EZH2/EHMT2 Histone Methyltransferases Inhibit the Transcription of DLX5 and Promote the Transformation of Myelodysplastic Syndrome to Acute Myeloid Leukemia

EZH2/EHMT2 Histone Methyltransferases Inhibit the Transcription of DLX5 and Promote the Transformation of Myelodysplastic Syndrome to Acute Myeloid Leukemia

Myelodysplastic syndrome (MDS) is characterized by clonal hematopoiesis and impaired differentiation, and may develop to acute myeloid leukemia (AML). We explored the mechanism of histone methyltransferase EZH2/EHMT2 during the transformation of MDS into AML. Expression of EZH2/EHMT2 in patients and...

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Bibliographic Details
Main Authors: Zhuanzhen Zheng, Ling Li, Guoxia Li, Yaofang Zhang, Chunxia Dong, Fanggang Ren, Wenliang Chen, Yanping Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
myelodysplastic syndromes
acute myeloid leukemia
EZH2
EHMT2
DLX5
H3K27me3
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.619795/full

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