of new drugs. Immunologically, sepsis can involve hyperinflammation, immune paralysis, or both, which might pose challenges during drug development. Recently, mitochondrial...

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Bibliographic Details
Main Authors: Jung Wook Hwang, Min Ji Lee, Tae Nyoung Chung, Han A. Reum Lee, Jung Ho Lee, Seo Yoon Choi, Ye Jin Park, Chul Hee Kim, Isom Jin, Seong Hoon Kim, Hyo-Bum Kwak, Jun-Won Heo, Kwangmin Na, Sangchun Choi, Yong-Soo Choi, Kyuseok Kim
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Critical Care
Subjects:
Sepsis
Immune modulation
Hyperinflammation
Immune paralysis
Mitochondria transplantation
Mitochondria dysfunction
Online Access:https://doi.org/10.1186/s13054-020-03436-x

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