CD4 and CD8 T cell responses to the M. tuberculosis Ag85B-TB10.4 promoted by adjuvanted subunit, adenovector or heterologous prime boost vaccination.

CD4 and CD8 T cell responses to the M. tuberculosis Ag85B-TB10.4 promoted by adjuvanted subunit, adenovector or heterologous prime boost vaccination.

<h4>Background</h4>Although CD4 T cells are crucial for defense against M.tb, it is still not clear whether the optimal response against M.tb in fact involves both CD4 and CD8 T cells. To test this, we used a new vaccine strategy that generated a strong balanced T cell response consistin...

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Bibliographic Details
Main Authors:	Tara Elvang, Jan P Christensen, Rolf Billeskov, Truc Thi Kim Thanh Hoang, Peter Holst, Allan Randrup Thomsen, Peter Andersen, Jes Dietrich
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2009-01-01
Series:	PLoS ONE
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19357780/pdf/?tool=EBI

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