Expression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA mice.

Expression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA mice.

Because PML-RARA-induced acute promyelocytic leukemia (APL) is a morphologically differentiated leukemia, many groups have speculated about whether its leukemic cell of origin is a committed myeloid precursor (e.g. a promyelocyte) versus an hematopoietic stem/progenitor cell (HSPC). We originally ta...

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Bibliographic Details
Main Authors: Lukas D Wartman, John S Welch, Geoffrey L Uy, Jeffery M Klco, Tamara Lamprecht, Nobish Varghese, Rakesh Nagarajan, Timothy J Ley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3466302?pdf=render

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