Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is one of the diseases with a well-established gender dimorphism. The prevalence of PAH is increased in females with a ratio of 4:1, while poor survival prognosis is associated with the male gender. Nevertheless, the specific contribution of gender in disease de...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-05-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/8/5/135 |
| _version_ | 1797725913061785600 |
|---|---|
| author | Ruslan Rafikov Joel James Nolan McClain Stevan P. Tofovic Olga Rafikova |
| author_facet | Ruslan Rafikov Joel James Nolan McClain Stevan P. Tofovic Olga Rafikova |
| author_sort | Ruslan Rafikov |
| collection | DOAJ |
| description | Pulmonary arterial hypertension (PAH) is one of the diseases with a well-established gender dimorphism. The prevalence of PAH is increased in females with a ratio of 4:1, while poor survival prognosis is associated with the male gender. Nevertheless, the specific contribution of gender in disease development and progression is unclear due to the complex nature of the PAH. Oxidative and nitrosative stresses are important contributors in PAH pathogenesis; however, the role of gender in redox homeostasis has been understudied. This review is aimed to overview the possible sex-specific mechanisms responsible for the regulation of the balance between oxidants and antioxidants in relation to PAH pathobiology. |
| first_indexed | 2024-03-12T10:38:08Z |
| format | Article |
| id | doaj.art-ecd5272100bd40838c00e8acb237455e |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T10:38:08Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-ecd5272100bd40838c00e8acb237455e2023-09-02T08:32:09ZengMDPI AGAntioxidants2076-39212019-05-018513510.3390/antiox8050135antiox8050135Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial HypertensionRuslan Rafikov0Joel James1Nolan McClain2Stevan P. Tofovic3Olga Rafikova4Division of Endocrinology, University of Arizona, Tucson, AZ 85721, USADivision of Endocrinology, University of Arizona, Tucson, AZ 85721, USADivision of Endocrinology, University of Arizona, Tucson, AZ 85721, USADepartment of Pharmacology and Chemical Biology, Vascular Medicine Institute, University of Pittsburgh, Pennsylvania, PA 15260, USADivision of Endocrinology, University of Arizona, Tucson, AZ 85721, USAPulmonary arterial hypertension (PAH) is one of the diseases with a well-established gender dimorphism. The prevalence of PAH is increased in females with a ratio of 4:1, while poor survival prognosis is associated with the male gender. Nevertheless, the specific contribution of gender in disease development and progression is unclear due to the complex nature of the PAH. Oxidative and nitrosative stresses are important contributors in PAH pathogenesis; however, the role of gender in redox homeostasis has been understudied. This review is aimed to overview the possible sex-specific mechanisms responsible for the regulation of the balance between oxidants and antioxidants in relation to PAH pathobiology.https://www.mdpi.com/2076-3921/8/5/135pulmonary hypertensiongender differenceredox homeostasisoxidationantioxidants |
| spellingShingle | Ruslan Rafikov Joel James Nolan McClain Stevan P. Tofovic Olga Rafikova Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension Antioxidants pulmonary hypertension gender difference redox homeostasis oxidation antioxidants |
| title | Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension |
| title_full | Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension |
| title_fullStr | Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension |
| title_full_unstemmed | Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension |
| title_short | Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension |
| title_sort | role of gender in regulation of redox homeostasis in pulmonary arterial hypertension |
| topic | pulmonary hypertension gender difference redox homeostasis oxidation antioxidants |
| url | https://www.mdpi.com/2076-3921/8/5/135 |
| work_keys_str_mv | AT ruslanrafikov roleofgenderinregulationofredoxhomeostasisinpulmonaryarterialhypertension AT joeljames roleofgenderinregulationofredoxhomeostasisinpulmonaryarterialhypertension AT nolanmcclain roleofgenderinregulationofredoxhomeostasisinpulmonaryarterialhypertension AT stevanptofovic roleofgenderinregulationofredoxhomeostasisinpulmonaryarterialhypertension AT olgarafikova roleofgenderinregulationofredoxhomeostasisinpulmonaryarterialhypertension |