Epidemiology and Comparative Analyses of the S Gene on Feline Coronavirus in Central China
Feline coronavirus (FCoV) infections present as one of two forms: a mild or symptom-less enteric infection (FEC) and a fatal systemic disease termed feline infectious peritonitis (FIP). The lack of epidemiology of FCoV in central China and the reason why different symptoms are caused by viruses of t...
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MDPI AG
2022-04-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/11/4/460 |
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| author | Hehao Ouyang Jiahao Liu Yiya Yin Shengbo Cao Rui Yan Yi Ren Dengyuan Zhou Qiuyan Li Junyi Li Xueyu Liao Wanfeng Ji Bingjie Du Youhui Si Changmin Hu |
| author_facet | Hehao Ouyang Jiahao Liu Yiya Yin Shengbo Cao Rui Yan Yi Ren Dengyuan Zhou Qiuyan Li Junyi Li Xueyu Liao Wanfeng Ji Bingjie Du Youhui Si Changmin Hu |
| author_sort | Hehao Ouyang |
| collection | DOAJ |
| description | Feline coronavirus (FCoV) infections present as one of two forms: a mild or symptom-less enteric infection (FEC) and a fatal systemic disease termed feline infectious peritonitis (FIP). The lack of epidemiology of FCoV in central China and the reason why different symptoms are caused by viruses of the same serotype have motivated this investigation. Clinical data of 81 suspected FIP cases, 116 diarrhea cases and 174 healthy cases were collected from veterinary hospitals using body cavity effusion or fecal samples. Risk factors, sequence comparison and phylogenetic studies were performed. The results indicated that FIPV was distinguished from FECV in the average hydrophobicity of amino acids among the cleavage sites of furin, as well as the mutation sites 23,531 and 23,537. FIPV included a higher minimal R-X-X-R recognition motif of furin (41.94%) than did FECV (9.1%). The serotype of FCoV was insignificantly correlated with FIP, and the clade 1 and clade 2 strains that appeared were unique to central China. Thus, it is hypothesized that this, along with the latent variables of an antigenic epitope at positions 1058 and 1060, as well as mutations at the S1/S2 sites, are important factors affecting FCoV transmission and pathogenicity. |
| first_indexed | 2024-03-09T04:20:30Z |
| format | Article |
| id | doaj.art-ecd8e28d2ef247e7bd0b3280c7621857 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T04:20:30Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-ecd8e28d2ef247e7bd0b3280c76218572023-12-03T13:49:05ZengMDPI AGPathogens2076-08172022-04-0111446010.3390/pathogens11040460Epidemiology and Comparative Analyses of the S Gene on Feline Coronavirus in Central ChinaHehao Ouyang0Jiahao Liu1Yiya Yin2Shengbo Cao3Rui Yan4Yi Ren5Dengyuan Zhou6Qiuyan Li7Junyi Li8Xueyu Liao9Wanfeng Ji10Bingjie Du11Youhui Si12Changmin Hu13State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, ChinaCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, ChinaCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, ChinaState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, ChinaCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, ChinaCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, ChinaState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, ChinaState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, ChinaCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, ChinaCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, ChinaCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, ChinaState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, ChinaState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, ChinaState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, ChinaFeline coronavirus (FCoV) infections present as one of two forms: a mild or symptom-less enteric infection (FEC) and a fatal systemic disease termed feline infectious peritonitis (FIP). The lack of epidemiology of FCoV in central China and the reason why different symptoms are caused by viruses of the same serotype have motivated this investigation. Clinical data of 81 suspected FIP cases, 116 diarrhea cases and 174 healthy cases were collected from veterinary hospitals using body cavity effusion or fecal samples. Risk factors, sequence comparison and phylogenetic studies were performed. The results indicated that FIPV was distinguished from FECV in the average hydrophobicity of amino acids among the cleavage sites of furin, as well as the mutation sites 23,531 and 23,537. FIPV included a higher minimal R-X-X-R recognition motif of furin (41.94%) than did FECV (9.1%). The serotype of FCoV was insignificantly correlated with FIP, and the clade 1 and clade 2 strains that appeared were unique to central China. Thus, it is hypothesized that this, along with the latent variables of an antigenic epitope at positions 1058 and 1060, as well as mutations at the S1/S2 sites, are important factors affecting FCoV transmission and pathogenicity.https://www.mdpi.com/2076-0817/11/4/460FCoVS genemutationseroprevalencehydrophobicity |
| spellingShingle | Hehao Ouyang Jiahao Liu Yiya Yin Shengbo Cao Rui Yan Yi Ren Dengyuan Zhou Qiuyan Li Junyi Li Xueyu Liao Wanfeng Ji Bingjie Du Youhui Si Changmin Hu Epidemiology and Comparative Analyses of the S Gene on Feline Coronavirus in Central China Pathogens FCoV S gene mutation seroprevalence hydrophobicity |
| title | Epidemiology and Comparative Analyses of the S Gene on Feline Coronavirus in Central China |
| title_full | Epidemiology and Comparative Analyses of the S Gene on Feline Coronavirus in Central China |
| title_fullStr | Epidemiology and Comparative Analyses of the S Gene on Feline Coronavirus in Central China |
| title_full_unstemmed | Epidemiology and Comparative Analyses of the S Gene on Feline Coronavirus in Central China |
| title_short | Epidemiology and Comparative Analyses of the S Gene on Feline Coronavirus in Central China |
| title_sort | epidemiology and comparative analyses of the s gene on feline coronavirus in central china |
| topic | FCoV S gene mutation seroprevalence hydrophobicity |
| url | https://www.mdpi.com/2076-0817/11/4/460 |
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