Association of obesity susceptibility gene variants with metabolic syndrome in women
Aim. The aim of the study was a replicative analysis of the association of polymorphic variants of genes associated with obesity revealed by results of wide-genomic studies (GWAS) with the development of a cluster of metabolic syndrome risk parameters in women of Bashkir and Tatar ethnicity. The pol...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2017-09-01
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| Series: | Ожирение и метаболизм |
| Subjects: | |
| Online Access: | https://www.omet-endojournals.ru/jour/article/view/7973 |
| _version_ | 1797204639422087168 |
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| author | Olga V. Kochetova Leysan Z. Akhmadishina Gulnaz F. Korytina Artyom A. Karpov Olga E. Mustafina |
| author_facet | Olga V. Kochetova Leysan Z. Akhmadishina Gulnaz F. Korytina Artyom A. Karpov Olga E. Mustafina |
| author_sort | Olga V. Kochetova |
| collection | DOAJ |
| description | Aim. The aim of the study was a replicative analysis of the association of polymorphic variants of genes associated with obesity revealed by results of wide-genomic studies (GWAS) with the development of a cluster of metabolic syndrome risk parameters in women of Bashkir and Tatar ethnicity. The polymorphic markers of the following genes were analyzed: SEC16B, FADS1, KCTD15, MAF, MAP2K5, NEGR1, BDNF, TMEM18. Materials and methods. The study involved 243 women with metabolic syndrome and 298 women without the metabolic syndrome. Amplification of DNA fragments was performed using real-time PCR and TaqMan technique. Results. We found the association the metabolic syndrome with genetic markers of genes MAF and TMEM18 from Tatar. Protective informative marker of the metabolic syndrome among Tatar and Bashkir was the TT haplotype TMEM18 gene (rs2860323 and rs6548238) (р=0.005 and р=0.001, respectively). We identified the association marker rs2241423 MAP2K5 gene with the level of waist circumference (p=0.003) and with the level of cholesterol (p=0.014), the marker rs11084753 KCTD15 gene with glucose levels after exercise (p=0.002), the level of triglycerides (p=0.003) and HDL (p=0.0008) among Tatar women. We identified the association rs2241423 MAP2K5 gene marker to glycated hemoglobin level (p=0.002) and a marker gene rs174550 FADS1 with triglyceride levels (p=0.02) among Bashkir women. Conclusion. It can be assumed that the polymorphic variants FADS1, KCTD15, MAF, MAP2K5, TMEM18 genes are an important part of the genetic structure of predisposition to metabolic syndrome and/or to a cluster of clinical and biochemical indicators of the risk of metabolic syndrome. |
| first_indexed | 2024-03-08T09:13:45Z |
| format | Article |
| id | doaj.art-eccd04d040214c009f1e00966abbb6ee |
| institution | Directory Open Access Journal |
| issn | 2071-8713 2306-5524 |
| language | English |
| last_indexed | 2024-04-24T08:38:25Z |
| publishDate | 2017-09-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Ожирение и метаболизм |
| spelling | doaj.art-eccd04d040214c009f1e00966abbb6ee2024-04-16T16:16:11ZengEndocrinology Research CentreОжирение и метаболизм2071-87132306-55242017-09-01142334010.14341/omet2017233-407599Association of obesity susceptibility gene variants with metabolic syndrome in womenOlga V. Kochetova0Leysan Z. Akhmadishina1Gulnaz F. Korytina2Artyom A. Karpov3Olga E. Mustafina4<p>Institute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of Sciences</p><p>Institute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of Sciences</p><p>Institute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of Sciences</p><p>City Clinical Hospital №8</p><p>Institute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of Sciences</p>Aim. The aim of the study was a replicative analysis of the association of polymorphic variants of genes associated with obesity revealed by results of wide-genomic studies (GWAS) with the development of a cluster of metabolic syndrome risk parameters in women of Bashkir and Tatar ethnicity. The polymorphic markers of the following genes were analyzed: SEC16B, FADS1, KCTD15, MAF, MAP2K5, NEGR1, BDNF, TMEM18. Materials and methods. The study involved 243 women with metabolic syndrome and 298 women without the metabolic syndrome. Amplification of DNA fragments was performed using real-time PCR and TaqMan technique. Results. We found the association the metabolic syndrome with genetic markers of genes MAF and TMEM18 from Tatar. Protective informative marker of the metabolic syndrome among Tatar and Bashkir was the TT haplotype TMEM18 gene (rs2860323 and rs6548238) (р=0.005 and р=0.001, respectively). We identified the association marker rs2241423 MAP2K5 gene with the level of waist circumference (p=0.003) and with the level of cholesterol (p=0.014), the marker rs11084753 KCTD15 gene with glucose levels after exercise (p=0.002), the level of triglycerides (p=0.003) and HDL (p=0.0008) among Tatar women. We identified the association rs2241423 MAP2K5 gene marker to glycated hemoglobin level (p=0.002) and a marker gene rs174550 FADS1 with triglyceride levels (p=0.02) among Bashkir women. Conclusion. It can be assumed that the polymorphic variants FADS1, KCTD15, MAF, MAP2K5, TMEM18 genes are an important part of the genetic structure of predisposition to metabolic syndrome and/or to a cluster of clinical and biochemical indicators of the risk of metabolic syndrome.https://www.omet-endojournals.ru/jour/article/view/7973genetic markerassociationwomenlevel of glucoseinsulin |
| spellingShingle | Olga V. Kochetova Leysan Z. Akhmadishina Gulnaz F. Korytina Artyom A. Karpov Olga E. Mustafina Association of obesity susceptibility gene variants with metabolic syndrome in women Ожирение и метаболизм genetic marker association women level of glucose insulin |
| title | Association of obesity susceptibility gene variants with metabolic syndrome in women |
| title_full | Association of obesity susceptibility gene variants with metabolic syndrome in women |
| title_fullStr | Association of obesity susceptibility gene variants with metabolic syndrome in women |
| title_full_unstemmed | Association of obesity susceptibility gene variants with metabolic syndrome in women |
| title_short | Association of obesity susceptibility gene variants with metabolic syndrome in women |
| title_sort | association of obesity susceptibility gene variants with metabolic syndrome in women |
| topic | genetic marker association women level of glucose insulin |
| url | https://www.omet-endojournals.ru/jour/article/view/7973 |
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