Cytotoxicity and Apoptotic Effect of Nisin as an Effective Bacteriocin on the Cancer Cells
Different therapeutic approaches, comprising surgery, radiotherapy, chemotherapy are used for cancer treatment. There is an extreme need for novel anti-cancer agents with minimal toxicity for normal cells that are significantly growing. Nowadays, bacteriocins or antimicrobial peptides (AMPs) are co...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Urology Research Center
2020-05-01
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| Series: | Translational Research in Urology |
| Subjects: | |
| Online Access: | https://www.transresurology.com/article_118875.html |
| _version_ | 1831562250648813568 |
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| author | Samira Karimaei Leonardo Oliveira Reis |
| author_facet | Samira Karimaei Leonardo Oliveira Reis |
| author_sort | Samira Karimaei |
| collection | DOAJ |
| description | Different therapeutic approaches, comprising surgery, radiotherapy, chemotherapy are used for cancer treatment. There is an extreme need for novel anti-cancer agents with minimal toxicity for normal cells that are significantly growing. Nowadays, bacteriocins or antimicrobial peptides (AMPs) are considered tumor cell killers. In this regard, Nisin is one of the natural AMPs produced by Lactococcus lactis. Considering that Nisin could make apoptosis through inherent pathways and cause cancer cell death, it was suggested that at appropriate doses it might be efficient and safe for cancer treatment, room for future studies. |
| first_indexed | 2024-12-17T10:35:09Z |
| format | Article |
| id | doaj.art-ecd430b6e6fe44ec9d55ff4c60f119f4 |
| institution | Directory Open Access Journal |
| issn | 2717-042X |
| language | English |
| last_indexed | 2024-12-17T10:35:09Z |
| publishDate | 2020-05-01 |
| publisher | Urology Research Center |
| record_format | Article |
| series | Translational Research in Urology |
| spelling | doaj.art-ecd430b6e6fe44ec9d55ff4c60f119f42022-12-21T21:52:25ZengUrology Research CenterTranslational Research in Urology2717-042X2020-05-0122454710.22034/TRU.2020.255094.1038Cytotoxicity and Apoptotic Effect of Nisin as an Effective Bacteriocin on the Cancer CellsSamira Karimaei 0Leonardo Oliveira Reis1Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranDepartment of Urology, UroScience, State University of Campinas, Unicamp and Pontifical Catholic University of Campinas, PUC-Campinas, Campinas, SP, BrazilDifferent therapeutic approaches, comprising surgery, radiotherapy, chemotherapy are used for cancer treatment. There is an extreme need for novel anti-cancer agents with minimal toxicity for normal cells that are significantly growing. Nowadays, bacteriocins or antimicrobial peptides (AMPs) are considered tumor cell killers. In this regard, Nisin is one of the natural AMPs produced by Lactococcus lactis. Considering that Nisin could make apoptosis through inherent pathways and cause cancer cell death, it was suggested that at appropriate doses it might be efficient and safe for cancer treatment, room for future studies.https://www.transresurology.com/article_118875.htmlcancernisincancer cellschemotherapy |
| spellingShingle | Samira Karimaei Leonardo Oliveira Reis Cytotoxicity and Apoptotic Effect of Nisin as an Effective Bacteriocin on the Cancer Cells Translational Research in Urology cancer nisin cancer cells chemotherapy |
| title | Cytotoxicity and Apoptotic Effect of Nisin as an Effective Bacteriocin on the Cancer Cells |
| title_full | Cytotoxicity and Apoptotic Effect of Nisin as an Effective Bacteriocin on the Cancer Cells |
| title_fullStr | Cytotoxicity and Apoptotic Effect of Nisin as an Effective Bacteriocin on the Cancer Cells |
| title_full_unstemmed | Cytotoxicity and Apoptotic Effect of Nisin as an Effective Bacteriocin on the Cancer Cells |
| title_short | Cytotoxicity and Apoptotic Effect of Nisin as an Effective Bacteriocin on the Cancer Cells |
| title_sort | cytotoxicity and apoptotic effect of nisin as an effective bacteriocin on the cancer cells |
| topic | cancer nisin cancer cells chemotherapy |
| url | https://www.transresurology.com/article_118875.html |
| work_keys_str_mv | AT samirakarimaei cytotoxicityandapoptoticeffectofnisinasaneffectivebacteriocinonthecancercells AT leonardooliveirareis cytotoxicityandapoptoticeffectofnisinasaneffectivebacteriocinonthecancercells |