A meta-analysis of the therapeutic effect of probiotic intervention in obese or overweight adolescents
Background & aimsExisting evidence on the possible effects of probiotics on obese or overweight adolescents has not been fully established. Therefore, the aim of this study was to explore the effects of probiotic supplementation on anthropometric indices, inflammatory markers and metabolic i...
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1335810/full |
| _version_ | 1797339182036680704 |
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| author | Yuanqing Duan Lanping Wang Yan Ma Lei Ning Xinhuan Zhang |
| author_facet | Yuanqing Duan Lanping Wang Yan Ma Lei Ning Xinhuan Zhang |
| author_sort | Yuanqing Duan |
| collection | DOAJ |
| description | Background & aimsExisting evidence on the possible effects of probiotics on obese or overweight adolescents has not been fully established. Therefore, the aim of this study was to explore the effects of probiotic supplementation on anthropometric indices, inflammatory markers and metabolic indices in obese or overweight adolescents.MethodsThe literature up to March 2023 related to probiotic intervention in obese or overweight adolescents was searched and screened from multiple databases, including the CNKI(China national knowledge infrastructure), CBM(Chinese biomedical literature database), PubMed, EmBase, and Cochrane library databases. All randomized controlled trials using probiotic supplements in obese or overweight adolescents were included in this systematic review and meta-analysis.ResultsA total of 8 studies that met the inclusion criteria were included in this study. There were 201 cases in the experimental group (probiotic treatment) and 190 cases in the control group. Compared to the control group, probiotic intervention in adolescents resulted in a decrease in body mass index, fasting blood glucose and C-reactive protein with WMD(Weighted mean difference) and 95% CI of -2.53 (-4.8 to -0.26) kg/m2, -0.80 (-1.13 to -0.47) mol/L and -0.24 (-0.43 to -0.05) mg/L, respectively. No significant changes were found in weight, waist circumference, waist-to-hip ratio, insulin, Homeostatic Model Assessment of insulin resistance, interleukin 6, tumor necrosis factor alpha and so on; however, an unfavorable elevated effect in total cholesterol, triglycerides, and low-density lipoproteins was detected with WMD and 95% CI of 0.06 (0.02 to 0.09) mmol/L, 0.18 (0.14 to 0.21) mmol/L, and 0.19 (0.18 to 0.20) mmol/L, respectively.ConclusionAccording to our results, probiotic supplementation was beneficial in managing metabolic indicators such as fasting blood glucose, body mass index and inflammation-related C-reactive protein in overweight or obese adolescents. Further large scale studies are warranted to confirm present findings and to identify the effects and mechanisms to provide more precise evidence for clinical intervention.Systematic review registrationdoi: 10.37766/inplasy2024.1.0081, identifier INPLASY202410081. |
| first_indexed | 2024-03-08T09:42:15Z |
| format | Article |
| id | doaj.art-eccebecfc2144d2f8ab58a3b161e9f19 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T09:42:15Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-eccebecfc2144d2f8ab58a3b161e9f192024-01-30T04:25:08ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-01-011510.3389/fendo.2024.13358101335810A meta-analysis of the therapeutic effect of probiotic intervention in obese or overweight adolescentsYuanqing Duan0Lanping Wang1Yan Ma2Lei Ning3Xinhuan Zhang4Department of Endocrinology, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, ChinaDepartment of Operating Room, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, ChinaDepartment of Endocrinology, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, ChinaDepartment of Case Room, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, ChinaDepartment of Endocrinology, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, ChinaBackground & aimsExisting evidence on the possible effects of probiotics on obese or overweight adolescents has not been fully established. Therefore, the aim of this study was to explore the effects of probiotic supplementation on anthropometric indices, inflammatory markers and metabolic indices in obese or overweight adolescents.MethodsThe literature up to March 2023 related to probiotic intervention in obese or overweight adolescents was searched and screened from multiple databases, including the CNKI(China national knowledge infrastructure), CBM(Chinese biomedical literature database), PubMed, EmBase, and Cochrane library databases. All randomized controlled trials using probiotic supplements in obese or overweight adolescents were included in this systematic review and meta-analysis.ResultsA total of 8 studies that met the inclusion criteria were included in this study. There were 201 cases in the experimental group (probiotic treatment) and 190 cases in the control group. Compared to the control group, probiotic intervention in adolescents resulted in a decrease in body mass index, fasting blood glucose and C-reactive protein with WMD(Weighted mean difference) and 95% CI of -2.53 (-4.8 to -0.26) kg/m2, -0.80 (-1.13 to -0.47) mol/L and -0.24 (-0.43 to -0.05) mg/L, respectively. No significant changes were found in weight, waist circumference, waist-to-hip ratio, insulin, Homeostatic Model Assessment of insulin resistance, interleukin 6, tumor necrosis factor alpha and so on; however, an unfavorable elevated effect in total cholesterol, triglycerides, and low-density lipoproteins was detected with WMD and 95% CI of 0.06 (0.02 to 0.09) mmol/L, 0.18 (0.14 to 0.21) mmol/L, and 0.19 (0.18 to 0.20) mmol/L, respectively.ConclusionAccording to our results, probiotic supplementation was beneficial in managing metabolic indicators such as fasting blood glucose, body mass index and inflammation-related C-reactive protein in overweight or obese adolescents. Further large scale studies are warranted to confirm present findings and to identify the effects and mechanisms to provide more precise evidence for clinical intervention.Systematic review registrationdoi: 10.37766/inplasy2024.1.0081, identifier INPLASY202410081.https://www.frontiersin.org/articles/10.3389/fendo.2024.1335810/fullprobioticobesityoverweightadolescentmeta-analysis |
| spellingShingle | Yuanqing Duan Lanping Wang Yan Ma Lei Ning Xinhuan Zhang A meta-analysis of the therapeutic effect of probiotic intervention in obese or overweight adolescents Frontiers in Endocrinology probiotic obesity overweight adolescent meta-analysis |
| title | A meta-analysis of the therapeutic effect of probiotic intervention in obese or overweight adolescents |
| title_full | A meta-analysis of the therapeutic effect of probiotic intervention in obese or overweight adolescents |
| title_fullStr | A meta-analysis of the therapeutic effect of probiotic intervention in obese or overweight adolescents |
| title_full_unstemmed | A meta-analysis of the therapeutic effect of probiotic intervention in obese or overweight adolescents |
| title_short | A meta-analysis of the therapeutic effect of probiotic intervention in obese or overweight adolescents |
| title_sort | meta analysis of the therapeutic effect of probiotic intervention in obese or overweight adolescents |
| topic | probiotic obesity overweight adolescent meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1335810/full |
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