ZIKA Virus infection in pregnant women in French Guiana: More precarious-more at risk.
BACKGROUND:A recent study in French Guiana suggested that populations living in precarious neighborhoods were more at risk for Chikungunya CHIKV than those living in more privileged areas. The objective of the present study was to test the hypothesis that Zika virus (ZIKV) infection was more frequen...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-03-01
|
| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0008193 |
| _version_ | 1818579464024489984 |
|---|---|
| author | Edouard Hallet Claude Flamand Dominique Rousset Timothée Bonifay Camille Fritzell Séverine Matheus Maryvonne Dueymes Balthazar Ntab Mathieu Nacher |
| author_facet | Edouard Hallet Claude Flamand Dominique Rousset Timothée Bonifay Camille Fritzell Séverine Matheus Maryvonne Dueymes Balthazar Ntab Mathieu Nacher |
| author_sort | Edouard Hallet |
| collection | DOAJ |
| description | BACKGROUND:A recent study in French Guiana suggested that populations living in precarious neighborhoods were more at risk for Chikungunya CHIKV than those living in more privileged areas. The objective of the present study was to test the hypothesis that Zika virus (ZIKV) infection was more frequent in precarious pregnant women than in non-precarious pregnant women, as reflected by their health insurance status. METHODS:A multicentric cross-sectional study was conducted in Cayenne hospital including ZIKV pregnant women with serological or molecular proof of ZIKV during their pregnancy between January and December 2016. Health insurance information was recorded at delivery, which allowed separating women in: undocumented foreigners, precarious but with residence permit, and non-precarious. RESULTS:A total of 6654 women were included. Among them 1509 (22,7%) had confirmed ZIKV infection. Most women were precarious (2275/3439) but the proportion of precarious women was significantly greater in ZIKV-confirmed 728/906 (80.4%) than the ZIKV-negatives 1747/2533 (69.0%), p<0.0001. There were 1142 women classified as non-precarious, 1671 were precarious legal residents, and 1435 were precarious and undocumented. Precariousness and undocumented status were associated with a higher prevalence of ZIKV during pregnancy (adjusted prevalence ratio = 1.59 (95%CI = 1.29-1.97), p<0.0001), (adjusted prevalence ratio = 1.5 (95%CI = 1.2-1.8), p<0.0001), respectively. CONCLUSIONS:These results illustrate that in French Guiana ZIKV transmission disproportionately affected the socially vulnerable pregnant women, presumably because of poorer housing conditions, and lack of vector control measures in poor neighborhoods. |
| first_indexed | 2024-12-16T07:02:07Z |
| format | Article |
| id | doaj.art-ecc9488a4fd74ed68aa3577037222bcb |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-12-16T07:02:07Z |
| publishDate | 2020-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-ecc9488a4fd74ed68aa3577037222bcb2022-12-21T22:40:08ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352020-03-01143e000819310.1371/journal.pntd.0008193ZIKA Virus infection in pregnant women in French Guiana: More precarious-more at risk.Edouard HalletClaude FlamandDominique RoussetTimothée BonifayCamille FritzellSéverine MatheusMaryvonne DueymesBalthazar NtabMathieu NacherBACKGROUND:A recent study in French Guiana suggested that populations living in precarious neighborhoods were more at risk for Chikungunya CHIKV than those living in more privileged areas. The objective of the present study was to test the hypothesis that Zika virus (ZIKV) infection was more frequent in precarious pregnant women than in non-precarious pregnant women, as reflected by their health insurance status. METHODS:A multicentric cross-sectional study was conducted in Cayenne hospital including ZIKV pregnant women with serological or molecular proof of ZIKV during their pregnancy between January and December 2016. Health insurance information was recorded at delivery, which allowed separating women in: undocumented foreigners, precarious but with residence permit, and non-precarious. RESULTS:A total of 6654 women were included. Among them 1509 (22,7%) had confirmed ZIKV infection. Most women were precarious (2275/3439) but the proportion of precarious women was significantly greater in ZIKV-confirmed 728/906 (80.4%) than the ZIKV-negatives 1747/2533 (69.0%), p<0.0001. There were 1142 women classified as non-precarious, 1671 were precarious legal residents, and 1435 were precarious and undocumented. Precariousness and undocumented status were associated with a higher prevalence of ZIKV during pregnancy (adjusted prevalence ratio = 1.59 (95%CI = 1.29-1.97), p<0.0001), (adjusted prevalence ratio = 1.5 (95%CI = 1.2-1.8), p<0.0001), respectively. CONCLUSIONS:These results illustrate that in French Guiana ZIKV transmission disproportionately affected the socially vulnerable pregnant women, presumably because of poorer housing conditions, and lack of vector control measures in poor neighborhoods.https://doi.org/10.1371/journal.pntd.0008193 |
| spellingShingle | Edouard Hallet Claude Flamand Dominique Rousset Timothée Bonifay Camille Fritzell Séverine Matheus Maryvonne Dueymes Balthazar Ntab Mathieu Nacher ZIKA Virus infection in pregnant women in French Guiana: More precarious-more at risk. PLoS Neglected Tropical Diseases |
| title | ZIKA Virus infection in pregnant women in French Guiana: More precarious-more at risk. |
| title_full | ZIKA Virus infection in pregnant women in French Guiana: More precarious-more at risk. |
| title_fullStr | ZIKA Virus infection in pregnant women in French Guiana: More precarious-more at risk. |
| title_full_unstemmed | ZIKA Virus infection in pregnant women in French Guiana: More precarious-more at risk. |
| title_short | ZIKA Virus infection in pregnant women in French Guiana: More precarious-more at risk. |
| title_sort | zika virus infection in pregnant women in french guiana more precarious more at risk |
| url | https://doi.org/10.1371/journal.pntd.0008193 |
| work_keys_str_mv | AT edouardhallet zikavirusinfectioninpregnantwomeninfrenchguianamoreprecariousmoreatrisk AT claudeflamand zikavirusinfectioninpregnantwomeninfrenchguianamoreprecariousmoreatrisk AT dominiquerousset zikavirusinfectioninpregnantwomeninfrenchguianamoreprecariousmoreatrisk AT timotheebonifay zikavirusinfectioninpregnantwomeninfrenchguianamoreprecariousmoreatrisk AT camillefritzell zikavirusinfectioninpregnantwomeninfrenchguianamoreprecariousmoreatrisk AT severinematheus zikavirusinfectioninpregnantwomeninfrenchguianamoreprecariousmoreatrisk AT maryvonnedueymes zikavirusinfectioninpregnantwomeninfrenchguianamoreprecariousmoreatrisk AT balthazarntab zikavirusinfectioninpregnantwomeninfrenchguianamoreprecariousmoreatrisk AT mathieunacher zikavirusinfectioninpregnantwomeninfrenchguianamoreprecariousmoreatrisk |