Scientific Opinion on the safety and efficacy of aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups (chemical group 20) when used as flavourings for all animal species

Chemical group 20 consists of aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups, of which 31 are currently authorised for use as flavours in food. The FEEDAP Panel was unable to perform an assessment of six comp...

Full description

Bibliographic Details
Main Author: EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
Format: Article
Language:English
Published: Wiley 2013-05-01
Series:EFSA Journal
Subjects:
Online Access:http://www.efsa.europa.eu/en/efsajournal/doc/3208.pdf
_version_ 1818617024345014272
author EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
author_facet EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
author_sort EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
collection DOAJ
description Chemical group 20 consists of aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups, of which 31 are currently authorised for use as flavours in food. The FEEDAP Panel was unable to perform an assessment of six compounds (methanethiol, methyl propyl disulphide, dipropyl trisulphide, 3-mercaptobutan-2-one, 3-(methylthio)butanal and 3-methyl-1,2,4-trithiane) because of issues related to the purity of the compounds. The FEEDAP Panel concludes that the following 25 compounds are safe for the target species at the proposed maximum dose level (0.05 mg/kg complete feed): 3-(methylthio)propionaldehyde, methyl 3-(methylthio)propionate, allylthiol, dimethyl sulphide, dibutyl sulphide, diallyl disulphide, diallyl trisulphide, dimethyl trisulphide, dipropyl disulphide, allyl isothiocyanate, dimethyl disulphide, 2-methylbenzene-1-thiol, S-methyl butanethioate, allyl methyl disulphide, 3-(methylthio)propan-1-ol, 3-(methylthio)hexan-1-ol, 1-propane-1-thiol, diallyl sulphide, 2,4-dithiapentane, 2-methyl-2-(methyldithio)propanal, 2-methylpropane-1-thiol, methylsulfinylmethane, propane-2-thiol, 3,5-dimethyl-1,2,4-trithiolane and 2-methyl-4-propyl-1,3-oxathiane. No safety concern for the consumer would arise from the use of these 25 compounds of CG 20 up to the highest safe level in feedingstuffs for all animal species, with the exception of allyl isothiocyanate. Although additional exposure to this substance through its low use level in animal feeds would not substantially increase consumer exposure, the FEEDAP Panel notes that the estimated exposure of consumers is already higher than the acceptable daily intake (ADI). All compounds should be considered irritant to skin, eyes and respiratory tract and as skin sensitisers. The proposed concentration of 0.05 mg flavour/kg feed is not expected to cause detrimental effects to the environment, except for 2-methylpropane-1-thiol, for which 0.04 mg/kg is expected to be safe. Since all 25 compounds are used in food as flavourings and their function is essentially the same as that in food, no further demonstration of efficacy is necessary.
first_indexed 2024-12-16T16:59:07Z
format Article
id doaj.art-ecbddf65415e48b7a0c299edfd4a7472
institution Directory Open Access Journal
issn 1831-4732
language English
last_indexed 2024-12-16T16:59:07Z
publishDate 2013-05-01
publisher Wiley
record_format Article
series EFSA Journal
spelling doaj.art-ecbddf65415e48b7a0c299edfd4a74722022-12-21T22:23:48ZengWileyEFSA Journal1831-47322013-05-0111510.2903/j.efsa.2013.3208Scientific Opinion on the safety and efficacy of aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups (chemical group 20) when used as flavourings for all animal speciesEFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Chemical group 20 consists of aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups, of which 31 are currently authorised for use as flavours in food. The FEEDAP Panel was unable to perform an assessment of six compounds (methanethiol, methyl propyl disulphide, dipropyl trisulphide, 3-mercaptobutan-2-one, 3-(methylthio)butanal and 3-methyl-1,2,4-trithiane) because of issues related to the purity of the compounds. The FEEDAP Panel concludes that the following 25 compounds are safe for the target species at the proposed maximum dose level (0.05 mg/kg complete feed): 3-(methylthio)propionaldehyde, methyl 3-(methylthio)propionate, allylthiol, dimethyl sulphide, dibutyl sulphide, diallyl disulphide, diallyl trisulphide, dimethyl trisulphide, dipropyl disulphide, allyl isothiocyanate, dimethyl disulphide, 2-methylbenzene-1-thiol, S-methyl butanethioate, allyl methyl disulphide, 3-(methylthio)propan-1-ol, 3-(methylthio)hexan-1-ol, 1-propane-1-thiol, diallyl sulphide, 2,4-dithiapentane, 2-methyl-2-(methyldithio)propanal, 2-methylpropane-1-thiol, methylsulfinylmethane, propane-2-thiol, 3,5-dimethyl-1,2,4-trithiolane and 2-methyl-4-propyl-1,3-oxathiane. No safety concern for the consumer would arise from the use of these 25 compounds of CG 20 up to the highest safe level in feedingstuffs for all animal species, with the exception of allyl isothiocyanate. Although additional exposure to this substance through its low use level in animal feeds would not substantially increase consumer exposure, the FEEDAP Panel notes that the estimated exposure of consumers is already higher than the acceptable daily intake (ADI). All compounds should be considered irritant to skin, eyes and respiratory tract and as skin sensitisers. The proposed concentration of 0.05 mg flavour/kg feed is not expected to cause detrimental effects to the environment, except for 2-methylpropane-1-thiol, for which 0.04 mg/kg is expected to be safe. Since all 25 compounds are used in food as flavourings and their function is essentially the same as that in food, no further demonstration of efficacy is necessary.http://www.efsa.europa.eu/en/efsajournal/doc/3208.pdfSensory additivesflavouringsaliphatic and aromatic mono- and di-thiols and mono-di-tri- and polysulphides with or without additional oxygenated functional groupschemical group 20
spellingShingle EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
Scientific Opinion on the safety and efficacy of aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups (chemical group 20) when used as flavourings for all animal species
EFSA Journal
Sensory additives
flavourings
aliphatic and aromatic mono- and di-thiols and mono-
di-
tri- and polysulphides with or without additional oxygenated functional groups
chemical group 20
title Scientific Opinion on the safety and efficacy of aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups (chemical group 20) when used as flavourings for all animal species
title_full Scientific Opinion on the safety and efficacy of aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups (chemical group 20) when used as flavourings for all animal species
title_fullStr Scientific Opinion on the safety and efficacy of aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups (chemical group 20) when used as flavourings for all animal species
title_full_unstemmed Scientific Opinion on the safety and efficacy of aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups (chemical group 20) when used as flavourings for all animal species
title_short Scientific Opinion on the safety and efficacy of aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups (chemical group 20) when used as flavourings for all animal species
title_sort scientific opinion on the safety and efficacy of aliphatic and aromatic mono and di thiols and mono di tri and polysulphides with or without additional oxygenated functional groups chemical group 20 when used as flavourings for all animal species
topic Sensory additives
flavourings
aliphatic and aromatic mono- and di-thiols and mono-
di-
tri- and polysulphides with or without additional oxygenated functional groups
chemical group 20
url http://www.efsa.europa.eu/en/efsajournal/doc/3208.pdf
work_keys_str_mv AT efsapanelonadditivesandproductsorsubstancesusedinanimalfeedfeedap scientificopiniononthesafetyandefficacyofaliphaticandaromaticmonoanddithiolsandmonoditriandpolysulphideswithorwithoutadditionaloxygenatedfunctionalgroupschemicalgroup20whenusedasflavouringsforallanimalspecies