Multimodality imaging differentiation of pancreatic neuroendocrine tumors and solid pseudopapillary tumors with a nomogram model: A large single-center study
BackgroundPancreatic neuroendocrine tumors (pNETs) and solid pseudopapillary tumors (SPTs) are two of the most common pancreatic neoplasms with different treatment procedures. However, the broad heterogeneity of pNETs and SPTs in clinical manifestations and radiological features often confuse the pr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.970178/full |
| _version_ | 1798028237577650176 |
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| author | Hai-Feng Hu Hai-Feng Hu Hai-Feng Hu Hai-Feng Hu Hai-Feng Hu Zheng Li Zheng Li Zheng Li Zheng Li Zheng Li Ke Chen Meng-Qi Liu Meng-Qi Liu Meng-Qi Liu Meng-Qi Liu Meng-Qi Liu Zeng Ye Zeng Ye Zeng Ye Zeng Ye Zeng Ye Xue-min Chen Yue Zhang Xian-Jun Yu Xian-Jun Yu Xian-Jun Yu Xian-Jun Yu Xian-Jun Yu Xiao-Wu Xu Xiao-Wu Xu Xiao-Wu Xu Xiao-Wu Xu Xiao-Wu Xu Shun-Rong Ji Shun-Rong Ji Shun-Rong Ji Shun-Rong Ji Shun-Rong Ji |
| author_facet | Hai-Feng Hu Hai-Feng Hu Hai-Feng Hu Hai-Feng Hu Hai-Feng Hu Zheng Li Zheng Li Zheng Li Zheng Li Zheng Li Ke Chen Meng-Qi Liu Meng-Qi Liu Meng-Qi Liu Meng-Qi Liu Meng-Qi Liu Zeng Ye Zeng Ye Zeng Ye Zeng Ye Zeng Ye Xue-min Chen Yue Zhang Xian-Jun Yu Xian-Jun Yu Xian-Jun Yu Xian-Jun Yu Xian-Jun Yu Xiao-Wu Xu Xiao-Wu Xu Xiao-Wu Xu Xiao-Wu Xu Xiao-Wu Xu Shun-Rong Ji Shun-Rong Ji Shun-Rong Ji Shun-Rong Ji Shun-Rong Ji |
| author_sort | Hai-Feng Hu |
| collection | DOAJ |
| description | BackgroundPancreatic neuroendocrine tumors (pNETs) and solid pseudopapillary tumors (SPTs) are two of the most common pancreatic neoplasms with different treatment procedures. However, the broad heterogeneity of pNETs and SPTs in clinical manifestations and radiological features often confuse the presurgical discrimination in clinical practice, and the clinical and molecular differentiation of the two tumors remains elusive to date. We presume that a large and comprehensive study into the multimodality features of pNETs and SPTs is necessary for precise clinical management.MethodsWe collected and analyzed the clinicopathological information and multimodality features of nonfunctional pNET and SPT patients, for a total of 631 cases from 2006 to 2021. Univariate analysis of imaging features, including contrast-enhanced computed tomography (CT), magnetic resonance imaging, endoscopic ultrasound (EUS) and nuclear medicine imaging, and clinical characteristics was performed, and CT features and clinical information were integrated to establish a nomogram model.ResultsWe recruited 354 nonfunctional pNET and 277 SPT patients in our cohort. Regarding demographic information, pNET patients had a lower female percentage (55.4% vs. 72.9%), smaller tumor size (2.8 vs. 4.8 cm), and older age (53.4 vs. 35.3 years). In CT imaging and EUS, pNETs tended to appear as solid and homogenous lesions with strong enhancement intensity. Multifocal lesions, duct dilation, and lymph node (LN) enlargement were more likely to be observed in pNETs, while calcification was more common in SPT lesions. On positron emission tomography (PET)/CT, pNETs exhibited significant sensitivity to somatostatin receptor scintigraphy (SRS), with positive rates of 81.4% and 95% on 99mTc-HYNIC-TOC and 68Ga-DOTATATE PET/CT, respectively, while SPTs were all negative on SRS. Multivariate analysis identifies tumor size, age, enhancement intensity, calcification, and LN enlargement as statistically significant variables.ConclusionsCompared to SPT patients, pNET patients exhibit an older age and smaller tumor size. CT manifestations of strong intensity, LN enlargement, and no calcification could indicate a higher possibility of pNET. Meanwhile, the similarity in the immunohistochemical profile indicates that the two tumors could potentially develop from the same origin. |
