Post-Radiation Angiosarcoma (PRA) of the Small Bowel: Report of a Case and Review of the Literature
Angiosarcoma is a rare and aggressive neoplasia of endothelial cells which represents only 2% of all soft-tissue tumors and frequently occurs in the skin and subcutaneous tissues. It is classified in two groups: the first is represented by primary angiosarcoma, which includes cutaneous and breast an...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | Surgeries |
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| Online Access: | https://www.mdpi.com/2673-4095/4/3/38 |
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| author | Marco La Gatta Noemi Zorzetti Cinzia Baccaro Cuoghi Manuela Adele Fornelli Vincenzo Cennamo Giuseppe Giovanni Navarra |
| author_facet | Marco La Gatta Noemi Zorzetti Cinzia Baccaro Cuoghi Manuela Adele Fornelli Vincenzo Cennamo Giuseppe Giovanni Navarra |
| author_sort | Marco La Gatta |
| collection | DOAJ |
| description | Angiosarcoma is a rare and aggressive neoplasia of endothelial cells which represents only 2% of all soft-tissue tumors and frequently occurs in the skin and subcutaneous tissues. It is classified in two groups: the first is represented by primary angiosarcoma, which includes cutaneous and breast angiosarcoma; the second is constituted by secondary angiosarcoma, which is related to radiation therapy, lymphedema, exposure to some chemical toxins, and familiar syndromes. Post-radiation intestinal angiosarcoma is a special type of secondary angiosarcoma, and only a few cases have been reported in the literature. We present a case of radiation-induced small bowel angiosarcoma in an 88-year-old female patient who was admitted to our department for abdominal pain and signs of intestinal obstruction. Her clinical history included previous radiotherapy treatments after a hysterectomy for uterine fibroids, excision of the vaginal stump for squamous cell carcinoma, and the surgical removal of a left-leg cutaneous angiosarcoma. She underwent emergency surgery, and features of peritoneal carcinomatosis were detected. A histological examination showed the presence of a small intestinal angiosarcoma. At the histochemical analysis, MYC amplification was detected, suggesting that her small bowel angiosarcoma was related to past radiation treatments. |
| first_indexed | 2024-03-10T21:59:51Z |
| format | Article |
| id | doaj.art-ecd25337f6254a888cbbee01ce571060 |
| institution | Directory Open Access Journal |
| issn | 2673-4095 |
| language | English |
| last_indexed | 2024-03-10T21:59:51Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Surgeries |
| spelling | doaj.art-ecd25337f6254a888cbbee01ce5710602023-11-19T13:01:13ZengMDPI AGSurgeries2673-40952023-07-014338139010.3390/surgeries4030038Post-Radiation Angiosarcoma (PRA) of the Small Bowel: Report of a Case and Review of the LiteratureMarco La Gatta0Noemi Zorzetti1Cinzia Baccaro2Cuoghi Manuela3Adele Fornelli4Vincenzo Cennamo5Giuseppe Giovanni Navarra6Department of General Surgery, “A. Costa” Hospital—Alto Reno Terme, 40046 Bologna, ItalyDepartment of General Surgery, “A. Costa” Hospital—Alto Reno Terme, 40046 Bologna, ItalyDepartment of General Surgery, “A. Costa” Hospital—Alto Reno Terme, 40046 Bologna, ItalyDepartment of General Surgery, “A. Costa” Hospital—Alto Reno Terme, 40046 Bologna, ItalyDepartment of Pathological Anatomy, Maggiore “Carlo Alberto Pizzardi” Hospital, 40133 Bologna, ItalyDepartment of Gastroenterology, Maggiore “Carlo Alberto Pizzardi” Hospital, 40133 Bologna, ItalyDepartment of General Surgery, “A. Costa” Hospital—Alto Reno Terme, 40046 Bologna, ItalyAngiosarcoma is a rare and aggressive neoplasia of endothelial cells which represents only 2% of all soft-tissue tumors and frequently occurs in the skin and subcutaneous tissues. It is classified in two groups: the first is represented by primary angiosarcoma, which includes cutaneous and breast angiosarcoma; the second is constituted by secondary angiosarcoma, which is related to radiation therapy, lymphedema, exposure to some chemical toxins, and familiar syndromes. Post-radiation intestinal angiosarcoma is a special type of secondary angiosarcoma, and only a few cases have been reported in the literature. We present a case of radiation-induced small bowel angiosarcoma in an 88-year-old female patient who was admitted to our department for abdominal pain and signs of intestinal obstruction. Her clinical history included previous radiotherapy treatments after a hysterectomy for uterine fibroids, excision of the vaginal stump for squamous cell carcinoma, and the surgical removal of a left-leg cutaneous angiosarcoma. She underwent emergency surgery, and features of peritoneal carcinomatosis were detected. A histological examination showed the presence of a small intestinal angiosarcoma. At the histochemical analysis, MYC amplification was detected, suggesting that her small bowel angiosarcoma was related to past radiation treatments.https://www.mdpi.com/2673-4095/4/3/38primary angiosarcomasecondary angiosarcomaradiation therapysoft-tissue tumorssmall bowel obstructionpost-radiation sarcoma |
| spellingShingle | Marco La Gatta Noemi Zorzetti Cinzia Baccaro Cuoghi Manuela Adele Fornelli Vincenzo Cennamo Giuseppe Giovanni Navarra Post-Radiation Angiosarcoma (PRA) of the Small Bowel: Report of a Case and Review of the Literature Surgeries primary angiosarcoma secondary angiosarcoma radiation therapy soft-tissue tumors small bowel obstruction post-radiation sarcoma |
| title | Post-Radiation Angiosarcoma (PRA) of the Small Bowel: Report of a Case and Review of the Literature |
| title_full | Post-Radiation Angiosarcoma (PRA) of the Small Bowel: Report of a Case and Review of the Literature |
| title_fullStr | Post-Radiation Angiosarcoma (PRA) of the Small Bowel: Report of a Case and Review of the Literature |
| title_full_unstemmed | Post-Radiation Angiosarcoma (PRA) of the Small Bowel: Report of a Case and Review of the Literature |
| title_short | Post-Radiation Angiosarcoma (PRA) of the Small Bowel: Report of a Case and Review of the Literature |
| title_sort | post radiation angiosarcoma pra of the small bowel report of a case and review of the literature |
| topic | primary angiosarcoma secondary angiosarcoma radiation therapy soft-tissue tumors small bowel obstruction post-radiation sarcoma |
| url | https://www.mdpi.com/2673-4095/4/3/38 |
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