Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters
Hazem Mohamed Saleh,1 Omar A Soliman,2 Mohamed Osama Elshazly,3 Alaa Raafat,2 Adel K Gohar,2 Taher A Salaheldin41Otolaryngology Unit, Department of Medical Applications, The National Institute of Laser Enhanced Sciences, Cairo University, 2Department of Clinical Pathology, 3Department of Pathology,...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-06-01
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| Series: | International Journal of Nanomedicine |
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| Online Access: | https://www.dovepress.com/acute-hematologic-hepatologic-and-nephrologic-changes-after-intraperit-peer-reviewed-article-IJN |
| _version_ | 1819202805445951488 |
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| author | Saleh HM Soliman OA Elshazly MO Raafat A Gohar AK Salaheldin TA |
| author_facet | Saleh HM Soliman OA Elshazly MO Raafat A Gohar AK Salaheldin TA |
| author_sort | Saleh HM |
| collection | DOAJ |
| description | Hazem Mohamed Saleh,1 Omar A Soliman,2 Mohamed Osama Elshazly,3 Alaa Raafat,2 Adel K Gohar,2 Taher A Salaheldin41Otolaryngology Unit, Department of Medical Applications, The National Institute of Laser Enhanced Sciences, Cairo University, 2Department of Clinical Pathology, 3Department of Pathology, Faculty of Veterinary Medicine, Cairo University, 4Nanotechnology & Advanced Materials Central Laboratory, Agricultural Research Center, Guiza, EgyptAbstract: In vivo responses to gold nanoparticles (GNPs) vary not only according to the size, shape, surface charge, and capping agent of GNPs but also according to the animal model, the route of administration, and the exposure frequency and duration. We illustrate here the changes in some hematologic parameters, in the hepatic and renal functions, and in the histopathology of solid organs after multiple intraperitoneal injections of 18 nm GNPs in adult male Syrian golden hamsters. We scored the histopathological changes in the liver and kidneys to grade the deleterious effects. Multiple intraperitoneal injections of 18 nm GNPs in hamsters were nonlethal in the short term but resulted in macrocytosis and hypochromasia, leukocytosis, neutrophilia, lymphocytosis, and monocytosis. The hepatic and renal functions showed nonsignificant changes; however, histopathological examination showed hepatic and renal alterations ranging from mild to marked degeneration, with occasional necrosis of hepatocytes and tubular epithelium.Keywords: in vivo, hamsters, nanogold, acute |
| first_indexed | 2024-12-23T04:09:51Z |
| format | Article |
| id | doaj.art-ecd2cea195a04d06a817b7c9fab9f33a |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-23T04:09:51Z |
| publishDate | 2016-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-ecd2cea195a04d06a817b7c9fab9f33a2022-12-21T18:00:32ZengDove Medical PressInternational Journal of Nanomedicine1178-20132016-06-012016default2505251327287Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamstersSaleh HMSoliman OAElshazly MORaafat AGohar AKSalaheldin TAHazem Mohamed Saleh,1 Omar A Soliman,2 Mohamed Osama Elshazly,3 Alaa Raafat,2 Adel K Gohar,2 Taher A Salaheldin41Otolaryngology Unit, Department of Medical Applications, The National Institute of Laser Enhanced Sciences, Cairo University, 2Department of Clinical Pathology, 3Department of Pathology, Faculty of Veterinary Medicine, Cairo University, 4Nanotechnology & Advanced Materials Central Laboratory, Agricultural Research Center, Guiza, EgyptAbstract: In vivo responses to gold nanoparticles (GNPs) vary not only according to the size, shape, surface charge, and capping agent of GNPs but also according to the animal model, the route of administration, and the exposure frequency and duration. We illustrate here the changes in some hematologic parameters, in the hepatic and renal functions, and in the histopathology of solid organs after multiple intraperitoneal injections of 18 nm GNPs in adult male Syrian golden hamsters. We scored the histopathological changes in the liver and kidneys to grade the deleterious effects. Multiple intraperitoneal injections of 18 nm GNPs in hamsters were nonlethal in the short term but resulted in macrocytosis and hypochromasia, leukocytosis, neutrophilia, lymphocytosis, and monocytosis. The hepatic and renal functions showed nonsignificant changes; however, histopathological examination showed hepatic and renal alterations ranging from mild to marked degeneration, with occasional necrosis of hepatocytes and tubular epithelium.Keywords: in vivo, hamsters, nanogold, acutehttps://www.dovepress.com/acute-hematologic-hepatologic-and-nephrologic-changes-after-intraperit-peer-reviewed-article-IJNIn-vivoChangesNanogoldHamstersHistopathologyHematology |
| spellingShingle | Saleh HM Soliman OA Elshazly MO Raafat A Gohar AK Salaheldin TA Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters International Journal of Nanomedicine In-vivo Changes Nanogold Hamsters Histopathology Hematology |
| title | Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters |
| title_full | Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters |
| title_fullStr | Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters |
| title_full_unstemmed | Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters |
| title_short | Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters |
| title_sort | acute hematologic hepatologic and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters |
| topic | In-vivo Changes Nanogold Hamsters Histopathology Hematology |
| url | https://www.dovepress.com/acute-hematologic-hepatologic-and-nephrologic-changes-after-intraperit-peer-reviewed-article-IJN |
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