| Summary: | The purpose of this study was to identify the chemical components in aerial parts of <i>Hypecoum erectum</i>. A new 1,3-benzodioxole derivative, identified as Hypecoumic acid (<b>1</b>), was isolated, together with the three known compounds: protopine (<b>2</b>), coptisine (<b>3</b>), and cryptopine (<b>4</b>). Their structures were identified based on extensive spectroscopic experiments, including nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectra (HR-ESI-MS), as well as comparison with those reported in the literature. Meanwhile, the in vitro antioxidative activity of all compounds was determined using a DPPH-scavenging assay, and compound 1 (IC<sub>50</sub> = 86.3 ± 0.2 μM) was shown to have moderate antioxidative activity.
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