The role and mechanism of inflammatory response to growing rod implantation in early onset scoliosis
Growing rod implantation, a surgery treatment for EOS (early onset scoliosis), may cause a kind of chronic inflammation called metalosis and all other implant-related complications because of the metal debris released by the implants as a result of fraction and corrosion. There is no complete explan...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1282573/full |
| _version_ | 1827783146309943296 |
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| author | Haoran Zhang Bingtai Han Zhiyi Li Yiwei Zhao You Du Yang Yang Shengru Wang Jianguo Zhang |
| author_facet | Haoran Zhang Bingtai Han Zhiyi Li Yiwei Zhao You Du Yang Yang Shengru Wang Jianguo Zhang |
| author_sort | Haoran Zhang |
| collection | DOAJ |
| description | Growing rod implantation, a surgery treatment for EOS (early onset scoliosis), may cause a kind of chronic inflammation called metalosis and all other implant-related complications because of the metal debris released by the implants as a result of fraction and corrosion. There is no complete explanation of immunologic mechanisms of metalosis up to now. This review demonstrates the researches on metalosis from the clinical issues down to basic immunologic mechanisms. Adverse reactions of metal implants are mainly the formation of NLRP3 (nod-like receptor protein 3) inflammasome, primed by TLR4 (toll-like receptor protein 4), activated by phagocytosis and often accompanied by type Ⅳ hypersensitive reaction. Recent studies found that TNF-α (tumor necrosis factor α) also participates in priming, and activation of inflammasome requires disturbance of lysosome and release of cathepsin B. Ca-074Me and MCC950 are therapeutic interventions worth exploring in aseptic loosening of orthopedic implants. |
| first_indexed | 2024-03-11T15:42:41Z |
| format | Article |
| id | doaj.art-ece0e59eb74c422399ff1f191837b62c |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-11T15:42:41Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-ece0e59eb74c422399ff1f191837b62c2023-10-26T12:02:35ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-10-011110.3389/fcell.2023.12825731282573The role and mechanism of inflammatory response to growing rod implantation in early onset scoliosisHaoran ZhangBingtai HanZhiyi LiYiwei ZhaoYou DuYang YangShengru WangJianguo ZhangGrowing rod implantation, a surgery treatment for EOS (early onset scoliosis), may cause a kind of chronic inflammation called metalosis and all other implant-related complications because of the metal debris released by the implants as a result of fraction and corrosion. There is no complete explanation of immunologic mechanisms of metalosis up to now. This review demonstrates the researches on metalosis from the clinical issues down to basic immunologic mechanisms. Adverse reactions of metal implants are mainly the formation of NLRP3 (nod-like receptor protein 3) inflammasome, primed by TLR4 (toll-like receptor protein 4), activated by phagocytosis and often accompanied by type Ⅳ hypersensitive reaction. Recent studies found that TNF-α (tumor necrosis factor α) also participates in priming, and activation of inflammasome requires disturbance of lysosome and release of cathepsin B. Ca-074Me and MCC950 are therapeutic interventions worth exploring in aseptic loosening of orthopedic implants.https://www.frontiersin.org/articles/10.3389/fcell.2023.1282573/fullgrowing rodearly onset scoliosismetalosisinflammatory responseNLRP3 inflammasome |
| spellingShingle | Haoran Zhang Bingtai Han Zhiyi Li Yiwei Zhao You Du Yang Yang Shengru Wang Jianguo Zhang The role and mechanism of inflammatory response to growing rod implantation in early onset scoliosis Frontiers in Cell and Developmental Biology growing rod early onset scoliosis metalosis inflammatory response NLRP3 inflammasome |
| title | The role and mechanism of inflammatory response to growing rod implantation in early onset scoliosis |
| title_full | The role and mechanism of inflammatory response to growing rod implantation in early onset scoliosis |
| title_fullStr | The role and mechanism of inflammatory response to growing rod implantation in early onset scoliosis |
| title_full_unstemmed | The role and mechanism of inflammatory response to growing rod implantation in early onset scoliosis |
| title_short | The role and mechanism of inflammatory response to growing rod implantation in early onset scoliosis |
| title_sort | role and mechanism of inflammatory response to growing rod implantation in early onset scoliosis |
| topic | growing rod early onset scoliosis metalosis inflammatory response NLRP3 inflammasome |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1282573/full |
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