Molecular dynamics simulation study and hybrid pharmacophore model development in human LTA4H inhibitor design.

Molecular dynamics simulation study and hybrid pharmacophore model development in human LTA4H inhibitor design.

Human leukotriene A4 hydrolase (hLTA4H) is a bi-functional enzyme catalyzes the hydrolase and aminopeptidase functions upon the fatty acid and peptide substrates, respectively, utilizing the same but overlapping binding site. Particularly the hydrolase function of this enzyme catalyzes the rate-limi...

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Bibliographic Details
Main Authors:	Sundarapandian Thangapandian, Shalini John, Mahreen Arooj, Keun Woo Lee
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3320645?pdf=render

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