Dosimetric Evaluation of the Inter-Fraction Motion of Organs at Risk in SBRT for Nodal Oligometastatic Prostate Cancer
In this paper, we aim to evaluate the entity of inter-fraction organ motion and deformation in stereotactic body radiotherapy (SBRT) treatments for nodal oligometastatic prostate cancer (PCa). Thirty-three patients with lymph nodes showing oligometastatic PCa treated with SBRT were included. Organs...
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MDPI AG
2022-10-01
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| author | Francesco La Fauci Matteo Augugliaro Giovanni Carlo Mazzola Stefania Comi Matteo Pepa Mattia Zaffaroni Maria Giulia Vincini Giulia Corrao Francesco Alessandro Mistretta Stefano Luzzago Cristiana Fodor Gennaro Musi Salvatore Gallo Giuseppe Petralia Ottavio De Cobelli Roberto Orecchia Federica Cattani Giulia Marvaso Barbara Alicja Jereczek-Fossa |
| author_facet | Francesco La Fauci Matteo Augugliaro Giovanni Carlo Mazzola Stefania Comi Matteo Pepa Mattia Zaffaroni Maria Giulia Vincini Giulia Corrao Francesco Alessandro Mistretta Stefano Luzzago Cristiana Fodor Gennaro Musi Salvatore Gallo Giuseppe Petralia Ottavio De Cobelli Roberto Orecchia Federica Cattani Giulia Marvaso Barbara Alicja Jereczek-Fossa |
| author_sort | Francesco La Fauci |
| collection | DOAJ |
| description | In this paper, we aim to evaluate the entity of inter-fraction organ motion and deformation in stereotactic body radiotherapy (SBRT) treatments for nodal oligometastatic prostate cancer (PCa). Thirty-three patients with lymph nodes showing oligometastatic PCa treated with SBRT were included. Organs at risk (OARs) were delineated using both simulation computer tomography (s-CT) and daily cone beam CTs (CBCTs) using the Raystation planning system. For each OAR, the union volume (UV) between all the CBCTs and s-CT was computed. An expanded volume (EV) of the s-CT OARs was applied using six different margins (3, 5, 8, 10, 15, and 20 mm). A percentage volume (V%) was computed to assess the intersection between each EV and UV. The OAR deformation and motion were further evaluated using the dice similarity coefficient (DSC) and mean distance to agreement (Mean_DA). The percentage maximum dose variations for all the OARs were estimated. A recalculation with higher dose prescriptions was performed by prescribing 36 Gy/3 fx, as well as 45 Gy/3 fx. The cauda showed the highest matching (DSC = 0.72; Mean_DA = 0.14 cm), and the colon showed the lowest one (DSC = 0.37; Mean_DA = 0.44 cm). The minimum margin, which ensured a V% > 95%, was 3 mm (97.5%) for the cauda and 15 mm (96.6%) for the colon. All the OARs reached the compliance of the constraints in each session. Regarding 36 Gy-plans, the ileum punctual compliance Dmax failed in 58.8% of patients, and it failed in 70.6% of the patients for the ileum, 7.14% for the colon, and 12.5% for the bladder in the case of 45 Gy-plans. This study is an ancillary study of the RADIOSA clinical trial (AIRC IG-22159) and can be used as a benchmark for dose escalation. |
| first_indexed | 2024-03-09T19:18:36Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-09T19:18:36Z |
| publishDate | 2022-10-01 |
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| series | Applied Sciences |
| spelling | doaj.art-ecc3126ce5f248e6b511b9d3a71362162023-11-24T03:35:32ZengMDPI AGApplied Sciences2076-34172022-10-0112211094910.3390/app122110949Dosimetric Evaluation of the Inter-Fraction Motion of Organs at Risk in SBRT for Nodal Oligometastatic Prostate CancerFrancesco La Fauci0Matteo Augugliaro1Giovanni Carlo Mazzola2Stefania Comi3Matteo Pepa4Mattia Zaffaroni5Maria Giulia Vincini6Giulia Corrao7Francesco Alessandro Mistretta8Stefano Luzzago9Cristiana Fodor10Gennaro Musi11Salvatore Gallo12Giuseppe Petralia13Ottavio De Cobelli14Roberto Orecchia15Federica Cattani16Giulia Marvaso17Barbara Alicja Jereczek-Fossa18Unit of Medical Physics, IEO, European Institute of Oncology IRCCS, 20141 Milan, ItalyDivision of Radiation Oncology, IEO, European Institute of Oncology IRCCS, 20141 Milan, ItalyDivision of Radiation Oncology, IEO, European Institute of Oncology IRCCS, 20141 Milan, ItalyUnit of Medical Physics, IEO, European Institute of Oncology IRCCS, 20141 Milan, ItalyDivision of Radiation Oncology, IEO, European Institute of Oncology IRCCS, 20141 Milan, ItalyDivision of Radiation Oncology, IEO, European Institute of Oncology IRCCS, 20141 Milan, ItalyDivision of Radiation Oncology, IEO, European Institute of Oncology IRCCS, 20141 Milan, ItalyDivision