LncRNA FENDRR Suppresses Melanoma Growth via Influencing c-Myc mRNA Level
Changying Niu,1 Shenxing Tan2 1Dermatological Department, Affiliated Hospital of Weifang Medical University, Weifang, People’s Republic of China; 2Plastic Surgery, Affiliated Hospital of Weifang Medical University, Weifang, People’s Republic of ChinaCorrespondence: Shenxing Tan, Tel +86 18754411279,...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-08-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/lncrna-fendrr-suppresses-melanoma-growth-via-influencing-c-myc-mrna-le-peer-reviewed-fulltext-article-CCID |
| _version_ | 1797745437778640896 |
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| author | Niu C Tan S |
| author_facet | Niu C Tan S |
| author_sort | Niu C |
| collection | DOAJ |
| description | Changying Niu,1 Shenxing Tan2 1Dermatological Department, Affiliated Hospital of Weifang Medical University, Weifang, People’s Republic of China; 2Plastic Surgery, Affiliated Hospital of Weifang Medical University, Weifang, People’s Republic of ChinaCorrespondence: Shenxing Tan, Tel +86 18754411279, Email tsx105@163.comBackground: Long non-coding RNAs (lncRNAs) play an important role in the occurrence of melanoma. However, the specific molecular mechanisms that regulate its biological function are still poorly understood. Therefore, the main purpose of this study is to elucidate the internal mechanism of lncRNA-FENDRR as a biological marker for the occurrence of SKCM and its influence on its proliferation.Results: FENDRR is low expressed in skin cutaneous melanoma (SKCM) tissues and appears to be at an even lower level as the tumor progresses. However, the high expression of FENDRR can affect the proliferation of SKCM cell line A375. The results of flow cytometry showed that after overexpression of FENDRR, the cell cycle was arrested in the G1/G0 phase. Bioinformatics analysis and RIP results showed that FENDRR could be combined with YTHDF1. Together, these complexes regulate c-Myc mRNA level and determine cell proliferation.Conclusion: We found that overexpression of FENDRR can effectively inhibit SKCM, which provides a new theoretical basis for new therapeutic approaches and targeted RNA drugs.Keywords: long non-coding RNAs, FENDRR, melanoma, cell proliferation |
| first_indexed | 2024-03-12T15:24:14Z |
| format | Article |
| id | doaj.art-ece3d687fa974569885558f3e6081ffb |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-03-12T15:24:14Z |
| publishDate | 2023-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-ece3d687fa974569885558f3e6081ffb2023-08-10T19:04:44ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152023-08-01Volume 162119212885779LncRNA FENDRR Suppresses Melanoma Growth via Influencing c-Myc mRNA LevelNiu CTan SChangying Niu,1 Shenxing Tan2 1Dermatological Department, Affiliated Hospital of Weifang Medical University, Weifang, People’s Republic of China; 2Plastic Surgery, Affiliated Hospital of Weifang Medical University, Weifang, People’s Republic of ChinaCorrespondence: Shenxing Tan, Tel +86 18754411279, Email tsx105@163.comBackground: Long non-coding RNAs (lncRNAs) play an important role in the occurrence of melanoma. However, the specific molecular mechanisms that regulate its biological function are still poorly understood. Therefore, the main purpose of this study is to elucidate the internal mechanism of lncRNA-FENDRR as a biological marker for the occurrence of SKCM and its influence on its proliferation.Results: FENDRR is low expressed in skin cutaneous melanoma (SKCM) tissues and appears to be at an even lower level as the tumor progresses. However, the high expression of FENDRR can affect the proliferation of SKCM cell line A375. The results of flow cytometry showed that after overexpression of FENDRR, the cell cycle was arrested in the G1/G0 phase. Bioinformatics analysis and RIP results showed that FENDRR could be combined with YTHDF1. Together, these complexes regulate c-Myc mRNA level and determine cell proliferation.Conclusion: We found that overexpression of FENDRR can effectively inhibit SKCM, which provides a new theoretical basis for new therapeutic approaches and targeted RNA drugs.Keywords: long non-coding RNAs, FENDRR, melanoma, cell proliferationhttps://www.dovepress.com/lncrna-fendrr-suppresses-melanoma-growth-via-influencing-c-myc-mrna-le-peer-reviewed-fulltext-article-CCIDlong non-coding rnasfendrrmelanomacell proliferation |
| spellingShingle | Niu C Tan S LncRNA FENDRR Suppresses Melanoma Growth via Influencing c-Myc mRNA Level Clinical, Cosmetic and Investigational Dermatology long non-coding rnas fendrr melanoma cell proliferation |
| title | LncRNA FENDRR Suppresses Melanoma Growth via Influencing c-Myc mRNA Level |
| title_full | LncRNA FENDRR Suppresses Melanoma Growth via Influencing c-Myc mRNA Level |
| title_fullStr | LncRNA FENDRR Suppresses Melanoma Growth via Influencing c-Myc mRNA Level |
| title_full_unstemmed | LncRNA FENDRR Suppresses Melanoma Growth via Influencing c-Myc mRNA Level |
| title_short | LncRNA FENDRR Suppresses Melanoma Growth via Influencing c-Myc mRNA Level |
| title_sort | lncrna fendrr suppresses melanoma growth via influencing c myc mrna level |
| topic | long non-coding rnas fendrr melanoma cell proliferation |
| url | https://www.dovepress.com/lncrna-fendrr-suppresses-melanoma-growth-via-influencing-c-myc-mrna-le-peer-reviewed-fulltext-article-CCID |
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