Vitreous Substitutes from Bench to the Operating Room in a Translational Approach: Review and Future Endeavors in Vitreoretinal Surgery
Vitreous substitutes are indispensable tools in vitreoretinal surgery. The two crucial functions of these substitutes are their ability to displace intravitreal fluid from the retinal surface and to allow the retina to adhere to the retinal pigment epithelium. Today, vitreoretinal surgeons can choos...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/4/3342 |
| _version_ | 1797620572504457216 |
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| author | Filippo Confalonieri Natasha Josifovska Gerard Boix-Lemonche Ingar Stene-Johansen Ragnheidur Bragadottir Xhevat Lumi Goran Petrovski |
| author_facet | Filippo Confalonieri Natasha Josifovska Gerard Boix-Lemonche Ingar Stene-Johansen Ragnheidur Bragadottir Xhevat Lumi Goran Petrovski |
| author_sort | Filippo Confalonieri |
| collection | DOAJ |
| description | Vitreous substitutes are indispensable tools in vitreoretinal surgery. The two crucial functions of these substitutes are their ability to displace intravitreal fluid from the retinal surface and to allow the retina to adhere to the retinal pigment epithelium. Today, vitreoretinal surgeons can choose among a plethora of vitreous tamponades, and the tamponade of choice might be difficult to determine in the ever-expanding range of possibilities for a favorable outcome. The currently available vitreous substitutes have disadvantages that need to be addressed to improve the surgical outcome achievable today. Herein, the fundamental physical and chemical proprieties of all vitreous substitutes are reported, and their use and clinical applications are described alongside some surgical techniques of intra-operative manipulation. The major upcoming developments in vitreous substitutes are extensively discussed, keeping a translational perspective throughout. Conclusions on future perspectives are derived through an in-depth analysis of what is lacking today in terms of desired outcomes and biomaterials technology. |
| first_indexed | 2024-03-11T08:44:30Z |
| format | Article |
| id | doaj.art-ecd088d4739744508513c3b37c77066b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:44:30Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ecd088d4739744508513c3b37c77066b2023-11-16T20:58:39ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244334210.3390/ijms24043342Vitreous Substitutes from Bench to the Operating Room in a Translational Approach: Review and Future Endeavors in Vitreoretinal SurgeryFilippo Confalonieri0Natasha Josifovska1Gerard Boix-Lemonche2Ingar Stene-Johansen3Ragnheidur Bragadottir4Xhevat Lumi5Goran Petrovski6Department of Ophthalmology, Oslo University Hospital, Kirkeveien 166, 0450 Oslo, NorwayCenter for Eye Research and Innovative Diagnostics, Department of Ophthalmology, Institute for Clinical Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, NorwayCenter for Eye Research and Innovative Diagnostics, Department of Ophthalmology, Institute for Clinical Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, NorwayDepartment of Ophthalmology, Oslo University Hospital, Kirkeveien 166, 0450 Oslo, NorwayDepartment of Ophthalmology, Oslo University Hospital, Kirkeveien 166, 0450 Oslo, NorwayCenter for Eye Research and Innovative Diagnostics, Department of Ophthalmology, Institute for Clinical Medicine, University of Oslo, Kirkeveien 166, 0450 Oslo, NorwayDepartment of Ophthalmology, Oslo University Hospital, Kirkeveien 166, 0450 Oslo, NorwayVitreous substitutes are indispensable tools in vitreoretinal surgery. The two crucial functions of these substitutes are their ability to displace intravitreal fluid from the retinal surface and to allow the retina to adhere to the retinal pigment epithelium. Today, vitreoretinal surgeons can choose among a plethora of vitreous tamponades, and the tamponade of choice might be difficult to determine in the ever-expanding range of possibilities for a favorable outcome. The currently available vitreous substitutes have disadvantages that need to be addressed to improve the surgical outcome achievable today. Herein, the fundamental physical and chemical proprieties of all vitreous substitutes are reported, and their use and clinical applications are described alongside some surgical techniques of intra-operative manipulation. The major upcoming developments in vitreous substitutes are extensively discussed, keeping a translational perspective throughout. Conclusions on future perspectives are derived through an in-depth analysis of what is lacking today in terms of desired outcomes and biomaterials technology.https://www.mdpi.com/1422-0067/24/4/3342vitreous substitutesvitreoretinal surgeryretinal detachmentproliferative vitreoretinopathysilicone oil |
| spellingShingle | Filippo Confalonieri Natasha Josifovska Gerard Boix-Lemonche Ingar Stene-Johansen Ragnheidur Bragadottir Xhevat Lumi Goran Petrovski Vitreous Substitutes from Bench to the Operating Room in a Translational Approach: Review and Future Endeavors in Vitreoretinal Surgery International Journal of Molecular Sciences vitreous substitutes vitreoretinal surgery retinal detachment proliferative vitreoretinopathy silicone oil |
| title | Vitreous Substitutes from Bench to the Operating Room in a Translational Approach: Review and Future Endeavors in Vitreoretinal Surgery |
| title_full | Vitreous Substitutes from Bench to the Operating Room in a Translational Approach: Review and Future Endeavors in Vitreoretinal Surgery |
| title_fullStr | Vitreous Substitutes from Bench to the Operating Room in a Translational Approach: Review and Future Endeavors in Vitreoretinal Surgery |
| title_full_unstemmed | Vitreous Substitutes from Bench to the Operating Room in a Translational Approach: Review and Future Endeavors in Vitreoretinal Surgery |
| title_short | Vitreous Substitutes from Bench to the Operating Room in a Translational Approach: Review and Future Endeavors in Vitreoretinal Surgery |
| title_sort | vitreous substitutes from bench to the operating room in a translational approach review and future endeavors in vitreoretinal surgery |
| topic | vitreous substitutes vitreoretinal surgery retinal detachment proliferative vitreoretinopathy silicone oil |
| url | https://www.mdpi.com/1422-0067/24/4/3342 |
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