Monitoring the Circulation and Impact of SARS-Cov-2 Variants on Public Health During COVID-19 Pandemic: a Case Study in a South Brazil Population
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was the responsible for the coronavirus disease 2019 (COVID-19) pandemic. Because of its high transmissibility, allied to the emergence of some variants of concern (VOC), like Alpha, Beta, Gamma, Delta, and Omicron, the detection...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Instituto de Tecnologia do Paraná (Tecpar)
2023-05-01
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| Series: | Brazilian Archives of Biology and Technology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132023000100317&lng=en&tlng=en |
| _version_ | 1827942504932048896 |
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| author | Larissa Glugoski Laís Priscila Karas Viviane Nogaroto Fernanda Couto Miléo Ana Luiza Augustinho Mackelly Simionatto Marcos Pileggi Bruno Ribeiro Cruz Giovani Marino Fávero Marcelo Ricardo Vicari |
| author_facet | Larissa Glugoski Laís Priscila Karas Viviane Nogaroto Fernanda Couto Miléo Ana Luiza Augustinho Mackelly Simionatto Marcos Pileggi Bruno Ribeiro Cruz Giovani Marino Fávero Marcelo Ricardo Vicari |
| author_sort | Larissa Glugoski |
| collection | DOAJ |
| description | Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was the responsible for the coronavirus disease 2019 (COVID-19) pandemic. Because of its high transmissibility, allied to the emergence of some variants of concern (VOC), like Alpha, Beta, Gamma, Delta, and Omicron, the detection of these strains must be rapid and efficient. Among the tests available, the reverse-transcriptase polymerase-chain reaction (RT-PCR) is considered the gold standard test for COVID-19 detection, and the use of specific primers and probes can discriminate the different COVID-19 variants. In this study, we screened 317 individuals tested positive for COVID-19 from the municipality of Ponta Grossa (Paraná State, Brazil), from April/2021 to February/2022, aiming to identify the Gamma, Delta, and Omicron variants, by RT-PCR, using specific probes. The Gamma variant was detected from April/2021 to September/2021. The Delta variant was subsequently detected from August/2021 to November/2021. The Omicron variant was the unique strain detected from December/2021 to February/2022 and, because of its high rate of transmissibility, it caused a considerable increase in the number of COVID-19 infections. Mass testing is considered an important strategy for COVID-19 control and, the correct detection of new strains, could improve the knowledge about the virus´ behavior, permitting the development of drugs and optimized vaccines. |
| first_indexed | 2024-03-13T10:00:17Z |
| format | Article |
| id | doaj.art-ece877a301394a60b0e307326ad283ff |
| institution | Directory Open Access Journal |
| issn | 1678-4324 |
| language | English |
| last_indexed | 2024-03-13T10:00:17Z |
| publishDate | 2023-05-01 |
| publisher | Instituto de Tecnologia do Paraná (Tecpar) |
| record_format | Article |
| series | Brazilian Archives of Biology and Technology |
| spelling | doaj.art-ece877a301394a60b0e307326ad283ff2023-05-23T07:34:32ZengInstituto de Tecnologia do Paraná (Tecpar)Brazilian Archives of Biology and Technology1678-43242023-05-016610.1590/1678-4324-2023220591Monitoring the Circulation and Impact of SARS-Cov-2 Variants on Public Health During COVID-19 Pandemic: a Case Study in a South Brazil PopulationLarissa Glugoskihttps://orcid.org/0000-0003-1631-0647Laís Priscila Karashttps://orcid.org/0000-0002-5585-7242Viviane Nogarotohttps://orcid.org/0000-0001-5757-9648Fernanda Couto Miléohttps://orcid.org/0000-0002-0194-3014Ana Luiza Augustinhohttps://orcid.org/0000-0002-3678-8309Mackelly Simionattohttps://orcid.org/0000-0002-5445-8696Marcos Pileggihttps://orcid.org/0000-0003-1633-8295Bruno Ribeiro Cruzhttps://orcid.org/0000-0001-6940-0262Giovani Marino Fáverohttps://orcid.org/0000-0002-1946-3262Marcelo Ricardo Vicarihttps://orcid.org/0000-0003-3913-9889Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was the responsible for the coronavirus disease 2019 (COVID-19) pandemic. Because of its high transmissibility, allied to the emergence of some variants of concern (VOC), like Alpha, Beta, Gamma, Delta, and Omicron, the detection of these strains must be rapid and efficient. Among the tests available, the reverse-transcriptase polymerase-chain reaction (RT-PCR) is considered the gold standard test for COVID-19 detection, and the use of specific primers and probes can discriminate the different COVID-19 variants. In this study, we screened 317 individuals tested positive for COVID-19 from the municipality of Ponta Grossa (Paraná State, Brazil), from April/2021 to February/2022, aiming to identify the Gamma, Delta, and Omicron variants, by RT-PCR, using specific probes. The Gamma variant was detected from April/2021 to September/2021. The Delta variant was subsequently detected from August/2021 to November/2021. The Omicron variant was the unique strain detected from December/2021 to February/2022 and, because of its high rate of transmissibility, it caused a considerable increase in the number of COVID-19 infections. Mass testing is considered an important strategy for COVID-19 control and, the correct detection of new strains, could improve the knowledge about the virus´ behavior, permitting the development of drugs and optimized vaccines.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132023000100317&lng=en&tlng=enCoronavirusDeltaGammaOmicronRT-PCRvaccination |
| spellingShingle | Larissa Glugoski Laís Priscila Karas Viviane Nogaroto Fernanda Couto Miléo Ana Luiza Augustinho Mackelly Simionatto Marcos Pileggi Bruno Ribeiro Cruz Giovani Marino Fávero Marcelo Ricardo Vicari Monitoring the Circulation and Impact of SARS-Cov-2 Variants on Public Health During COVID-19 Pandemic: a Case Study in a South Brazil Population Brazilian Archives of Biology and Technology Coronavirus Delta Gamma Omicron RT-PCR vaccination |
| title | Monitoring the Circulation and Impact of SARS-Cov-2 Variants on Public Health During COVID-19 Pandemic: a Case Study in a South Brazil Population |
| title_full | Monitoring the Circulation and Impact of SARS-Cov-2 Variants on Public Health During COVID-19 Pandemic: a Case Study in a South Brazil Population |
| title_fullStr | Monitoring the Circulation and Impact of SARS-Cov-2 Variants on Public Health During COVID-19 Pandemic: a Case Study in a South Brazil Population |
| title_full_unstemmed | Monitoring the Circulation and Impact of SARS-Cov-2 Variants on Public Health During COVID-19 Pandemic: a Case Study in a South Brazil Population |
| title_short | Monitoring the Circulation and Impact of SARS-Cov-2 Variants on Public Health During COVID-19 Pandemic: a Case Study in a South Brazil Population |
| title_sort | monitoring the circulation and impact of sars cov 2 variants on public health during covid 19 pandemic a case study in a south brazil population |
| topic | Coronavirus Delta Gamma Omicron RT-PCR vaccination |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132023000100317&lng=en&tlng=en |
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