Protein Misfolding and Aggregation in Proteinopathies: Causes, Mechanism and Cellular Response
Proteins are central to life functions. Alterations in the structure of proteins are reflected in their function. Misfolded proteins and their aggregates present a significant risk to the cell. Cells have a diverse but integrated network of protection mechanisms. Streams of misfolded proteins that c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Diseases |
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| Online Access: | https://www.mdpi.com/2079-9721/11/1/30 |
| _version_ | 1797612370789400576 |
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| author | Mohammad Rehan Ajmal |
| author_facet | Mohammad Rehan Ajmal |
| author_sort | Mohammad Rehan Ajmal |
| collection | DOAJ |
| description | Proteins are central to life functions. Alterations in the structure of proteins are reflected in their function. Misfolded proteins and their aggregates present a significant risk to the cell. Cells have a diverse but integrated network of protection mechanisms. Streams of misfolded proteins that cells are continuously exposed to must be continually monitored by an elaborated network of molecular chaperones and protein degradation factors to control and contain protein misfolding problems. Aggregation inhibition properties of small molecules such as polyphenols are important as they possess other beneficial properties such as antioxidative, anti-inflammatory, and pro-autophagic properties and help neuroprotection. A candidate with such desired features is important for any possible treatment development for protein aggregation diseases. There is a need to study the protein misfolding phenomenon so that we can treat some of the worst kinds of human ailments related to protein misfolding and aggregation. |
| first_indexed | 2024-03-11T06:41:21Z |
| format | Article |
| id | doaj.art-ecb594aed65c4492887e82a355a6ba24 |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-03-11T06:41:21Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-ecb594aed65c4492887e82a355a6ba242023-11-17T10:36:34ZengMDPI AGDiseases2079-97212023-02-011113010.3390/diseases11010030Protein Misfolding and Aggregation in Proteinopathies: Causes, Mechanism and Cellular ResponseMohammad Rehan Ajmal0Physical Biochemistry Research Laboratory, Biochemistry Department, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi ArabiaProteins are central to life functions. Alterations in the structure of proteins are reflected in their function. Misfolded proteins and their aggregates present a significant risk to the cell. Cells have a diverse but integrated network of protection mechanisms. Streams of misfolded proteins that cells are continuously exposed to must be continually monitored by an elaborated network of molecular chaperones and protein degradation factors to control and contain protein misfolding problems. Aggregation inhibition properties of small molecules such as polyphenols are important as they possess other beneficial properties such as antioxidative, anti-inflammatory, and pro-autophagic properties and help neuroprotection. A candidate with such desired features is important for any possible treatment development for protein aggregation diseases. There is a need to study the protein misfolding phenomenon so that we can treat some of the worst kinds of human ailments related to protein misfolding and aggregation.https://www.mdpi.com/2079-9721/11/1/30protein aggregationamyloid diseasesaggregation inhibitioninflammationneurodegeneration |
| spellingShingle | Mohammad Rehan Ajmal Protein Misfolding and Aggregation in Proteinopathies: Causes, Mechanism and Cellular Response Diseases protein aggregation amyloid diseases aggregation inhibition inflammation neurodegeneration |
| title | Protein Misfolding and Aggregation in Proteinopathies: Causes, Mechanism and Cellular Response |
| title_full | Protein Misfolding and Aggregation in Proteinopathies: Causes, Mechanism and Cellular Response |
| title_fullStr | Protein Misfolding and Aggregation in Proteinopathies: Causes, Mechanism and Cellular Response |
| title_full_unstemmed | Protein Misfolding and Aggregation in Proteinopathies: Causes, Mechanism and Cellular Response |
| title_short | Protein Misfolding and Aggregation in Proteinopathies: Causes, Mechanism and Cellular Response |
| title_sort | protein misfolding and aggregation in proteinopathies causes mechanism and cellular response |
| topic | protein aggregation amyloid diseases aggregation inhibition inflammation neurodegeneration |
| url | https://www.mdpi.com/2079-9721/11/1/30 |
| work_keys_str_mv | AT mohammadrehanajmal proteinmisfoldingandaggregationinproteinopathiescausesmechanismandcellularresponse |