Evaluation of the Antioxidant, Cytoprotective and Antityrosinase Effects of <i>Schisandra chinensis</i> Extracts and Their Applicability in Skin Care Product
Plant extracts have been widely used for skin care for many centuries, and nowadays, they are commonly applied for the development and enrichment of new cosmetic preparations. The present study aimed the assessment of the biological activity of aqueous <i>Schisandra chinensis</i> extract...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/24/8877 |
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| author | Martyna Zagórska-Dziok Magdalena Wójciak Aleksandra Ziemlewska Zofia Nizioł-Łukaszewska Uliana Hoian Katarzyna Klimczak Dariusz Szczepanek Ireneusz Sowa |
| author_facet | Martyna Zagórska-Dziok Magdalena Wójciak Aleksandra Ziemlewska Zofia Nizioł-Łukaszewska Uliana Hoian Katarzyna Klimczak Dariusz Szczepanek Ireneusz Sowa |
| author_sort | Martyna Zagórska-Dziok |
| collection | DOAJ |
| description | Plant extracts have been widely used for skin care for many centuries, and nowadays, they are commonly applied for the development and enrichment of new cosmetic preparations. The present study aimed the assessment of the biological activity of aqueous <i>Schisandra chinensis</i> extracts as a potential ingredient of skin care products. The aspects studied involved the ability to neutralize free radicals, impact on viability and metabolism of keratinocytes, as well as tyrosinase inhibitory potential. Our study showed that aqueous <i>S. chinensis</i> extracts have a positive effect on keratinocyte growth and have high antioxidant potential and strong tyrosinase inhibitory activity. UPLC-MS analysis revealed that three groups of phenolic compounds were predominant in the analyzed extract, including lignans, phenolic acids and flavonoids and protocatechiuc and p-coumaryl quinic acids were predominant. Moreover, microwave-assisted extraction, followed by heat reflux extraction, was the most effective for extracting polyphenols. Furthermore, a prototypical natural body washes gel formulation containing the previously prepared extracts was developed. The irritation potential and viscosity were assessed for each of the formulations. The study demonstrated that the addition of these extracts to body wash gel formulations has a positive effect on their quality and may contribute to a decrease in skin irritation. In summary, <i>S. chinensis</i> aqueous extracts can be seen as an innovative ingredient useful in the cosmetic and pharmaceutical industry. |
| first_indexed | 2024-03-09T16:02:45Z |
| format | Article |
| id | doaj.art-ecc68823c220473f933507da00d12465 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T16:02:45Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ecc68823c220473f933507da00d124652023-11-24T16:58:57ZengMDPI AGMolecules1420-30492022-12-012724887710.3390/molecules27248877Evaluation of the Antioxidant, Cytoprotective and Antityrosinase Effects of <i>Schisandra chinensis</i> Extracts and Their Applicability in Skin Care ProductMartyna Zagórska-Dziok0Magdalena Wójciak1Aleksandra Ziemlewska2Zofia Nizioł-Łukaszewska3Uliana Hoian4Katarzyna Klimczak5Dariusz Szczepanek6Ireneusz Sowa7Department of Technology of Cosmetic and Pharmaceutical Products, Medical College, University of Information Technology and Management in Rzeszow, Kielnarowa 386a, 36-020 Tyczyn, PolandDepartment of Analytical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, PolandDepartment of Technology of Cosmetic and Pharmaceutical Products, Medical College, University of Information Technology and Management in Rzeszow, Kielnarowa 386a, 36-020 Tyczyn, PolandDepartment of Technology of Cosmetic and Pharmaceutical Products, Medical College, University of Information Technology and Management in Rzeszow, Kielnarowa 386a, 36-020 Tyczyn, PolandDepartment of Technology of Cosmetic and Pharmaceutical Products, Medical College, University of Information Technology and Management in Rzeszow, Kielnarowa 386a, 36-020 Tyczyn, PolandDepartment of Technology of Cosmetic and Pharmaceutical Products, Medical College, University of Information Technology and Management in Rzeszow, Kielnarowa 386a, 36-020 Tyczyn, PolandChair and Department of Neurosurgery and Paediatric Neurosurgery, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Analytical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, PolandPlant extracts have been widely used for skin care for many centuries, and nowadays, they are commonly applied for the development and enrichment of new cosmetic preparations. The present study aimed the assessment of the biological activity of aqueous <i>Schisandra chinensis</i> extracts as a potential ingredient of skin care products. The aspects studied involved the ability to neutralize free radicals, impact on viability and metabolism of keratinocytes, as well as tyrosinase inhibitory potential. Our study showed that aqueous <i>S. chinensis</i> extracts have a positive effect on keratinocyte growth and have high antioxidant potential and strong tyrosinase inhibitory activity. UPLC-MS analysis revealed that three groups of phenolic compounds were predominant in the analyzed extract, including lignans, phenolic acids and flavonoids and protocatechiuc and p-coumaryl quinic acids were predominant. Moreover, microwave-assisted extraction, followed by heat reflux extraction, was the most effective for extracting polyphenols. Furthermore, a prototypical natural body washes gel formulation containing the previously prepared extracts was developed. The irritation potential and viscosity were assessed for each of the formulations. The study demonstrated that the addition of these extracts to body wash gel formulations has a positive effect on their quality and may contribute to a decrease in skin irritation. In summary, <i>S. chinensis</i> aqueous extracts can be seen as an innovative ingredient useful in the cosmetic and pharmaceutical industry.https://www.mdpi.com/1420-3049/27/24/8877<i>Schisandra chinensis</i>antioxidant activityirritation potentialtyrosinase inhibitorcosmetic safety |
| spellingShingle | Martyna Zagórska-Dziok Magdalena Wójciak Aleksandra Ziemlewska Zofia Nizioł-Łukaszewska Uliana Hoian Katarzyna Klimczak Dariusz Szczepanek Ireneusz Sowa Evaluation of the Antioxidant, Cytoprotective and Antityrosinase Effects of <i>Schisandra chinensis</i> Extracts and Their Applicability in Skin Care Product Molecules <i>Schisandra chinensis</i> antioxidant activity irritation potential tyrosinase inhibitor cosmetic safety |
| title | Evaluation of the Antioxidant, Cytoprotective and Antityrosinase Effects of <i>Schisandra chinensis</i> Extracts and Their Applicability in Skin Care Product |
| title_full | Evaluation of the Antioxidant, Cytoprotective and Antityrosinase Effects of <i>Schisandra chinensis</i> Extracts and Their Applicability in Skin Care Product |
| title_fullStr | Evaluation of the Antioxidant, Cytoprotective and Antityrosinase Effects of <i>Schisandra chinensis</i> Extracts and Their Applicability in Skin Care Product |
| title_full_unstemmed | Evaluation of the Antioxidant, Cytoprotective and Antityrosinase Effects of <i>Schisandra chinensis</i> Extracts and Their Applicability in Skin Care Product |
| title_short | Evaluation of the Antioxidant, Cytoprotective and Antityrosinase Effects of <i>Schisandra chinensis</i> Extracts and Their Applicability in Skin Care Product |
| title_sort | evaluation of the antioxidant cytoprotective and antityrosinase effects of i schisandra chinensis i extracts and their applicability in skin care product |
| topic | <i>Schisandra chinensis</i> antioxidant activity irritation potential tyrosinase inhibitor cosmetic safety |
| url | https://www.mdpi.com/1420-3049/27/24/8877 |
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