Membrane Traffic in <i>Aspergillus oryzae</i> and Related Filamentous Fungi
The industrially important filamentous fungus <i>Aspergillus oryzae</i>, known as the yellow <i>Koji</i> mold and also designated the Japanese National fungus, has been investigated for understanding the intracellular membrane trafficking machinery due to the great ability of...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-07-01
|
| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2309-608X/7/7/534 |
| _version_ | 1797526827452858368 |
|---|---|
| author | Yujiro Higuchi |
| author_facet | Yujiro Higuchi |
| author_sort | Yujiro Higuchi |
| collection | DOAJ |
| description | The industrially important filamentous fungus <i>Aspergillus oryzae</i>, known as the yellow <i>Koji</i> mold and also designated the Japanese National fungus, has been investigated for understanding the intracellular membrane trafficking machinery due to the great ability of valuable enzyme production. The underlying molecular mechanisms of the secretory pathway delineate the main secretion route from the hyphal tip via the vesicle cluster Spitzenkörper, but also there is a growing body of evidence that septum-directed and unconventional secretion occurs in <i>A. oryzae</i> hyphal cells. Moreover, not only the secretory pathway but also the endocytic pathway is crucial for protein secretion, especially having a role in apical endocytic recycling. As a hallmark of multicellular filamentous fungal cells, endocytic organelles early endosome and vacuole are quite dynamic: the former exhibits constant long-range motility through the hyphal cells and the latter displays pleiomorphic structures in each hyphal region. These characteristics are thought to have physiological roles, such as supporting protein secretion and transporting nutrients. This review summarizes molecular and physiological mechanisms of membrane traffic, i.e., secretory and endocytic pathways, in <i>A. oryzae</i> and related filamentous fungi and describes the further potential for industrial applications. |
| first_indexed | 2024-03-10T09:35:49Z |
| format | Article |
| id | doaj.art-ecd130ddd3684247beda59bae0d3f3bb |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T09:35:49Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-ecd130ddd3684247beda59bae0d3f3bb2023-11-22T04:09:41ZengMDPI AGJournal of Fungi2309-608X2021-07-017753410.3390/jof7070534Membrane Traffic in <i>Aspergillus oryzae</i> and Related Filamentous FungiYujiro Higuchi0Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka, Fukuoka 819-0395, JapanThe industrially important filamentous fungus <i>Aspergillus oryzae</i>, known as the yellow <i>Koji</i> mold and also designated the Japanese National fungus, has been investigated for understanding the intracellular membrane trafficking machinery due to the great ability of valuable enzyme production. The underlying molecular mechanisms of the secretory pathway delineate the main secretion route from the hyphal tip via the vesicle cluster Spitzenkörper, but also there is a growing body of evidence that septum-directed and unconventional secretion occurs in <i>A. oryzae</i> hyphal cells. Moreover, not only the secretory pathway but also the endocytic pathway is crucial for protein secretion, especially having a role in apical endocytic recycling. As a hallmark of multicellular filamentous fungal cells, endocytic organelles early endosome and vacuole are quite dynamic: the former exhibits constant long-range motility through the hyphal cells and the latter displays pleiomorphic structures in each hyphal region. These characteristics are thought to have physiological roles, such as supporting protein secretion and transporting nutrients. This review summarizes molecular and physiological mechanisms of membrane traffic, i.e., secretory and endocytic pathways, in <i>A. oryzae</i> and related filamentous fungi and describes the further potential for industrial applications.https://www.mdpi.com/2309-608X/7/7/534<i>Aspergillus oryzae</i>endocytic pathwayfilamentous fungi<i>Koji</i> moldmembrane trafficsecretory pathway |
| spellingShingle | Yujiro Higuchi Membrane Traffic in <i>Aspergillus oryzae</i> and Related Filamentous Fungi Journal of Fungi <i>Aspergillus oryzae</i> endocytic pathway filamentous fungi <i>Koji</i> mold membrane traffic secretory pathway |
| title | Membrane Traffic in <i>Aspergillus oryzae</i> and Related Filamentous Fungi |
| title_full | Membrane Traffic in <i>Aspergillus oryzae</i> and Related Filamentous Fungi |
| title_fullStr | Membrane Traffic in <i>Aspergillus oryzae</i> and Related Filamentous Fungi |
| title_full_unstemmed | Membrane Traffic in <i>Aspergillus oryzae</i> and Related Filamentous Fungi |
| title_short | Membrane Traffic in <i>Aspergillus oryzae</i> and Related Filamentous Fungi |
| title_sort | membrane traffic in i aspergillus oryzae i and related filamentous fungi |
| topic | <i>Aspergillus oryzae</i> endocytic pathway filamentous fungi <i>Koji</i> mold membrane traffic secretory pathway |
| url | https://www.mdpi.com/2309-608X/7/7/534 |
| work_keys_str_mv | AT yujirohiguchi membranetrafficiniaspergillusoryzaeiandrelatedfilamentousfungi |