Pre-retinal delivery of recombinant adeno-associated virus vector significantly improves retinal transduction efficiency

Pre-retinal delivery of recombinant adeno-associated virus vector significantly improves retinal transduction efficiency

Intravitreal injection is the most widely used injection technique for ocular gene delivery. However, vector diffusion is attenuated by physical barriers and neutralizing antibodies in the vitreous. The 13-lined ground squirrel (13-LGS), as in humans, has a larger relative vitreous body volume than...

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Bibliographic Details
Main Authors: Hanmeng Zhang, Benjamin S. Sajdak, Dana K. Merriman, Joseph Carroll, Daniel M. Lipinski
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
retina
gene therapy
AAV
posterior hyaloid membrane
pre-retinal
intravitreal
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121001078

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