Effects of Nattokinase on Whole Blood Viscosity and Mortality
Objective: Nattokinase is a serin protease having potent fibrinolytic effect derived from fermentation of boiled soy bean by the use of Basillus Subtilis Natto. The aim of this experimental study is to investigate the effects of intragastric Nattokinase (6 mg/day) administration for 7 days prior to...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2011-12-01
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| Series: | Türk Yoğun Bakim Derneği Dergisi |
| Subjects: | |
| Online Access: | http://www.yogunbakimderg.com/article_2627/Effects-Of-Nattokinase-On-Whole-Blood-Viscosity-And-Mortality |
| _version_ | 1797909516547784704 |
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| author | Melike Cengiz Pınar Karadamar Murat Yılmaz Nesil Coşkunfırat Atilla Ramazanoğlu Sabahat Özdem Oğuz Kerim Başkurt Herbert J Meiselman |
| author_facet | Melike Cengiz Pınar Karadamar Murat Yılmaz Nesil Coşkunfırat Atilla Ramazanoğlu Sabahat Özdem Oğuz Kerim Başkurt Herbert J Meiselman |
| author_sort | Melike Cengiz |
| collection | DOAJ |
| description | Objective: Nattokinase is a serin protease having potent fibrinolytic effect derived from fermentation of boiled soy bean by the use of Basillus Subtilis Natto. The aim of this experimental study is to investigate the effects of intragastric Nattokinase (6 mg/day) administration for 7 days prior to formation of sepsis on plasma fibrinogen levels, whole blood viscosity and mortality in rats.
Materials and Methods: Intraabdominal sepsis were performed by cecal ligation and puncture in rats supplemented with nattokinase or olive oil for 7 days prior to sepsis formation. Plasma fibrinogen, whole blood viscosity analysis and survival analysis was performed after intraabdominal sepsis formation.
Results: Mean blood viscosity of rats was lower in Nattokinase and cecal ligation group at lowest shear rate (p<0.05). However, the differences between groups were not significant at higher shear rates. No difference was found in survival rates and survival times of Nattokinase and cecal ligation and cecal ligation and puncture groups.
Conclusion: Our results were unable to show the effects of intragastric nattokinase supplementation prior to sepsis on plasma fibrinogen levels or whole blood viscosity, except low shear rate. Nattokinase did not altered survival in septic rats. (Journal of the Turkish Society Intensive Care 2011; 9: 85-9) |
| first_indexed | 2024-04-10T11:09:36Z |
| format | Article |
| id | doaj.art-ecbe2d50332e4c608b78839b82df7a3b |
| institution | Directory Open Access Journal |
| issn | 2146-6416 2147-267X |
| language | English |
| last_indexed | 2024-04-10T11:09:36Z |
| publishDate | 2011-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Yoğun Bakim Derneği Dergisi |
| spelling | doaj.art-ecbe2d50332e4c608b78839b82df7a3b2023-02-15T16:19:14ZengGalenos YayineviTürk Yoğun Bakim Derneği Dergisi2146-64162147-267X2011-12-0193858910.4274/tybdd.09.16Effects of Nattokinase on Whole Blood Viscosity and MortalityMelike Cengiz0Pınar Karadamar1Murat Yılmaz2Nesil Coşkunfırat3Atilla Ramazanoğlu4Sabahat Özdem5Oğuz Kerim Başkurt6Herbert J Meiselman7Akdeniz Üniversitesi Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Antalya, TürkiyeAkdeniz Üniversitesi Tıp Fakültesi, Fizyoloji Anabilim Dalı, Antalya, TürkiyeAkdeniz Üniversitesi Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Antalya, TürkiyeAkdeniz Üniversitesi Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Antalya, TürkiyeAkdeniz Üniversitesi Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Antalya, TürkiyeAkdeniz Üniversitesi Tıp Fakültesi, Biyokimya Anabilim Dalı, Antalya, TürkiyeAkdeniz Üniversitesi Tıp Fakültesi, Fizyoloji Anabilim Dalı, Antalya, Türkiyeeck School of Medicine, Fizyoloji ve Biyofizik Departmanı, Los Angeles, ABDObjective: Nattokinase is a serin protease having potent fibrinolytic effect derived from fermentation of boiled soy bean by the use of Basillus Subtilis Natto. The aim of this experimental study is to investigate the effects of intragastric Nattokinase (6 mg/day) administration for 7 days prior to formation of sepsis on plasma fibrinogen levels, whole blood viscosity and mortality in rats. Materials and Methods: Intraabdominal sepsis were performed by cecal ligation and puncture in rats supplemented with nattokinase or olive oil for 7 days prior to sepsis formation. Plasma fibrinogen, whole blood viscosity analysis and survival analysis was performed after intraabdominal sepsis formation. Results: Mean blood viscosity of rats was lower in Nattokinase and cecal ligation group at lowest shear rate (p<0.05). However, the differences between groups were not significant at higher shear rates. No difference was found in survival rates and survival times of Nattokinase and cecal ligation and cecal ligation and puncture groups. Conclusion: Our results were unable to show the effects of intragastric nattokinase supplementation prior to sepsis on plasma fibrinogen levels or whole blood viscosity, except low shear rate. Nattokinase did not altered survival in septic rats. (Journal of the Turkish Society Intensive Care 2011; 9: 85-9)http://www.yogunbakimderg.com/article_2627/Effects-Of-Nattokinase-On-Whole-Blood-Viscosity-And-MortalityNattokinasesepsisfibrinogenviscosity |
| spellingShingle | Melike Cengiz Pınar Karadamar Murat Yılmaz Nesil Coşkunfırat Atilla Ramazanoğlu Sabahat Özdem Oğuz Kerim Başkurt Herbert J Meiselman Effects of Nattokinase on Whole Blood Viscosity and Mortality Türk Yoğun Bakim Derneği Dergisi Nattokinase sepsis fibrinogen viscosity |
| title | Effects of Nattokinase on Whole Blood Viscosity and Mortality |
| title_full | Effects of Nattokinase on Whole Blood Viscosity and Mortality |
| title_fullStr | Effects of Nattokinase on Whole Blood Viscosity and Mortality |
| title_full_unstemmed | Effects of Nattokinase on Whole Blood Viscosity and Mortality |
| title_short | Effects of Nattokinase on Whole Blood Viscosity and Mortality |
| title_sort | effects of nattokinase on whole blood viscosity and mortality |
| topic | Nattokinase sepsis fibrinogen viscosity |
| url | http://www.yogunbakimderg.com/article_2627/Effects-Of-Nattokinase-On-Whole-Blood-Viscosity-And-Mortality |
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