The Patient’s Physiological Status at the Start Determines the Success of the Inpatient Cardiovascular Rehabilitation Program
Multidisciplinary inpatient rehabilitation plays an important role in the recovery of patients with cardiovascular diseases (CVDs). Lifestyle changes, achieved by exercise, diet, weight loss and patient education programs, are the first steps to a healthier life. Advanced glycation end products (AGE...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/5/1735 |
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| author | Anna Odrovicsné-Tóth Bettina Thauerer Barbara Stritzinger Werner Kullich Andreas Salzer Martin Skoumal Bibiane Steinecker-Frohnwieser |
| author_facet | Anna Odrovicsné-Tóth Bettina Thauerer Barbara Stritzinger Werner Kullich Andreas Salzer Martin Skoumal Bibiane Steinecker-Frohnwieser |
| author_sort | Anna Odrovicsné-Tóth |
| collection | DOAJ |
| description | Multidisciplinary inpatient rehabilitation plays an important role in the recovery of patients with cardiovascular diseases (CVDs). Lifestyle changes, achieved by exercise, diet, weight loss and patient education programs, are the first steps to a healthier life. Advanced glycation end products (AGEs) and their receptor (RAGE) are known to be involved in CVDs. Clarification on whether initial AGE levels can influence the rehabilitation outcome is important. Serum samples were collected at the beginning and end of the inpatient rehabilitation stay and analyzed for parameters: lipid metabolism, glucose status, oxidative stress, inflammation and AGE/RAGE-axis. As result, a 5% increase in the soluble isoform RAGE (sRAGE) (T<sub>0</sub>: 891.82 ± 44.97 pg/mL, T<sub>1</sub>: 937.17 ± 43.29 pg/mL) accompanied by a 7% decrease in AGEs (T<sub>0</sub>: 10.93 ± 0.65 µg/mL, T<sub>1</sub>: 10.21 ± 0.61 µg/mL) was shown. Depending on the initial AGE level, a significant reduction of 12.2% of the AGE activity (quotient AGE/sRAGE) was observed. We found that almost all measured factors improved. Summarizing, CVD-specific multidisciplinary rehabilitation positively influences disease-associated parameters, and thus provides an optimal starting point for subsequent disease-modifying lifestyle changes. Considering our observations, the initial physiological situations of patients at the beginning of their rehabilitation stay seem to play a decisive role regarding the assessment of rehabilitation success. |
| first_indexed | 2024-03-11T07:21:04Z |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T07:21:04Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-eccffdc9304a467d99b9a5ea5b6632302023-11-17T07:57:37ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01125173510.3390/jcm12051735The Patient’s Physiological Status at the Start Determines the Success of the Inpatient Cardiovascular Rehabilitation ProgramAnna Odrovicsné-Tóth0Bettina Thauerer1Barbara Stritzinger2Werner Kullich3Andreas Salzer4Martin Skoumal5Bibiane Steinecker-Frohnwieser6Ludwig Boltzmann Institute for Arthritis and Rehabilitation, 5760 Saalfelden, AustriaLudwig Boltzmann Institute for Arthritis and Rehabilitation, 5760 Saalfelden, AustriaLudwig Boltzmann Institute for Arthritis and Rehabilitation, 5760 Saalfelden, AustriaLudwig Boltzmann Institute for Arthritis and Rehabilitation, 5760 Saalfelden, AustriaRehabilitation Center of the Austrian Pension Insurance Company (PVA), 5760 Saalfelden, AustriaRehabilitation Center of the Austrian Pension Insurance Company (PVA), 1021 Vienna, AustriaLudwig Boltzmann Institute for Arthritis and Rehabilitation, 5760 Saalfelden, AustriaMultidisciplinary inpatient rehabilitation plays an important role in the recovery of patients with cardiovascular diseases (CVDs). Lifestyle changes, achieved by exercise, diet, weight loss and patient education programs, are the first steps to a healthier life. Advanced glycation end products (AGEs) and their receptor (RAGE) are known to be involved in CVDs. Clarification on whether initial AGE levels can influence the rehabilitation outcome is important. Serum samples were collected at the beginning and end of the inpatient rehabilitation stay and analyzed for parameters: lipid metabolism, glucose status, oxidative stress, inflammation and AGE/RAGE-axis. As result, a 5% increase in the soluble isoform RAGE (sRAGE) (T<sub>0</sub>: 891.82 ± 44.97 pg/mL, T<sub>1</sub>: 937.17 ± 43.29 pg/mL) accompanied by a 7% decrease in AGEs (T<sub>0</sub>: 10.93 ± 0.65 µg/mL, T<sub>1</sub>: 10.21 ± 0.61 µg/mL) was shown. Depending on the initial AGE level, a significant reduction of 12.2% of the AGE activity (quotient AGE/sRAGE) was observed. We found that almost all measured factors improved. Summarizing, CVD-specific multidisciplinary rehabilitation positively influences disease-associated parameters, and thus provides an optimal starting point for subsequent disease-modifying lifestyle changes. Considering our observations, the initial physiological situations of patients at the beginning of their rehabilitation stay seem to play a decisive role regarding the assessment of rehabilitation success.https://www.mdpi.com/2077-0383/12/5/1735cardiovascular diseasesrehabilitationadvanced glycation end productsreceptor for advanced glycation end productsAGE activityCVD risk factors |
| spellingShingle | Anna Odrovicsné-Tóth Bettina Thauerer Barbara Stritzinger Werner Kullich Andreas Salzer Martin Skoumal Bibiane Steinecker-Frohnwieser The Patient’s Physiological Status at the Start Determines the Success of the Inpatient Cardiovascular Rehabilitation Program Journal of Clinical Medicine cardiovascular diseases rehabilitation advanced glycation end products receptor for advanced glycation end products AGE activity CVD risk factors |
| title | The Patient’s Physiological Status at the Start Determines the Success of the Inpatient Cardiovascular Rehabilitation Program |
| title_full | The Patient’s Physiological Status at the Start Determines the Success of the Inpatient Cardiovascular Rehabilitation Program |
| title_fullStr | The Patient’s Physiological Status at the Start Determines the Success of the Inpatient Cardiovascular Rehabilitation Program |
| title_full_unstemmed | The Patient’s Physiological Status at the Start Determines the Success of the Inpatient Cardiovascular Rehabilitation Program |
| title_short | The Patient’s Physiological Status at the Start Determines the Success of the Inpatient Cardiovascular Rehabilitation Program |
| title_sort | patient s physiological status at the start determines the success of the inpatient cardiovascular rehabilitation program |
| topic | cardiovascular diseases rehabilitation advanced glycation end products receptor for advanced glycation end products AGE activity CVD risk factors |
| url | https://www.mdpi.com/2077-0383/12/5/1735 |
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