Early treatment failure during treatment of <it>Plasmodium falciparum</it> malaria with atovaquone-proguanil in the Republic of Ivory Coast
<p>Abstract</p> <p>The increased spread of drug-resistant malaria highlights the need for alternative drugs for treatment and chemoprophylaxis. The combination of atovaquone‐proguanil (Malarone®) has shown high efficacy against <it>Plasmodium falciparum</it> with only m...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-05-01
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| Series: | Malaria Journal |
| Subjects: | |
| Online Access: | http://www.malariajournal.com/content/11/1/146 |
| _version_ | 1811298699403329536 |
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| author | Wurtz Nathalie Pascual Aurélie Marin-Jauffre Adeline Bouchiba Housem Benoit Nicolas Desbordes Marc Martelloni Maryse de Santi Vincent Richa Georges Taudon Nicolas Pradines Bruno Briolant Sébastien |
| author_facet | Wurtz Nathalie Pascual Aurélie Marin-Jauffre Adeline Bouchiba Housem Benoit Nicolas Desbordes Marc Martelloni Maryse de Santi Vincent Richa Georges Taudon Nicolas Pradines Bruno Briolant Sébastien |
| author_sort | Wurtz Nathalie |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The increased spread of drug-resistant malaria highlights the need for alternative drugs for treatment and chemoprophylaxis. The combination of atovaquone‐proguanil (Malarone®) has shown high efficacy against <it>Plasmodium falciparum</it> with only mild side-effects. Treatment failures have been attributed to suboptimal dosages or to parasite resistance resulting from a point mutation in the <it>cytochrome b</it> gene. In this paper, a case of early treatment failure was reported in a patient treated with atovaquone-proguanil; this failure was not associated with a mutation in the parasite <it>cytochrome b</it> gene, with impaired drug bioavailability, or with re-infection.</p> |
| first_indexed | 2024-04-13T06:24:06Z |
| format | Article |
| id | doaj.art-ece5613526434581b5998913a8cc0ba2 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-04-13T06:24:06Z |
| publishDate | 2012-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-ece5613526434581b5998913a8cc0ba22022-12-22T02:58:31ZengBMCMalaria Journal1475-28752012-05-0111114610.1186/1475-2875-11-146Early treatment failure during treatment of <it>Plasmodium falciparum</it> malaria with atovaquone-proguanil in the Republic of Ivory CoastWurtz NathaliePascual AurélieMarin-Jauffre AdelineBouchiba HousemBenoit NicolasDesbordes MarcMartelloni Marysede Santi VincentRicha GeorgesTaudon NicolasPradines BrunoBriolant Sébastien<p>Abstract</p> <p>The increased spread of drug-resistant malaria highlights the need for alternative drugs for treatment and chemoprophylaxis. The combination of atovaquone‐proguanil (Malarone®) has shown high efficacy against <it>Plasmodium falciparum</it> with only mild side-effects. Treatment failures have been attributed to suboptimal dosages or to parasite resistance resulting from a point mutation in the <it>cytochrome b</it> gene. In this paper, a case of early treatment failure was reported in a patient treated with atovaquone-proguanil; this failure was not associated with a mutation in the parasite <it>cytochrome b</it> gene, with impaired drug bioavailability, or with re-infection.</p>http://www.malariajournal.com/content/11/1/146MalariaPlasmodium falciparumMalarone®Atovaquone-proguanilCytochrome bResistanceClinical failurein vitroAnti-malarial drug |
| spellingShingle | Wurtz Nathalie Pascual Aurélie Marin-Jauffre Adeline Bouchiba Housem Benoit Nicolas Desbordes Marc Martelloni Maryse de Santi Vincent Richa Georges Taudon Nicolas Pradines Bruno Briolant Sébastien Early treatment failure during treatment of <it>Plasmodium falciparum</it> malaria with atovaquone-proguanil in the Republic of Ivory Coast Malaria Journal Malaria Plasmodium falciparum Malarone® Atovaquone-proguanil Cytochrome b Resistance Clinical failure in vitro Anti-malarial drug |
| title | Early treatment failure during treatment of <it>Plasmodium falciparum</it> malaria with atovaquone-proguanil in the Republic of Ivory Coast |
| title_full | Early treatment failure during treatment of <it>Plasmodium falciparum</it> malaria with atovaquone-proguanil in the Republic of Ivory Coast |
| title_fullStr | Early treatment failure during treatment of <it>Plasmodium falciparum</it> malaria with atovaquone-proguanil in the Republic of Ivory Coast |
| title_full_unstemmed | Early treatment failure during treatment of <it>Plasmodium falciparum</it> malaria with atovaquone-proguanil in the Republic of Ivory Coast |
| title_short | Early treatment failure during treatment of <it>Plasmodium falciparum</it> malaria with atovaquone-proguanil in the Republic of Ivory Coast |
| title_sort | early treatment failure during treatment of it plasmodium falciparum it malaria with atovaquone proguanil in the republic of ivory coast |
| topic | Malaria Plasmodium falciparum Malarone® Atovaquone-proguanil Cytochrome b Resistance Clinical failure in vitro Anti-malarial drug |
| url | http://www.malariajournal.com/content/11/1/146 |
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