Interaction of Diamine Oxidase with Psychostimulant Drugs for ADHD Management
Histamine intolerance occurs when there is an imbalance between histamine production and the capacity for histamine degradation. Diamine oxidase (DAO) is the main enzyme for the catabolism of ingested histamine degradation in the gastrointestinal tract and its deficiency has been linked to allergy-l...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/14/4666 |
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| author | Yaiza Tobajas Marc Alemany-Fornés Iris Samarra Jordi Romero-Giménez Maria Tintoré Antoni del Pino Núria Canela Josep M. del Bas Nàdia Ortega-Olivé Carlos de Lecea Xavier Escoté |
| author_facet | Yaiza Tobajas Marc Alemany-Fornés Iris Samarra Jordi Romero-Giménez Maria Tintoré Antoni del Pino Núria Canela Josep M. del Bas Nàdia Ortega-Olivé Carlos de Lecea Xavier Escoté |
| author_sort | Yaiza Tobajas |
| collection | DOAJ |
| description | Histamine intolerance occurs when there is an imbalance between histamine production and the capacity for histamine degradation. Diamine oxidase (DAO) is the main enzyme for the catabolism of ingested histamine degradation in the gastrointestinal tract and its deficiency has been linked to allergy-like symptoms. Psychostimulant drugs are commonly used to treat Attention Deficit Hyperactivity Disorder (ADHD), but their interaction with DAO is not well characterized. In this work, we evaluated the effects of psychostimulant drugs (methylphenidate and lisdexamfetamine) on in vitro DAO activity and in the human cell line of enterocytes (Caco-2), evaluating DAO expression (mRNA and protein) and DAO activity. Methylphenidate and lisdexamfetamine did not repress the in vitro DAO activity. In addition, in Caco-2 cells, lisdexamfetamine promoted a strong upregulation of DAO mRNA levels, whereas methylphenidate tended to induce DAO activity. To sum up, methylphenidate and lisdexamfetamine treatments do not reduce DAO activity. These findings could be useful for physicians prescribing these two drugs to ADHD patients affected by DAO deficiency. |
| first_indexed | 2024-03-11T00:58:12Z |
| format | Article |
| id | doaj.art-ecc80c329df240a8a3df8ba60f9b9c8a |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T00:58:12Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-ecc80c329df240a8a3df8ba60f9b9c8a2023-11-18T19:52:11ZengMDPI AGJournal of Clinical Medicine2077-03832023-07-011214466610.3390/jcm12144666Interaction of Diamine Oxidase with Psychostimulant Drugs for ADHD ManagementYaiza Tobajas0Marc Alemany-Fornés1Iris Samarra2Jordi Romero-Giménez3Maria Tintoré4Antoni del Pino5Núria Canela6Josep M. del Bas7Nàdia Ortega-Olivé8Carlos de Lecea9Xavier Escoté10Eurecat, Centre Tecnològic de Catalunya, Nutrition and Health, 43204 Reus, SpainDR Healthcare-AB Biotek, 08017 Barcelona, SpainCentre for Omic Sciences (COS), Joint Unit URV-EURECAT, Unique Scientific and Technical Infrastructures (ICTS), Eurecat, Centre Tecnològic de Catalunya, 43204 Reus, SpainEurecat, Centre Tecnològic de Catalunya, Nutrition and Health, 43204 Reus, SpainDR Healthcare-AB Biotek, 08017 Barcelona, SpainCentre for Omic Sciences (COS), Joint Unit URV-EURECAT, Unique Scientific and Technical Infrastructures (ICTS), Eurecat, Centre Tecnològic de Catalunya, 43204 Reus, SpainCentre for Omic Sciences (COS), Joint Unit URV-EURECAT, Unique Scientific and Technical Infrastructures (ICTS), Eurecat, Centre Tecnològic de Catalunya, 43204 Reus, SpainEurecat, Centre Tecnològic de Catalunya, Biotechnology Area, 43204 Reus, SpainEurecat, Centre Tecnològic de Catalunya, Nutrition and Health, 43204 Reus, SpainDR Healthcare-AB Biotek, 08017 Barcelona, SpainEurecat, Centre Tecnològic de Catalunya, Nutrition and Health, 43204 Reus, SpainHistamine intolerance occurs when there is an imbalance between histamine production and the capacity for histamine degradation. Diamine oxidase (DAO) is the main enzyme for the catabolism of ingested histamine degradation in the gastrointestinal tract and its deficiency has been linked to allergy-like symptoms. Psychostimulant drugs are commonly used to treat Attention Deficit Hyperactivity Disorder (ADHD), but their interaction with DAO is not well characterized. In this work, we evaluated the effects of psychostimulant drugs (methylphenidate and lisdexamfetamine) on in vitro DAO activity and in the human cell line of enterocytes (Caco-2), evaluating DAO expression (mRNA and protein) and DAO activity. Methylphenidate and lisdexamfetamine did not repress the in vitro DAO activity. In addition, in Caco-2 cells, lisdexamfetamine promoted a strong upregulation of DAO mRNA levels, whereas methylphenidate tended to induce DAO activity. To sum up, methylphenidate and lisdexamfetamine treatments do not reduce DAO activity. These findings could be useful for physicians prescribing these two drugs to ADHD patients affected by DAO deficiency.https://www.mdpi.com/2077-0383/12/14/4666ADHDDAOhistamine intolerancepsychostimulant drugs |
| spellingShingle | Yaiza Tobajas Marc Alemany-Fornés Iris Samarra Jordi Romero-Giménez Maria Tintoré Antoni del Pino Núria Canela Josep M. del Bas Nàdia Ortega-Olivé Carlos de Lecea Xavier Escoté Interaction of Diamine Oxidase with Psychostimulant Drugs for ADHD Management Journal of Clinical Medicine ADHD DAO histamine intolerance psychostimulant drugs |
| title | Interaction of Diamine Oxidase with Psychostimulant Drugs for ADHD Management |
| title_full | Interaction of Diamine Oxidase with Psychostimulant Drugs for ADHD Management |
| title_fullStr | Interaction of Diamine Oxidase with Psychostimulant Drugs for ADHD Management |
| title_full_unstemmed | Interaction of Diamine Oxidase with Psychostimulant Drugs for ADHD Management |
| title_short | Interaction of Diamine Oxidase with Psychostimulant Drugs for ADHD Management |
| title_sort | interaction of diamine oxidase with psychostimulant drugs for adhd management |
| topic | ADHD DAO histamine intolerance psychostimulant drugs |
| url | https://www.mdpi.com/2077-0383/12/14/4666 |
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