Preparation of Peptoid Antifreeze Agents and Their Structure–Property Relationship
The development of nontoxic and efficient antifreeze agents for organ cryopreservation is crucial. However, the research remains highly challenging. In this study, we designed and synthesized a series of peptoid oligomers using the solid-phase submonomer synthesis method by mimicking the amphiphilic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-04-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/16/7/990 |
| _version_ | 1797212118946152448 |
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| author | Kang Yang Di Liu Lei Feng Liugen Xu Yangang Jiang Xiran Shen Amjad Ali Jianwei Lu Li Guo |
| author_facet | Kang Yang Di Liu Lei Feng Liugen Xu Yangang Jiang Xiran Shen Amjad Ali Jianwei Lu Li Guo |
| author_sort | Kang Yang |
| collection | DOAJ |
| description | The development of nontoxic and efficient antifreeze agents for organ cryopreservation is crucial. However, the research remains highly challenging. In this study, we designed and synthesized a series of peptoid oligomers using the solid-phase submonomer synthesis method by mimicking the amphiphilic structures of antifreeze proteins (AFPs). The obtained peptoid oligomers showed excellent antifreeze properties, reducing the ice crystal growth rate and inhibiting ice recrystallization. The effects of the hydrophobicity and sequence of the peptoid side chains were also studied to reveal the structure–property relationship. The prepared peptoid oligomers were detected as non-cytotoxic and considered to be useful in the biological field. We hope that the peptoid oligomers presented in this study can provide effective strategies for the design of biological cryoprotectants for organ preservation in the future. |
| first_indexed | 2024-04-24T10:37:18Z |
| format | Article |
| id | doaj.art-ecb77809908d4d249085c2cdd0eb556b |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-04-24T10:37:18Z |
| publishDate | 2024-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-ecb77809908d4d249085c2cdd0eb556b2024-04-12T13:25:16ZengMDPI AGPolymers2073-43602024-04-0116799010.3390/polym16070990Preparation of Peptoid Antifreeze Agents and Their Structure–Property RelationshipKang Yang0Di Liu1Lei Feng2Liugen Xu3Yangang Jiang4Xiran Shen5Amjad Ali6Jianwei Lu7Li Guo8School of Materials Science & Engineering, Jiangsu University, Zhenjiang 212013, ChinaSchool of Materials Science & Engineering, Jiangsu University, Zhenjiang 212013, ChinaSchool of Materials Science & Engineering, Jiangsu University, Zhenjiang 212013, ChinaSchool of Materials Science & Engineering, Jiangsu University, Zhenjiang 212013, ChinaSchool of Materials Science & Engineering, Jiangsu University, Zhenjiang 212013, ChinaSchool of Materials Science & Engineering, Jiangsu University, Zhenjiang 212013, ChinaSchool of Materials Science & Engineering, Jiangsu University, Zhenjiang 212013, ChinaSchool of Materials Science & Engineering, Jiangsu University, Zhenjiang 212013, ChinaSchool of Materials Science & Engineering, Jiangsu University, Zhenjiang 212013, ChinaThe development of nontoxic and efficient antifreeze agents for organ cryopreservation is crucial. However, the research remains highly challenging. In this study, we designed and synthesized a series of peptoid oligomers using the solid-phase submonomer synthesis method by mimicking the amphiphilic structures of antifreeze proteins (AFPs). The obtained peptoid oligomers showed excellent antifreeze properties, reducing the ice crystal growth rate and inhibiting ice recrystallization. The effects of the hydrophobicity and sequence of the peptoid side chains were also studied to reveal the structure–property relationship. The prepared peptoid oligomers were detected as non-cytotoxic and considered to be useful in the biological field. We hope that the peptoid oligomers presented in this study can provide effective strategies for the design of biological cryoprotectants for organ preservation in the future.https://www.mdpi.com/2073-4360/16/7/990antifreeze agentpeptoidice recrystallization inhibition activity |
| spellingShingle | Kang Yang Di Liu Lei Feng Liugen Xu Yangang Jiang Xiran Shen Amjad Ali Jianwei Lu Li Guo Preparation of Peptoid Antifreeze Agents and Their Structure–Property Relationship Polymers antifreeze agent peptoid ice recrystallization inhibition activity |
| title | Preparation of Peptoid Antifreeze Agents and Their Structure–Property Relationship |
| title_full | Preparation of Peptoid Antifreeze Agents and Their Structure–Property Relationship |
| title_fullStr | Preparation of Peptoid Antifreeze Agents and Their Structure–Property Relationship |
| title_full_unstemmed | Preparation of Peptoid Antifreeze Agents and Their Structure–Property Relationship |
| title_short | Preparation of Peptoid Antifreeze Agents and Their Structure–Property Relationship |
| title_sort | preparation of peptoid antifreeze agents and their structure property relationship |
| topic | antifreeze agent peptoid ice recrystallization inhibition activity |
| url | https://www.mdpi.com/2073-4360/16/7/990 |
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