A New 1,3-Benzodioxole Compound from <i>Hypecoum erectum</i> and Its Antioxidant Activity
The purpose of this study was to identify the chemical components in aerial parts of <i>Hypecoum erectum</i>. A new 1,3-benzodioxole derivative, identified as Hypecoumic acid (<b>1</b>), was isolated, together with the three known compounds: protopine (<b>2</b>),...
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MDPI AG
2022-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/19/6657 |
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| author | Ning Xu Wenli Bao Jiletu Xin Hua Xiao Jiaqi Yu Liang Xu |
| author_facet | Ning Xu Wenli Bao Jiletu Xin Hua Xiao Jiaqi Yu Liang Xu |
| author_sort | Ning Xu |
| collection | DOAJ |
| description | The purpose of this study was to identify the chemical components in aerial parts of <i>Hypecoum erectum</i>. A new 1,3-benzodioxole derivative, identified as Hypecoumic acid (<b>1</b>), was isolated, together with the three known compounds: protopine (<b>2</b>), coptisine (<b>3</b>), and cryptopine (<b>4</b>). Their structures were identified based on extensive spectroscopic experiments, including nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectra (HR-ESI-MS), as well as comparison with those reported in the literature. Meanwhile, the in vitro antioxidative activity of all compounds was determined using a DPPH-scavenging assay, and compound 1 (IC<sub>50</sub> = 86.3 ± 0.2 μM) was shown to have moderate antioxidative activity. |
| first_indexed | 2024-03-09T21:24:12Z |
| format | Article |
| id | doaj.art-ecd082f0284540ada5772f8f91cd366f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T21:24:12Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ecd082f0284540ada5772f8f91cd366f2023-11-23T21:15:02ZengMDPI AGMolecules1420-30492022-10-012719665710.3390/molecules27196657A New 1,3-Benzodioxole Compound from <i>Hypecoum erectum</i> and Its Antioxidant ActivityNing Xu0Wenli Bao1Jiletu Xin2Hua Xiao3Jiaqi Yu4Liang Xu5Inner Mongolia Key Laboratory of the Natural Products Chemistry and Functional Molecular Synthesis, Inner Mongolia Minzu University, Tongliao 028000, ChinaInner Mongolia Key Laboratory of the Natural Products Chemistry and Functional Molecular Synthesis, Inner Mongolia Minzu University, Tongliao 028000, ChinaInner Mongolia Key Laboratory of the Natural Products Chemistry and Functional Molecular Synthesis, Inner Mongolia Minzu University, Tongliao 028000, ChinaInner Mongolia Key Laboratory of the Natural Products Chemistry and Functional Molecular Synthesis, Inner Mongolia Minzu University, Tongliao 028000, ChinaInner Mongolia Key Laboratory of the Natural Products Chemistry and Functional Molecular Synthesis, Inner Mongolia Minzu University, Tongliao 028000, ChinaInner Mongolia Key Laboratory of the Natural Products Chemistry and Functional Molecular Synthesis, Inner Mongolia Minzu University, Tongliao 028000, ChinaThe purpose of this study was to identify the chemical components in aerial parts of <i>Hypecoum erectum</i>. A new 1,3-benzodioxole derivative, identified as Hypecoumic acid (<b>1</b>), was isolated, together with the three known compounds: protopine (<b>2</b>), coptisine (<b>3</b>), and cryptopine (<b>4</b>). Their structures were identified based on extensive spectroscopic experiments, including nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectra (HR-ESI-MS), as well as comparison with those reported in the literature. Meanwhile, the in vitro antioxidative activity of all compounds was determined using a DPPH-scavenging assay, and compound 1 (IC<sub>50</sub> = 86.3 ± 0.2 μM) was shown to have moderate antioxidative activity.https://www.mdpi.com/1420-3049/27/19/6657<i>Hypecoum erectum</i>spectral analysis1,3-benzodioxoleantioxidative activity |
| spellingShingle | Ning Xu Wenli Bao Jiletu Xin Hua Xiao Jiaqi Yu Liang Xu A New 1,3-Benzodioxole Compound from <i>Hypecoum erectum</i> and Its Antioxidant Activity Molecules <i>Hypecoum erectum</i> spectral analysis 1,3-benzodioxole antioxidative activity |
| title | A New 1,3-Benzodioxole Compound from <i>Hypecoum erectum</i> and Its Antioxidant Activity |
| title_full | A New 1,3-Benzodioxole Compound from <i>Hypecoum erectum</i> and Its Antioxidant Activity |
| title_fullStr | A New 1,3-Benzodioxole Compound from <i>Hypecoum erectum</i> and Its Antioxidant Activity |
| title_full_unstemmed | A New 1,3-Benzodioxole Compound from <i>Hypecoum erectum</i> and Its Antioxidant Activity |
| title_short | A New 1,3-Benzodioxole Compound from <i>Hypecoum erectum</i> and Its Antioxidant Activity |
| title_sort | new 1 3 benzodioxole compound from i hypecoum erectum i and its antioxidant activity |
| topic | <i>Hypecoum erectum</i> spectral analysis 1,3-benzodioxole antioxidative activity |
| url | https://www.mdpi.com/1420-3049/27/19/6657 |
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