Event-Related Potential Measures of the Passive Processing of Rapidly and Slowly Presented Auditory Stimuli in MCI
Much research effort is currently devoted to the development of a simple, low-cost method to determine early signs of Alzheimer’s disease (AD) pathology. The present study employs a simple paradigm in which event-related potentials (ERPs) were recorded to a single auditory stimulus that was presente...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.659618/full |
| _version_ | 1819169344924418048 |
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| author | Farooq Kamal Farooq Kamal Cassandra Morrison Cassandra Morrison Kenneth Campbell Vanessa Taler Vanessa Taler |
| author_facet | Farooq Kamal Farooq Kamal Cassandra Morrison Cassandra Morrison Kenneth Campbell Vanessa Taler Vanessa Taler |
| author_sort | Farooq Kamal |
| collection | DOAJ |
| description | Much research effort is currently devoted to the development of a simple, low-cost method to determine early signs of Alzheimer’s disease (AD) pathology. The present study employs a simple paradigm in which event-related potentials (ERPs) were recorded to a single auditory stimulus that was presented rapidly or very slowly while the participant was engaged in a visual task. A multi-channel EEG was recorded in 20 healthy older adults and 20 people with mild cognitive impairment (MCI). In two different conditions, a single 80 dB sound pressure level (SPL) auditory stimulus was presented every 1.5 s (fast condition) or every 12.0 s (slow condition). Participants were instructed to watch a silent video and ignore the auditory stimuli. Auditory processing thus occurred passively. When the auditory stimuli were presented rapidly (every 1.5 s), N1 and P2 amplitudes did not differ between the two groups. When the stimuli were presented very slowly, the amplitude of N1 and P2 increased in both groups and their latencies were prolonged. The amplitude of N1 did not significantly differ between the two groups. However, the subsequent positivity was reduced in people with MCI compared to healthy older adults. This late positivity in the slow condition may reflect a delayed P2 or a summation of a composite P2 + P3a. In people with MCI, the priority of processing may not be switched from the visual task to the potentially much more relevant auditory input. ERPs offer promise as a means to identify the pathology underlying cognitive impairment associated with MCI. |
| first_indexed | 2024-12-22T19:18:01Z |
| format | Article |
| id | doaj.art-ece3ff8174e44d009f3751e5fc974e32 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-22T19:18:01Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-ece3ff8174e44d009f3751e5fc974e322022-12-21T18:15:28ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-04-011310.3389/fnagi.2021.659618659618Event-Related Potential Measures of the Passive Processing of Rapidly and Slowly Presented Auditory Stimuli in MCIFarooq Kamal0Farooq Kamal1Cassandra Morrison2Cassandra Morrison3Kenneth Campbell4Vanessa Taler5Vanessa Taler6School of Psychology, University of Ottawa, Ontario, ON, CanadaBruyère Research Institute, Ottawa, ON, CanadaSchool of Psychology, University of Ottawa, Ontario, ON, CanadaBruyère Research Institute, Ottawa, ON, CanadaSchool of Psychology, University of Ottawa, Ontario, ON, CanadaSchool of Psychology, University of Ottawa, Ontario, ON, CanadaBruyère Research Institute, Ottawa, ON, CanadaMuch research effort is currently devoted to the development of a simple, low-cost method to determine early signs of Alzheimer’s disease (AD) pathology. The present study employs a simple paradigm in which event-related potentials (ERPs) were recorded to a single auditory stimulus that was presented rapidly or very slowly while the participant was engaged in a visual task. A multi-channel EEG was recorded in 20 healthy older adults and 20 people with mild cognitive impairment (MCI). In two different conditions, a single 80 dB sound pressure level (SPL) auditory stimulus was presented every 1.5 s (fast condition) or every 12.0 s (slow condition). Participants were instructed to watch a silent video and ignore the auditory stimuli. Auditory processing thus occurred passively. When the auditory stimuli were presented rapidly (every 1.5 s), N1 and P2 amplitudes did not differ between the two groups. When the stimuli were presented very slowly, the amplitude of N1 and P2 increased in both groups and their latencies were prolonged. The amplitude of N1 did not significantly differ between the two groups. However, the subsequent positivity was reduced in people with MCI compared to healthy older adults. This late positivity in the slow condition may reflect a delayed P2 or a summation of a composite P2 + P3a. In people with MCI, the priority of processing may not be switched from the visual task to the potentially much more relevant auditory input. ERPs offer promise as a means to identify the pathology underlying cognitive impairment associated with MCI.https://www.frontiersin.org/articles/10.3389/fnagi.2021.659618/fullmild cognitive impairmentMCIevent-related potentialsERPsbiomarker |
| spellingShingle | Farooq Kamal Farooq Kamal Cassandra Morrison Cassandra Morrison Kenneth Campbell Vanessa Taler Vanessa Taler Event-Related Potential Measures of the Passive Processing of Rapidly and Slowly Presented Auditory Stimuli in MCI Frontiers in Aging Neuroscience mild cognitive impairment MCI event-related potentials ERPs biomarker |
| title | Event-Related Potential Measures of the Passive Processing of Rapidly and Slowly Presented Auditory Stimuli in MCI |
| title_full | Event-Related Potential Measures of the Passive Processing of Rapidly and Slowly Presented Auditory Stimuli in MCI |
| title_fullStr | Event-Related Potential Measures of the Passive Processing of Rapidly and Slowly Presented Auditory Stimuli in MCI |
| title_full_unstemmed | Event-Related Potential Measures of the Passive Processing of Rapidly and Slowly Presented Auditory Stimuli in MCI |
| title_short | Event-Related Potential Measures of the Passive Processing of Rapidly and Slowly Presented Auditory Stimuli in MCI |
| title_sort | event related potential measures of the passive processing of rapidly and slowly presented auditory stimuli in mci |
| topic | mild cognitive impairment MCI event-related potentials ERPs biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.659618/full |
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