Relationship between risk factors for impaired bone health and HR-pQCT in young adults with type 1 diabetes
ObjectiveIn type 1 diabetes, risk factors associated with impaired bone health contribute to increased risk of fracture. The aim of this study was to (1): compare the high-resolution peripheral quantitative computed tomography (HR-pQCT) parameters of young adults with type 1 diabetes with those of h...
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| Format: | Article |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1144137/full |
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| author | Etienne B. Sochett Mary Dominicis Reza Vali Amer Shammas Yesmino Elia Rahim Moineddin Farid Mahmud Esther Assor Michelle Furman Steve K. Boyd Nina Lenherr-Taube |
| author_facet | Etienne B. Sochett Mary Dominicis Reza Vali Amer Shammas Yesmino Elia Rahim Moineddin Farid Mahmud Esther Assor Michelle Furman Steve K. Boyd Nina Lenherr-Taube |
| author_sort | Etienne B. Sochett |
| collection | DOAJ |
| description | ObjectiveIn type 1 diabetes, risk factors associated with impaired bone health contribute to increased risk of fracture. The aim of this study was to (1): compare the high-resolution peripheral quantitative computed tomography (HR-pQCT) parameters of young adults with type 1 diabetes with those of healthy controls (2), identify sex differences, and (3) evaluate the association between diabetes and bone health risk factors, with HR-pQCT.MethodsThis is a cross-sectional study in young Canadian adults with childhood onset type 1 diabetes. Z-scores were generated for HR-pQCT parameters using a large healthy control database. Diet, physical activity, BMI, hemoglobin A1C (A1C) and bone health measures were evaluated, and associations were analyzed using multivariate regression analysis.ResultsEighty-eight participants (age 21 ± 2.2 years; 40 males, 48 females, diabetes duration 13.9 ± 3.4 years) with type 1 diabetes were studied. Low trabecular thickness and elevated cortical geometry parameters were found suggesting impaired bone quality. There were no sex differences. Significant associations were found: Vitamin D (25(OH)D) with trabecular parameters with possible synergy with A1C, parathyroid hormone with cortical parameters, BMI with cortical bone and failure load, and diabetes duration with trabecular area.ConclusionsOur data suggests impairment of bone health as assessed by HR-pQCT in young adults with type 1 diabetes. Modifiable risk factors were associated with trabecular and cortical parameters. These findings imply that correction of vitamin D deficiency, prevention and treatment of secondary hyperparathyroidism, and optimization of metabolic control may reduce incident fractures. |
| first_indexed | 2024-04-10T06:04:26Z |
| format | Article |
| id | doaj.art-ecd618c5aef74597a068f2a2879da287 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T06:04:26Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-ecd618c5aef74597a068f2a2879da2872023-03-03T05:02:41ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-03-011410.3389/fendo.2023.11441371144137Relationship between risk factors for impaired bone health and HR-pQCT in young adults with type 1 diabetesEtienne B. Sochett0Mary Dominicis1Reza Vali2Amer Shammas3Yesmino Elia4Rahim Moineddin5Farid Mahmud6Esther Assor7Michelle Furman8Steve K. Boyd9Nina Lenherr-Taube10Department of Pediatrics, Division of Endocrinology, The Hospital for Sick Children, University of Toronto, Toronto, ON, CanadaDepartment of Pediatrics, Division of Endocrinology, The Hospital for Sick Children, University of Toronto, Toronto, ON, CanadaDepartment of Diagnostic Imaging, Division of Nuclear Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, CanadaDepartment of Diagnostic Imaging, Division of Nuclear Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, CanadaDepartment of Pediatrics, Division of Endocrinology, The Hospital for Sick Children, University of Toronto, Toronto, ON, CanadaDepartment of Family and Community Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, CanadaDepartment of Pediatrics, Division of Endocrinology, The Hospital for Sick Children, University of Toronto, Toronto, ON, CanadaDepartment of Pediatrics, Division of Endocrinology, The Hospital for Sick Children, University of Toronto, Toronto, ON, CanadaDepartment of Pediatrics, Division of Endocrinology, The Hospital for Sick Children, University of Toronto, Toronto, ON, CanadaDepartment of Radiology, McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, CanadaDivision of Endocrinology, University Children’s Hospital Zürich, Zürich, SwitzerlandObjectiveIn type 1 diabetes, risk factors associated with impaired bone health contribute to increased risk of fracture. The aim of this study was to (1): compare the high-resolution peripheral quantitative computed tomography (HR-pQCT) parameters of young adults with type 1 diabetes with those of healthy controls (2), identify sex differences, and (3) evaluate the association between diabetes and bone health risk factors, with HR-pQCT.MethodsThis is a cross-sectional study in young Canadian adults with childhood onset type 1 diabetes. Z-scores were generated for HR-pQCT parameters using a large healthy control database. Diet, physical activity, BMI, hemoglobin A1C (A1C) and bone health measures were evaluated, and associations were analyzed using multivariate regression analysis.ResultsEighty-eight participants (age 21 ± 2.2 years; 40 males, 48 females, diabetes duration 13.9 ± 3.4 years) with type 1 diabetes were studied. Low trabecular thickness and elevated cortical geometry parameters were found suggesting impaired bone quality. There were no sex differences. Significant associations were found: Vitamin D (25(OH)D) with trabecular parameters with possible synergy with A1C, parathyroid hormone with cortical parameters, BMI with cortical bone and failure load, and diabetes duration with trabecular area.ConclusionsOur data suggests impairment of bone health as assessed by HR-pQCT in young adults with type 1 diabetes. Modifiable risk factors were associated with trabecular and cortical parameters. These findings imply that correction of vitamin D deficiency, prevention and treatment of secondary hyperparathyroidism, and optimization of metabolic control may reduce incident fractures.https://www.frontiersin.org/articles/10.3389/fendo.2023.1144137/fullbone healthHR-pQCTtype 1 diabetesyoung adultsvitamin DHbA1c (A1C) |
| spellingShingle | Etienne B. Sochett Mary Dominicis Reza Vali Amer Shammas Yesmino Elia Rahim Moineddin Farid Mahmud Esther Assor Michelle Furman Steve K. Boyd Nina Lenherr-Taube Relationship between risk factors for impaired bone health and HR-pQCT in young adults with type 1 diabetes Frontiers in Endocrinology bone health HR-pQCT type 1 diabetes young adults vitamin D HbA1c (A1C) |
| title | Relationship between risk factors for impaired bone health and HR-pQCT in young adults with type 1 diabetes |
| title_full | Relationship between risk factors for impaired bone health and HR-pQCT in young adults with type 1 diabetes |
| title_fullStr | Relationship between risk factors for impaired bone health and HR-pQCT in young adults with type 1 diabetes |
| title_full_unstemmed | Relationship between risk factors for impaired bone health and HR-pQCT in young adults with type 1 diabetes |
| title_short | Relationship between risk factors for impaired bone health and HR-pQCT in young adults with type 1 diabetes |
| title_sort | relationship between risk factors for impaired bone health and hr pqct in young adults with type 1 diabetes |
| topic | bone health HR-pQCT type 1 diabetes young adults vitamin D HbA1c (A1C) |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1144137/full |
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