| first_indexed | 2024-04-11T19:04:40Z |
| format | Article |
| id | doaj.art-eccdaa5c98e4468da782180327b4238e |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-11T19:04:40Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-eccdaa5c98e4468da782180327b4238e2022-12-22T04:07:50ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2022-10-01910.3389/fsurg.2022.970178970178Multimodality imaging differentiation of pancreatic neuroendocrine tumors and solid pseudopapillary tumors with a nomogram model: A large single-center studyHai-Feng Hu0Hai-Feng Hu1Hai-Feng Hu2Hai-Feng Hu3Hai-Feng Hu4Zheng Li5Zheng Li6Zheng Li7Zheng Li8Zheng Li9Ke Chen10Meng-Qi Liu11Meng-Qi Liu12Meng-Qi Liu13Meng-Qi Liu14Meng-Qi Liu15Zeng Ye16Zeng Ye17Zeng Ye18Zeng Ye19Zeng Ye20Xue-min Chen21Yue Zhang22Xian-Jun Yu23Xian-Jun Yu24Xian-Jun Yu25Xian-Jun Yu26Xian-Jun Yu27Xiao-Wu Xu28Xiao-Wu Xu29Xiao-Wu Xu30Xiao-Wu Xu31Xiao-Wu Xu32Shun-Rong Ji33Shun-Rong Ji34Shun-Rong Ji35Shun-Rong Ji36Shun-Rong Ji37Center for Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaShanghai Pancreatic Cancer Institute, Shanghai, ChinaPancreatic Cancer Institute, Fudan University, Shanghai, ChinaCenter for Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaShanghai Pancreatic Cancer Institute, Shanghai, ChinaPancreatic Cancer Institute, Fudan University, Shanghai, ChinaDepartment of Endoscopy, Fudan University Shanghai Cancer Center, Shanghai, ChinaCenter for Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaShanghai Pancreatic Cancer Institute, Shanghai, ChinaPancreatic Cancer Institute, Fudan University, Shanghai, ChinaCenter for Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaShanghai Pancreatic Cancer Institute, Shanghai, ChinaPancreatic Cancer Institute, Fudan University, Shanghai, ChinaDepartment of Hepatopancreatobiliary Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaDepartment of Hepatopancreatobiliary Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaCenter for Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaShanghai Pancreatic Cancer Institute, Shanghai, ChinaPancreatic Cancer Institute, Fudan University, Shanghai, ChinaCenter for Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaShanghai Pancreatic Cancer Institute, Shanghai, ChinaPancreatic Cancer Institute, Fudan University, Shanghai, ChinaCenter for Neuroendocrine Tumors, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaShanghai Pancreatic Cancer Institute, Shanghai, ChinaPancreatic Cancer Institute, Fudan University, Shanghai, ChinaBackgroundPancreatic neuroendocrine tumors (pNETs) and solid pseudopapillary tumors (SPTs) are two of the most common pancreatic neoplasms with different treatment procedures. However, the broad heterogeneity of pNETs and SPTs in clinical manifestations and radiological features often confuse the presurgical discrimination in clinical practice, and the clinical and molecular differentiation of the two tumors remains elusive to date. We presume that a large and comprehensive study into the multimodality features of pNETs and SPTs is necessary for precise clinical management.MethodsWe collected and analyzed the clinicopathological information and multimodality features of nonfunctional pNET and SPT patients, for a total of 631 cases from 2006 to 2021. Univariate analysis of imaging features, including contrast-enhanced computed tomography (CT), magnetic resonance imaging, endoscopic ultrasound (EUS) and