Liposomes for the Treatment of Brain Cancer—A Review
Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate targeted delivery across the blood–brain barrier (BBB). Additionally, strategies have been explored to synthesize liposom...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/16/8/1056 |
| _version_ | 1797583594368008192 |
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| author | Richu Raju Waad H. Abuwatfa William G. Pitt Ghaleb A. Husseini |
| author_facet | Richu Raju Waad H. Abuwatfa William G. Pitt Ghaleb A. Husseini |
| author_sort | Richu Raju |
| collection | DOAJ |
| description | Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate targeted delivery across the blood–brain barrier (BBB). Additionally, strategies have been explored to synthesize liposomes that respond to internal and/or external stimuli to release their payload controllably. Although research into liposomes for brain cancer treatment is still in its infancy, these systems have great potential to fundamentally change the drug delivery landscape. This review paper attempts to consolidate relevant literature regarding the delivery to the brain using nanocarriers, particularly liposomes. The paper first briefly explains conventional treatment modalities for cancer, followed by describing the blood–brain barrier and ways, challenges, and techniques involved in transporting drugs across the BBB. Various nanocarrier systems are introduced, with attention to liposomes, due to their ability to circumvent the challenges imposed by the BBB. Relevant studies involving liposomal systems researched to treat brain tumors are reviewed <i>in vitro, in vivo</i>, and clinical studies. Finally, the challenges associated with the use of liposomes to treat brain tumors and how they can be addressed are presented. |
| first_indexed | 2024-03-10T23:40:03Z |
| format | Article |
| id | doaj.art-ecba07e29c9c4431b13ac28a58ebb189 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T23:40:03Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-ecba07e29c9c4431b13ac28a58ebb1892023-11-19T02:33:12ZengMDPI AGPharmaceuticals1424-82472023-07-01168105610.3390/ph16081056Liposomes for the Treatment of Brain Cancer—A ReviewRichu Raju0Waad H. Abuwatfa1William G. Pitt2Ghaleb A. Husseini3Biomedical Engineering Program, College of Engineering, American University of Sharjah, Sharjah P.O. Box 26666, United Arab EmiratesMaterials Science and Engineering Ph.D. Program, College of Arts and Sciences, American University of Sharjah, Sharjah P.O. Box. 26666, United Arab EmiratesDepartment of Chemical Engineering, Brigham Young University, Provo, UT 84602, USABiomedical Engineering Program, College of Engineering, American University of Sharjah, Sharjah P.O. Box 26666, United Arab EmiratesDue to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate targeted delivery across the blood–brain barrier (BBB). Additionally, strategies have been explored to synthesize liposomes that respond to internal and/or external stimuli to release their payload controllably. Although research into liposomes for brain cancer treatment is still in its infancy, these systems have great potential to fundamentally change the drug delivery landscape. This review paper attempts to consolidate relevant literature regarding the delivery to the brain using nanocarriers, particularly liposomes. The paper first briefly explains conventional treatment modalities for cancer, followed by describing the blood–brain barrier and ways, challenges, and techniques involved in transporting drugs across the BBB. Various nanocarrier systems are introduced, with attention to liposomes, due to their ability to circumvent the challenges imposed by the BBB. Relevant studies involving liposomal systems researched to treat brain tumors are reviewed <i>in vitro, in vivo</i>, and clinical studies. Finally, the challenges associated with the use of liposomes to treat brain tumors and how they can be addressed are presented.https://www.mdpi.com/1424-8247/16/8/1056liposomesnanocarriersbraintargeted drug delivery |
| spellingShingle | Richu Raju Waad H. Abuwatfa William G. Pitt Ghaleb A. Husseini Liposomes for the Treatment of Brain Cancer—A Review Pharmaceuticals liposomes nanocarriers brain targeted drug delivery |
| title | Liposomes for the Treatment of Brain Cancer—A Review |
| title_full | Liposomes for the Treatment of Brain Cancer—A Review |
| title_fullStr | Liposomes for the Treatment of Brain Cancer—A Review |
| title_full_unstemmed | Liposomes for the Treatment of Brain Cancer—A Review |
| title_short | Liposomes for the Treatment of Brain Cancer—A Review |
| title_sort | liposomes for the treatment of brain cancer a review |
| topic | liposomes nanocarriers brain targeted drug delivery |
| url | https://www.mdpi.com/1424-8247/16/8/1056 |
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