An update on placental drug transport and its relevance to fetal drug exposure
Pregnant women are often complicated with diseases that require treatment with medication. Most drugs administered to pregnant women are off-label without the necessary dose, efficacy, and safety information. Knowledge concerning drug transfer across the placental barrier is essential for understand...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-10-01
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| Series: | Medical Review |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/mr-2022-0025 |
| _version_ | 1797848678699892736 |
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| author | Mao Qingcheng Chen Xin |
| author_facet | Mao Qingcheng Chen Xin |
| author_sort | Mao Qingcheng |
| collection | DOAJ |
| description | Pregnant women are often complicated with diseases that require treatment with medication. Most drugs administered to pregnant women are off-label without the necessary dose, efficacy, and safety information. Knowledge concerning drug transfer across the placental barrier is essential for understanding fetal drug exposure and hence drug safety and efficacy to the fetus. Transporters expressed in the placenta, including adenosine triphosphate (ATP)-binding cassette efflux transporters and solute carrier uptake transporters, play important roles in determining drug transfer across the placental barrier, leading to fetal exposure to the drugs. In this review, we provide an update on placental drug transport, including in vitro cell/tissue, ex vivo human placenta perfusion, and in vivo animal studies that can be used to determine the expression and function of drug transporters in the placenta as well as placental drug transfer and fetal drug exposure. We also describe how the knowledge of placental drug transfer through passive diffusion or active transport can be combined with physiologically based pharmacokinetic modeling and simulation to predict systemic fetal drug exposure. Finally, we highlight knowledge gaps in studying placental drug transport and predicting fetal drug exposure and discuss future research directions to fill these gaps. |
| first_indexed | 2024-04-09T18:32:28Z |
| format | Article |
| id | doaj.art-ecdf6a6f921244f4bdec2039cd63c5b0 |
| institution | Directory Open Access Journal |
| issn | 2749-9642 |
| language | English |
| last_indexed | 2024-04-09T18:32:28Z |
| publishDate | 2022-10-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Medical Review |
| spelling | doaj.art-ecdf6a6f921244f4bdec2039cd63c5b02023-04-11T17:07:17ZengDe GruyterMedical Review2749-96422022-10-012550151110.1515/mr-2022-0025An update on placental drug transport and its relevance to fetal drug exposureMao Qingcheng0Chen Xin1Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USADepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USAPregnant women are often complicated with diseases that require treatment with medication. Most drugs administered to pregnant women are off-label without the necessary dose, efficacy, and safety information. Knowledge concerning drug transfer across the placental barrier is essential for understanding fetal drug exposure and hence drug safety and efficacy to the fetus. Transporters expressed in the placenta, including adenosine triphosphate (ATP)-binding cassette efflux transporters and solute carrier uptake transporters, play important roles in determining drug transfer across the placental barrier, leading to fetal exposure to the drugs. In this review, we provide an update on placental drug transport, including in vitro cell/tissue, ex vivo human placenta perfusion, and in vivo animal studies that can be used to determine the expression and function of drug transporters in the placenta as well as placental drug transfer and fetal drug exposure. We also describe how the knowledge of placental drug transfer through passive diffusion or active transport can be combined with physiologically based pharmacokinetic modeling and simulation to predict systemic fetal drug exposure. Finally, we highlight knowledge gaps in studying placental drug transport and predicting fetal drug exposure and discuss future research directions to fill these gaps.https://doi.org/10.1515/mr-2022-0025adenosine triphosphate-binding cassette transportersfetal drug exposurephysiologically based pharmacokinetic modeling and simulationplacental drug transportsolute carrier transporters |
| spellingShingle | Mao Qingcheng Chen Xin An update on placental drug transport and its relevance to fetal drug exposure Medical Review adenosine triphosphate-binding cassette transporters fetal drug exposure physiologically based pharmacokinetic modeling and simulation placental drug transport solute carrier transporters |
| title | An update on placental drug transport and its relevance to fetal drug exposure |
| title_full | An update on placental drug transport and its relevance to fetal drug exposure |
| title_fullStr | An update on placental drug transport and its relevance to fetal drug exposure |
| title_full_unstemmed | An update on placental drug transport and its relevance to fetal drug exposure |
| title_short | An update on placental drug transport and its relevance to fetal drug exposure |
| title_sort | update on placental drug transport and its relevance to fetal drug exposure |
| topic | adenosine triphosphate-binding cassette transporters fetal drug exposure physiologically based pharmacokinetic modeling and simulation placental drug transport solute carrier transporters |
| url | https://doi.org/10.1515/mr-2022-0025 |
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