nuclear medicine imaging, and clinical characteristics was performed, and CT features and clinical information were integrated to establish a nomogram model.ResultsWe recruited 354 nonfunctional pNET and 277 SPT patients in our cohort. Regarding demographic information, pNET patients had a lower female percentage (55.4% vs. 72.9%), smaller tumor size (2.8 vs. 4.8 cm), and older age (53.4 vs. 35.3 years). In CT imaging and EUS, pNETs tended to appear as solid and homogenous lesions with strong enhancement intensity. Multifocal lesions, duct dilation, and lymph node (LN) enlargement were more likely to be observed in pNETs, while calcification was more common in SPT lesions. On positron emission tomography (PET)/CT, pNETs exhibited significant sensitivity to somatostatin receptor scintigraphy (SRS), with positive rates of 81.4% and 95% on 99mTc-HYNIC-TOC and 68Ga-DOTATATE PET/CT, respectively, while SPTs were all negative on SRS. Multivariate analysis identifies tumor size, age, enhancement intensity, calcification, and LN enlargement as statistically significant variables.ConclusionsCompared to SPT patients, pNET patients exhibit an older age and smaller tumor size. CT manifestations of strong intensity, LN enlargement, and no calcification could indicate a higher possibility of pNET. Meanwhile, the similarity in the immunohistochemical profile indicates that the two tumors could potentially develop from the same origin.https://www.frontiersin.org/articles/10.3389/fsurg.2022.970178/fullpancreaspancreatic neuroendocrine tumorsolid pseudopapillary tumormultimodality imagingclinical differentiation |
| spellingShingle | Hai-Feng Hu Hai-Feng Hu Hai-Feng Hu Hai-Feng Hu Hai-Feng Hu Zheng Li Zheng Li Zheng Li Zheng Li Zheng Li Ke Chen Meng-Qi Liu Meng-Qi Liu Meng-Qi Liu Meng-Qi Liu Meng-Qi Liu Zeng Ye Zeng Ye Zeng Ye Zeng Ye Zeng Ye Xue-min Chen Yue Zhang Xian-Jun Yu Xian-Jun Yu Xian-Jun Yu Xian-Jun Yu Xian-Jun Yu Xiao-Wu Xu Xiao-Wu Xu Xiao-Wu Xu Xiao-Wu Xu Xiao-Wu Xu Shun-Rong Ji Shun-Rong Ji Shun-Rong Ji Shun-Rong Ji Shun-Rong Ji Multimodality imaging differentiation of pancreatic neuroendocrine tumors and solid pseudopapillary tumors with a nomogram model: A large single-center study Frontiers in Surgery pancreas pancreatic neuroendocrine tumor solid pseudopapillary tumor multimodality imaging clinical differentiation |
| title | Multimodality imaging differentiation of pancreatic neuroendocrine tumors and solid pseudopapillary tumors with a nomogram model: A large single-center study |
| title_full | Multimodality imaging differentiation of pancreatic neuroendocrine tumors and solid pseudopapillary tumors with a nomogram model: A large single-center study |
| title_fullStr | Multimodality imaging differentiation of pancreatic neuroendocrine tumors and solid pseudopapillary tumors with a nomogram model: A large single-center study |
| title_full_unstemmed | Multimodality imaging differentiation of pancreatic neuroendocrine tumors and solid pseudopapillary tumors with a nomogram model: A large single-center study |
| title_short | Multimodality imaging differentiation of pancreatic neuroendocrine tumors and solid pseudopapillary tumors with a nomogram model: A large single-center study |
| title_sort | multimodality imaging differentiation of pancreatic neuroendocrine tumors and solid pseudopapillary tumors with a nomogram model a large single center study |
| topic | pancreas pancreatic neuroendocrine tumor solid pseudopapillary tumor multimodality imaging clinical differentiation |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.970178/full |
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