of Radiation Oncology, IEO, European Institute of Oncology IRCCS, 20141 Milan, ItalyDepartment of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, ItalyDepartment of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, ItalyDivision of Radiation Oncology, IEO, European Institute of Oncology IRCCS, 20141 Milan, ItalyDepartment of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, ItalyDepartment of Physics “Aldo Pontremoli”, University of Milan, 20133 Milan, ItalyDepartment of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, ItalyDepartment of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, ItalyScientific Directorate, IEO, European Institute of Oncology IRCCS, 20141 Milan, ItalyUnit of Medical Physics, IEO, European Institute of Oncology IRCCS, 20141 Milan, ItalyDivision of Radiation Oncology, IEO, European Institute of Oncology IRCCS, 20141 Milan, ItalyDivision of Radiation Oncology, IEO, European Institute of Oncology IRCCS, 20141 Milan, ItalyIn this paper, we aim to evaluate the entity of inter-fraction organ motion and deformation in stereotactic body radiotherapy (SBRT) treatments for nodal oligometastatic prostate cancer (PCa). Thirty-three patients with lymph nodes showing oligometastatic PCa treated with SBRT were included. Organs at risk (OARs) were delineated using both simulation computer tomography (s-CT) and daily cone beam CTs (CBCTs) using the Raystation planning system. For each OAR, the union volume (UV) between all the CBCTs and s-CT was computed. An expanded volume (EV) of the s-CT OARs was applied using six different margins (3, 5, 8, 10, 15, and 20 mm). A percentage volume (V%) was computed to assess the intersection between each EV and UV. The OAR deformation and motion were further evaluated using the dice similarity coefficient (DSC) and mean distance to agreement (Mean_DA). The percentage maximum dose variations for all the OARs were estimated. A recalculation with higher dose prescriptions was performed by prescribing 36 Gy/3 fx, as well as 45 Gy/3 fx. The cauda showed the highest matching (DSC = 0.72; Mean_DA = 0.14 cm), and the colon showed the lowest one (DSC = 0.37; Mean_DA = 0.44 cm). The minimum margin, which ensured a V% > 95%, was 3 mm (97.5%) for the cauda and 15 mm (96.6%) for the colon. All the OARs reached the compliance of the constraints in each session. Regarding 36 Gy-plans, the ileum punctual compliance Dmax failed in 58.8% of patients, and it failed in 70.6% of the patients for the ileum, 7.14% for the colon, and 12.5% for the bladder in the case of 45 Gy-plans. This study is an ancillary study of the RADIOSA clinical trial (AIRC IG-22159) and can be used as a benchmark for dose escalation.https://www.mdpi.com/2076-3417/12/21/10949oligometastatic prostate cancerstereotactic body radiotherapycomputed tomographyplanninginter fractionorgan motion |
| spellingShingle | Francesco La Fauci Matteo Augugliaro Giovanni Carlo Mazzola Stefania Comi Matteo Pepa Mattia Zaffaroni Maria Giulia Vincini Giulia Corrao Francesco Alessandro Mistretta Stefano Luzzago Cristiana Fodor Gennaro Musi Salvatore Gallo Giuseppe Petralia Ottavio De Cobelli Roberto Orecchia Federica Cattani Giulia Marvaso Barbara Alicja Jereczek-Fossa Dosimetric Evaluation of the Inter-Fraction Motion of Organs at Risk in SBRT for Nodal Oligometastatic Prostate Cancer Applied Sciences oligometastatic prostate cancer stereotactic body radiotherapy computed tomography planning inter fraction organ motion |
| title | Dosimetric Evaluation of the Inter-Fraction Motion of Organs at Risk in SBRT for Nodal Oligometastatic Prostate Cancer |
| title_full | Dosimetric Evaluation of the Inter-Fraction Motion of Organs at Risk in SBRT for Nodal Oligometastatic Prostate Cancer |
| title_fullStr | Dosimetric Evaluation of the Inter-Fraction Motion of Organs at Risk in SBRT for Nodal Oligometastatic Prostate Cancer |
| title_full_unstemmed | Dosimetric Evaluation of the Inter-Fraction Motion of Organs at Risk in SBRT for Nodal Oligometastatic Prostate Cancer |
| title_short | Dosimetric Evaluation of the Inter-Fraction Motion of Organs at Risk in SBRT for Nodal Oligometastatic Prostate Cancer |
| title_sort | dosimetric evaluation of the inter fraction motion of organs at risk in sbrt for nodal oligometastatic prostate cancer |
| topic | oligometastatic prostate cancer stereotactic body radiotherapy computed tomography planning inter fraction organ motion |
| url | https://www.mdpi.com/2076-3417/12/21/10949 |
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