Binge Eating (BE) and Obesity: Brain Activity and Psychological Measures before and after Roux-En-Y Gastric Bypass (RYGB)
Brain activity in response to food cues following Roux-En-Y Gastric Bypass (RYGB) in binge eating (BE) or non-binge eating (NB) individuals is understudied. Here, 15 RYGB (8 BE; 7 NB) and 13 no treatment (NT) (7 BE; 6 NB) women with obesity underwent fMRI imaging while viewing high and low energy de...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/17/3808 |
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| author | Shaunte Baboumian Lauren Puma Charles Swencionis Nerys M. Astbury Jennifer Ho Spiro P. Pantazatos Allan Geliebter |
| author_facet | Shaunte Baboumian Lauren Puma Charles Swencionis Nerys M. Astbury Jennifer Ho Spiro P. Pantazatos Allan Geliebter |
| author_sort | Shaunte Baboumian |
| collection | DOAJ |
| description | Brain activity in response to food cues following Roux-En-Y Gastric Bypass (RYGB) in binge eating (BE) or non-binge eating (NB) individuals is understudied. Here, 15 RYGB (8 BE; 7 NB) and 13 no treatment (NT) (7 BE; 6 NB) women with obesity underwent fMRI imaging while viewing high and low energy density food (HEF and LEF, respectively) and non-food (NF) visual cues. A region of interest (ROI) analysis compared BE participants to NB participants in those undergoing RYGB surgery pre-surgery and 4 months post. Results were corrected for multiple comparisons using liberal (<i>p</i> < 0.006 uncorrected) and stringent (<i>p</i> < 0.05 FDR corrected) thresholds. Four months following RYGB (vs. no treatment (NT) control), both BE and NB participants showed greater reductions in blood oxygen level-dependent (BOLD) signals (a proxy of local brain activity) in the dorsomedial prefrontal cortex in response to HEF (vs. LEF) cues (<i>p</i> < 0.006). BE (vs. NB) participants showed greater increases in the precuneus (<i>p</i> < 0.006) and thalamic regions (<i>p</i> < 0.05 corrected) to food (vs. NF). For RYGB (vs. NT) participants, BE participants, but not NB participants, showed lower BOLD signal in the middle occipital gyrus (<i>p</i> < 0.006), whilst NB participants, but not BE participants, showed lower signal in inferior frontal gyrus (<i>p</i> < 0.006) in response to HEF (vs. LEF). Results suggest distinct neural mechanisms of RGYB in BE and may help lead to improved clinical treatments. |
| first_indexed | 2024-03-10T23:15:53Z |
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| id | doaj.art-ecbb37ed539a480ebdf2397e09f0aa9d |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T23:15:53Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-ecbb37ed539a480ebdf2397e09f0aa9d2023-11-19T08:39:26ZengMDPI AGNutrients2072-66432023-08-011517380810.3390/nu15173808Binge Eating (BE) and Obesity: Brain Activity and Psychological Measures before and after Roux-En-Y Gastric Bypass (RYGB)Shaunte Baboumian0Lauren Puma1Charles Swencionis2Nerys M. Astbury3Jennifer Ho4Spiro P. Pantazatos5Allan Geliebter6Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Mount Sinai Morningside, 1111 Amsterdam Ave, New York, NY 10025, USADepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, Mount Sinai Morningside, 1111 Amsterdam Ave, New York, NY 10025, USAFerkauf Graduate School of Psychology, Yeshiva University, 500 West 185th Street, New York, NY 10033, USANuffield Department of Primary Care Health Sciences, Medical Sciences Division, University of Oxford, Oxford OX2 6GG, UKDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, Mount Sinai Morningside, 1111 Amsterdam Ave, New York, NY 10025, USAMolecular Imaging and Neuropathology Division, New York State Psychiatric Institute, Department of Psychiatry, Columbia University Irving Medical Center, 1051 Riverside Dr, New York, NY 10032, USADepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, Mount Sinai Morningside, 1111 Amsterdam Ave, New York, NY 10025, USABrain activity in response to food cues following Roux-En-Y Gastric Bypass (RYGB) in binge eating (BE) or non-binge eating (NB) individuals is understudied. Here, 15 RYGB (8 BE; 7 NB) and 13 no treatment (NT) (7 BE; 6 NB) women with obesity underwent fMRI imaging while viewing high and low energy density food (HEF and LEF, respectively) and non-food (NF) visual cues. A region of interest (ROI) analysis compared BE participants to NB participants in those undergoing RYGB surgery pre-surgery and 4 months post. Results were corrected for multiple comparisons using liberal (<i>p</i> < 0.006 uncorrected) and stringent (<i>p</i> < 0.05 FDR corrected) thresholds. Four months following RYGB (vs. no treatment (NT) control), both BE and NB participants showed greater reductions in blood oxygen level-dependent (BOLD) signals (a proxy of local brain activity) in the dorsomedial prefrontal cortex in response to HEF (vs. LEF) cues (<i>p</i> < 0.006). BE (vs. NB) participants showed greater increases in the precuneus (<i>p</i> < 0.006) and thalamic regions (<i>p</i> < 0.05 corrected) to food (vs. NF). For RYGB (vs. NT) participants, BE participants, but not NB participants, showed lower BOLD signal in the middle occipital gyrus (<i>p</i> < 0.006), whilst NB participants, but not BE participants, showed lower signal in inferior frontal gyrus (<i>p</i> < 0.006) in response to HEF (vs. LEF). Results suggest distinct neural mechanisms of RGYB in BE and may help lead to improved clinical treatments.https://www.mdpi.com/2072-6643/15/17/3808fMRIbariatric surgeryregion of interest (ROI) analysisbinge eatingindividuals with obesity |
| spellingShingle | Shaunte Baboumian Lauren Puma Charles Swencionis Nerys M. Astbury Jennifer Ho Spiro P. Pantazatos Allan Geliebter Binge Eating (BE) and Obesity: Brain Activity and Psychological Measures before and after Roux-En-Y Gastric Bypass (RYGB) Nutrients fMRI bariatric surgery region of interest (ROI) analysis binge eating individuals with obesity |
| title | Binge Eating (BE) and Obesity: Brain Activity and Psychological Measures before and after Roux-En-Y Gastric Bypass (RYGB) |
| title_full | Binge Eating (BE) and Obesity: Brain Activity and Psychological Measures before and after Roux-En-Y Gastric Bypass (RYGB) |
| title_fullStr | Binge Eating (BE) and Obesity: Brain Activity and Psychological Measures before and after Roux-En-Y Gastric Bypass (RYGB) |
| title_full_unstemmed | Binge Eating (BE) and Obesity: Brain Activity and Psychological Measures before and after Roux-En-Y Gastric Bypass (RYGB) |
| title_short | Binge Eating (BE) and Obesity: Brain Activity and Psychological Measures before and after Roux-En-Y Gastric Bypass (RYGB) |
| title_sort | binge eating be and obesity brain activity and psychological measures before and after roux en y gastric bypass rygb |
| topic | fMRI bariatric surgery region of interest (ROI) analysis binge eating individuals with obesity |
| url | https://www.mdpi.com/2072-6643/15/17/3808 |
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