Epigenetic Regulation of Inflammatory Signaling and Inflammation-Induced Cancer
Epigenetics comprise a diverse array of reversible and dynamic modifications to the cell’s genome without implicating any DNA sequence alterations. Both the external environment surrounding the organism, as well as the internal microenvironment of cells and tissues, contribute to these epigenetic pr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.931493/full |
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| author | Shawn Ying Xuan Tan Jieqiong Zhang Jieqiong Zhang Wee-Wei Tee Wee-Wei Tee Wee-Wei Tee |
| author_facet | Shawn Ying Xuan Tan Jieqiong Zhang Jieqiong Zhang Wee-Wei Tee Wee-Wei Tee Wee-Wei Tee |
| author_sort | Shawn Ying Xuan Tan |
| collection | DOAJ |
| description | Epigenetics comprise a diverse array of reversible and dynamic modifications to the cell’s genome without implicating any DNA sequence alterations. Both the external environment surrounding the organism, as well as the internal microenvironment of cells and tissues, contribute to these epigenetic processes that play critical roles in cell fate specification and organismal development. On the other hand, dysregulation of epigenetic activities can initiate and sustain carcinogenesis, which is often augmented by inflammation. Chronic inflammation, one of the major hallmarks of cancer, stems from proinflammatory cytokines that are secreted by tumor and tumor-associated cells in the tumor microenvironment. At the same time, inflammatory signaling can establish positive and negative feedback circuits with chromatin to modulate changes in the global epigenetic landscape. In this review, we provide an in-depth discussion of the interconnected crosstalk between epigenetics and inflammation, specifically how epigenetic mechanisms at different hierarchical levels of the genome control inflammatory gene transcription, which in turn enact changes within the cell’s epigenomic profile, especially in the context of inflammation-induced cancer. |
| first_indexed | 2024-12-12T11:33:52Z |
| format | Article |
| id | doaj.art-eccde2a4f93f4bc597a3754c8a0e701b |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-12T11:33:52Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-eccde2a4f93f4bc597a3754c8a0e701b2022-12-22T00:25:43ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-06-011010.3389/fcell.2022.931493931493Epigenetic Regulation of Inflammatory Signaling and Inflammation-Induced CancerShawn Ying Xuan Tan0Jieqiong Zhang1Jieqiong Zhang2Wee-Wei Tee3Wee-Wei Tee4Wee-Wei Tee5Chromatin Dynamics and Disease Epigenetics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, SingaporeChromatin Dynamics and Disease Epigenetics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, SingaporeDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeChromatin Dynamics and Disease Epigenetics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, SingaporeDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeNUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeEpigenetics comprise a diverse array of reversible and dynamic modifications to the cell’s genome without implicating any DNA sequence alterations. Both the external environment surrounding the organism, as well as the internal microenvironment of cells and tissues, contribute to these epigenetic processes that play critical roles in cell fate specification and organismal development. On the other hand, dysregulation of epigenetic activities can initiate and sustain carcinogenesis, which is often augmented by inflammation. Chronic inflammation, one of the major hallmarks of cancer, stems from proinflammatory cytokines that are secreted by tumor and tumor-associated cells in the tumor microenvironment. At the same time, inflammatory signaling can establish positive and negative feedback circuits with chromatin to modulate changes in the global epigenetic landscape. In this review, we provide an in-depth discussion of the interconnected crosstalk between epigenetics and inflammation, specifically how epigenetic mechanisms at different hierarchical levels of the genome control inflammatory gene transcription, which in turn enact changes within the cell’s epigenomic profile, especially in the context of inflammation-induced cancer.https://www.frontiersin.org/articles/10.3389/fcell.2022.931493/fullcancerinflammationepigeneticshistone modificationshigh-order genome organizationsuper-enhancer |
| spellingShingle | Shawn Ying Xuan Tan Jieqiong Zhang Jieqiong Zhang Wee-Wei Tee Wee-Wei Tee Wee-Wei Tee Epigenetic Regulation of Inflammatory Signaling and Inflammation-Induced Cancer Frontiers in Cell and Developmental Biology cancer inflammation epigenetics histone modifications high-order genome organization super-enhancer |
| title | Epigenetic Regulation of Inflammatory Signaling and Inflammation-Induced Cancer |
| title_full | Epigenetic Regulation of Inflammatory Signaling and Inflammation-Induced Cancer |
| title_fullStr | Epigenetic Regulation of Inflammatory Signaling and Inflammation-Induced Cancer |
| title_full_unstemmed | Epigenetic Regulation of Inflammatory Signaling and Inflammation-Induced Cancer |
| title_short | Epigenetic Regulation of Inflammatory Signaling and Inflammation-Induced Cancer |
| title_sort | epigenetic regulation of inflammatory signaling and inflammation induced cancer |
| topic | cancer inflammation epigenetics histone modifications high-order genome organization super-enhancer |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.931493/full |
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